Feverfew (Tanacetum parthenium L.): Tissue culture and parthenolide synthesis

Plant Science

Volumn 116, Issue 2, 1996, Pages 223-232

  Brown, Andrew M G ^a   Lowe, Kenneth C ^a   Davey, Michael R ^a   Brian Power, J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Feverfew; Organogenesis; Parthenolide; Secondary metabolism; Tanacetwn parthenium; Tissue culture

Indexed keywords

EID: 0008645758     PISSN: 01689452     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-9452(96)04396-8     Document Type: Article

References (7)

1. W.A. Groenewegen, D.W. Knight and S. Heptinstall, Progress in the medicinal chemistry of the herb, feverfew, in: G.P. Ellis and D.K. Luscombe (Eds.), Progress in Medicinal Chemistry, Vol. 29, Elsevier Science Publishers, Amsterdam, 1992, pp. 217-238.
2. E.S. Johnson, N.P. Kadam, D.M. Hylands and P.J. Hylands, Efficacy of feverfew as prophylactic treatment of migraine. Br. Med. J., 291 (1985) 569-573.
3. J.J. Murphy, S. Heptinstall and J.R.A. Mitchell, Randomised double-blind, placebo-controlled trial of feverfew in migraine prevention. Lancet II (1988) 189-192.
4. W.A. Groenewegen, D.W. Knight and S. Heptinstall, Compounds extracted from feverfew that have antisecretory activity contain an α-methylene butyrotactone unit. J. Pharm. Pharmacol., 38 (1986) 709-712.
5. S. Heptinstall, W.A. Groenewegen, P. Spangenberg and W. Loesche, Extracts of feverfew may inhibit platelet behaviour via neutralisation of sulphydryl groups. J. Pharm. Pharmacol., 39 (1987) 459-465.
6. R.W.J. Barsby, U. Salan, D.W. Knight and J.R.S. Hoult, Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta. J. Pharm. Pharmacol., 44 (1992) 737-740.
7. A.J.B. Hay, M. Hamburger, K. Hostettmann and J.R.S. Hoult, Toxic inhibition of smooth muscle contractility by plant-derived sesquiterpenes caused by their chemically reactive α-methylenebutyrolactone functions. Br. J. Pharmacol., 112 (1994) 9-12.