메뉴 건너뛰기




Volumn 13, Issue 2, 1997, Pages 156-165

Thermodynamics of metabolic pathways for penicillin production: Analysis of thermodynamic feasibility and free energy changes during fed-batch cultivation

Author keywords

[No Author keywords available]

Indexed keywords


EID: 0008056562     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp970010c     Document Type: Article
Times cited : (21)

References (40)
  • 1
    • 0024655483 scopus 로고
    • Lysine biosynthesis in Penicillium chrysogenum is regulated by feedback inhibition of α-aminoadipate reductase
    • Affenzeller, K.; Jaklitsh, W. M.; Honlinger, C.; Kubicek, C. P. Lysine biosynthesis in Penicillium chrysogenum is regulated by feedback inhibition of α-aminoadipate reductase. FEMS Microbiol. Lett. 1989, 58, 293-298.
    • (1989) FEMS Microbiol. Lett. , vol.58 , pp. 293-298
    • Affenzeller, K.1    Jaklitsh, W.M.2    Honlinger, C.3    Kubicek, C.P.4
  • 2
    • 0027301365 scopus 로고
    • The isopenicillin N acyltransferase of Penicillium chrysogenum has isopenicillin N amidohydrolase, 6-aminopenicillanic acid acyltransferase and penicillin amidase activities, all of which are encoded by the single penDE gene
    • Alvarez, E.; Meesschaert, B.; Montenegro, E.; Gutiérres, S.; Diéz, B.; Barredo, J. L.; Martín, J. F. The isopenicillin N acyltransferase of Penicillium chrysogenum has isopenicillin N amidohydrolase, 6-aminopenicillanic acid acyltransferase and penicillin amidase activities, all of which are encoded by the single penDE gene. Eur. J. Biochem. 1993, 323-332.
    • (1993) Eur. J. Biochem. , pp. 323-332
    • Alvarez, E.1    Meesschaert, B.2    Montenegro, E.3    Gutiérres, S.4    Diéz, B.5    Barredo, J.L.6    Martín, J.F.7
  • 3
    • 0025895183 scopus 로고
    • Towards a science of metabolic engineering
    • Bailey, J. E. Towards a science of metabolic engineering. Science 1991, 252, 1668-1674.
    • (1991) Science , vol.252 , pp. 1668-1674
    • Bailey, J.E.1
  • 6
    • 0028500687 scopus 로고
    • Metabolic control of glycolysis and branching to ethanol production in chemostat cultures of Sacharomyces cerevisiae under carbon, nitrogen or phosphate limitations
    • Cortassa, S.; Aon, M. A. Metabolic control of glycolysis and branching to ethanol production in chemostat cultures of Sacharomyces cerevisiae under carbon, nitrogen or phosphate limitations. Enzyme Microb. Technol. 1994, 16, 761-770.
    • (1994) Enzyme Microb. Technol. , vol.16 , pp. 761-770
    • Cortassa, S.1    Aon, M.A.2
  • 8
    • 0026802334 scopus 로고
    • Metabolic Control Analysis: A survey of its theoretical and experimental development
    • Fell, D. Metabolic Control Analysis: A survey of its theoretical and experimental development. Biochem. J. 1992, 286, 313-330.
    • (1992) Biochem. J. , vol.286 , pp. 313-330
    • Fell, D.1
  • 9
    • 0018188651 scopus 로고
    • Uptake and metabolism of α-aminoadipic acid by Penicillium chrysogenum WIS 54-1255
    • Friedrich, C. J.; Demain, A. L. Uptake and metabolism of α-aminoadipic acid by Penicillium chrysogenum WIS 54-1255. Arch. Microbiol. 1978, 119, 43-47.
    • (1978) Arch. Microbiol. , vol.119 , pp. 43-47
    • Friedrich, C.J.1    Demain, A.L.2
  • 10
    • 0018819381 scopus 로고
    • Pyridine nucleotide levels and ratios in Aspergillus niger
    • Führer, L. C.; Kubiceck, C. P.; Röhr, M. Pyridine nucleotide levels and ratios in Aspergillus niger. Can. J. Microbiol. 1980, 26, 405-408.
    • (1980) Can. J. Microbiol. , vol.26 , pp. 405-408
    • Führer, L.C.1    Kubiceck, C.P.2    Röhr, M.3
  • 11
    • 0025400371 scopus 로고
    • Fermentation pathway kinetics and metabolic flux control in suspended and immobilised Sacharomyces cerevisiae
    • Gallazo, J.; Bailey, J. E. fermentation pathway kinetics and metabolic flux control in suspended and immobilised Sacharomyces cerevisiae. Enzyme Microb. Technol. 1990, 12, 162-172.
    • (1990) Enzyme Microb. Technol. , vol.12 , pp. 162-172
    • Gallazo, J.1    Bailey, J.E.2
  • 12
    • 0015989446 scopus 로고
    • A linear steady state treatment of enzymatic chains. General properties, control and effector strength
    • Heinrich, R.; Rapoport, T. A linear steady state treatment of enzymatic chains. General properties, control and effector strength. Eur. J. Biochem. 1974, 42, 89-95.
    • (1974) Eur. J. Biochem. , vol.42 , pp. 89-95
    • Heinrich, R.1    Rapoport, T.2
  • 13
    • 0022985811 scopus 로고
    • The central metabolic pathways of Escherichia coli: Relationship between flux and control of a branch point, efficiency of conversion to biomass and excretion of acetate
    • Holms, W. H. The central metabolic pathways of Escherichia coli: Relationship between flux and control of a branch point, efficiency of conversion to biomass and excretion of acetate. Cur. Top. Cell. Reg. 1986, 28, 69-105
    • (1986) Cur. Top. Cell. Reg. , vol.28 , pp. 69-105
    • Holms, W.H.1
  • 14
    • 0025370788 scopus 로고
    • Homocitrate synthase from Penicillium chrysogenum
    • Jaklitsh, W. M.; Kubicek, C. P. Homocitrate synthase from Penicillium chrysogenum. Biochem. J. 1990, 269, 247-253.
    • (1990) Biochem. J. , vol.269 , pp. 247-253
    • Jaklitsh, W.M.1    Kubicek, C.P.2
  • 15
    • 0022467397 scopus 로고
    • α-aminoadipate pool concentration and penicillin biosynthesis in strains of Penicillium chrysogenum
    • Jaklitsh, W. M.; Hampel, W.; Rohr, M.; Kubicek, C. P. α-aminoadipate pool concentration and penicillin biosynthesis in strains of Penicillium chrysogenum. Can. J. Microbiol. 1986, 32, 473-480.
    • (1986) Can. J. Microbiol. , vol.32 , pp. 473-480
    • Jaklitsh, W.M.1    Hampel, W.2    Rohr, M.3    Kubicek, C.P.4
  • 17
    • 0029278153 scopus 로고
    • Metabolic flux distributions in Penicillium chrysogenum during fed-batch cultivations
    • Jørgensen, H. S.; Nielsen, J.; Villadsen, J. Metabolic flux distributions in Penicillium chrysogenum during fed-batch cultivations. Biotechnol. Bioeng. 1995a, 46, 117-131.
    • (1995) Biotechnol. Bioeng. , vol.46 , pp. 117-131
    • Jørgensen, H.S.1    Nielsen, J.2    Villadsen, J.3
  • 18
    • 0028904797 scopus 로고
    • Analysis of penicillin V biosynthesis during fed-batch cultivations with a high yielding strain of Penicillium chrysogenum
    • Jørgensen, H. S.; Nielsen, J.; Villadsen, J.; Møllgaard, H. Analysis of penicillin V biosynthesis during fed-batch cultivations with a high yielding strain of Penicillium chrysogenum. Appl. Microbiol. Biotechnol. 1995b, 43, 123-130.
    • (1995) Appl. Microbiol. Biotechnol. , vol.43 , pp. 123-130
    • Jørgensen, H.S.1    Nielsen, J.2    Villadsen, J.3    Møllgaard, H.4
  • 19
    • 0015824267 scopus 로고
    • The control of flux
    • Kacser, H.; Burns, J. A. The control of flux. SEB Symposia 1973, XXVIII, 65-144.
    • (1973) SEB Symposia , vol.28 , pp. 65-144
    • Kacser, H.1    Burns, J.A.2
  • 20
    • 0027518445 scopus 로고
    • Subcellular compartmentation of Penicillium chrysogenum. The amino acid precursors are derived from the vacuole
    • Lendenfeld, T.; Ghali, D.; Wolschek, M.; Kubicek-Prantz, E. M.; Kubicek, C. P. Subcellular compartmentation of Penicillium chrysogenum. The amino acid precursors are derived from the vacuole. J. Biol. Chem. 1993, 268, 665-671.
    • (1993) J. Biol. Chem. , vol.268 , pp. 665-671
    • Lendenfeld, T.1    Ghali, D.2    Wolschek, M.3    Kubicek-Prantz, E.M.4    Kubicek, C.P.5
  • 21
    • 0027601708 scopus 로고
    • Advances in Metabolic Control Analysis
    • Liao, J. C.; Delgado, J. Advances in Metabolic Control Analysis. Biotechnol. Prog. 1993, 9, 221-233.
    • (1993) Biotechnol. Prog. , vol.9 , pp. 221-233
    • Liao, J.C.1    Delgado, J.2
  • 22
    • 0026673332 scopus 로고
    • Regulation of α-aminoadipate reductase from Penicillium chrysogenum in relation to the flux from α-aminoadipate into penicillin biosynthesis
    • Lu, Y.; Mach, R. L.; Affenzeller, K.; Kubiceck, C. P. Regulation of α-aminoadipate reductase from Penicillium chrysogenum in relation to the flux from α-aminoadipate into penicillin biosynthesis. Can. J. Microbiol. 1992, 38, 758-763.
    • (1992) Can. J. Microbiol. , vol.38 , pp. 758-763
    • Lu, Y.1    Mach, R.L.2    Affenzeller, K.3    Kubiceck, C.P.4
  • 23
    • 0019119615 scopus 로고
    • Inhibition and repression of homocitrate synthase by lysine in Penicillium chrysogenum
    • Luengo, J. M.; Revilla, G.; López-Nieto, M. J.; Villanueva, J. R.; Martín, J. F. Inhibition and repression of homocitrate synthase by lysine in Penicillium chrysogenum. J. Bacteriol. 1980, 144, 869-876.
    • (1980) J. Bacteriol. , vol.144 , pp. 869-876
    • Luengo, J.M.1    Revilla, G.2    López-Nieto, M.J.3    Villanueva, J.R.4    Martín, J.F.5
  • 25
    • 0025701406 scopus 로고
    • Group contributions for estimating standard Gibbs energies of formation of biochemical compounds in aqueous solutions
    • Mavrovouniotis, M. L. Group contributions for estimating standard Gibbs energies of formation of biochemical compounds in aqueous solutions. Biotechnol. Bioeng. 1990, 36, 1070-1082.
    • (1990) Biotechnol. Bioeng. , vol.36 , pp. 1070-1082
    • Mavrovouniotis, M.L.1
  • 26
    • 0026353854 scopus 로고
    • Estimation of standard Gibbs energy changes of biotransformations
    • Mavrovouniotis, M. L. Estimation of standard Gibbs energy changes of biotransformations. J. Biol. Chem. 1991, 266, 1440-1445.
    • (1991) J. Biol. Chem. , vol.266 , pp. 1440-1445
    • Mavrovouniotis, M.L.1
  • 28
    • 0029294006 scopus 로고
    • Metabolic Control Analysis of the penicilin biosynthetic pathway in a high-yielding strain of Penicillium chrysogenum
    • Nielsen, J.; Jørgensen, H. S. Metabolic Control Analysis of the penicilin biosynthetic pathway in a high-yielding strain of Penicillium chrysogenum. Biotechnol. Prog. 1995, 11, 299-305.
    • (1995) Biotechnol. Prog. , vol.11 , pp. 299-305
    • Nielsen, J.1    Jørgensen, H.S.2
  • 30
    • 0021383728 scopus 로고
    • Equations and calculations for fermentations of butyric acid bacteria
    • Papoutsakis, E. T. Equations and calculations for fermentations of butyric acid bacteria. Biotechnol. Bioeng. 1984, 26, 174-187.
    • (1984) Biotechnol. Bioeng. , vol.26 , pp. 174-187
    • Papoutsakis, E.T.1
  • 32
    • 15844370671 scopus 로고    scopus 로고
    • Pathway kinetics and metabolic control analysis of a high-yielding strain of Penicillium chrysogenum during fed-batch cultivations
    • Pissarra, P. N.; Nielsen, J.; Bazin, M. J. Pathway kinetics and metabolic control analysis of a high-yielding strain of Penicillium chrysogenum during fed-batch cultivations. Biotechnol. Bioeng. 1996, 51, 168-176.
    • (1996) Biotechnol. Bioeng. , vol.51 , pp. 168-176
    • Pissarra, P.N.1    Nielsen, J.2    Bazin, M.J.3
  • 33
    • 0022971322 scopus 로고
    • Glucose represses formation of δ-(L-α-Aminoadipyl)-L-Cysteinyl-D-Valine and Isopenicillin N Synthetase but not Penicillin Acyltransferase in Penicillium chrysogenum
    • Revilla, G.; Ramos, F. R.; López-Nieto, M. J.; Alvarez, E.; Martín, J. F. Glucose represses formation of δ-(L-α-Aminoadipyl)-L-Cysteinyl-D-Valine and Isopenicillin N Synthetase but not Penicillin Acyltransferase in Penicillium chrysogenum. J. Bacteriol. 1986, 168, 947-952.
    • (1986) J. Bacteriol. , vol.168 , pp. 947-952
    • Revilla, G.1    Ramos, F.R.2    López-Nieto, M.J.3    Alvarez, E.4    Martín, J.F.5
  • 35
    • 0017343370 scopus 로고
    • Energy conservation in chemotrophic anaerobic bacteria
    • Thauer, R. K.; Jungerman, K.; Decker, K. Energy conservation in chemotrophic anaerobic bacteria. Bacteriol. Rev. 1977, 41, 100-180.
    • (1977) Bacteriol. Rev. , vol.41 , pp. 100-180
    • Thauer, R.K.1    Jungerman, K.2    Decker, K.3
  • 36
    • 0028765255 scopus 로고
    • Modelling approach to control of carbohydrate metabolism during Citric acid accumulation by Aspergillus niger:I model definition and stability of the steady state
    • Torres, N. Modelling approach to control of carbohydrate metabolism during Citric acid accumulation by Aspergillus niger:I model definition and stability of the steady state. Biotechnol. Bioeng. 1994, 44, 104-111.
    • (1994) Biotechnol. Bioeng. , vol.44 , pp. 104-111
    • Torres, N.1
  • 37
    • 0027572102 scopus 로고
    • Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction
    • Vallino, J. J.; Stephanopoulos, G. Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction. Biotechnol. Bioeng. 1993, 41, 633-646.
    • (1993) Biotechnol. Bioeng. , vol.41 , pp. 633-646
    • Vallino, J.J.1    Stephanopoulos, G.2
  • 39
    • 0026559943 scopus 로고
    • Biochemical studies on the activity of the δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase activity from Streptomyces clavuligerus
    • Zhang, J.; Wolfe, S.; Demain, A. L. Biochemical studies on the activity of the δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase activity from Streptomyces clavuligerus. Biochem. J. 1992, 283, 691-698.
    • (1992) Biochem. J. , vol.283 , pp. 691-698
    • Zhang, J.1    Wolfe, S.2    Demain, A.L.3
  • 40
    • 0004122938 scopus 로고
    • Macmillan Publishing Co.: New York
    • Zubay, G. Biochemistry; Macmillan Publishing Co.: New York, 1988.
    • (1988) Biochemistry
    • Zubay, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.