Inhibition of wound closure by transforming growth factor-β and dexamethasone in a fetal mouse limb organ culture model

Wound Repair and Regeneration

Volumn 4, Issue 4, 1996, Pages 482-488

  Ehrlich, H Paul ^a   Blewett, Christopher ^a   Krummel, Thomas M ^a   Cutroneo, Kenneth R ^b  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0008022404     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-475x.1996.40413.x     Document Type: Article

References (27)

1. Somasundram K, Prathap K. Intra-uterine healing of skin wounds in rabbit foetuses. J Pathol 1970;10:81-6.
2. Bleacher JC, Adolph VR, Dillon PW, Krummel TM. Isolated fetal mouse limbs: gestation effects on tissue repair in an unperfused system. J Ped Surg 1993;28:1312-5.
3. Sandberg N. Time relationship between administration of cortisone and wound healing in rats. Acta Chir Scand 1964;127:446-51.
4. Ehrlich HP, Hunt TK. Effects of cortisone and vitamin A on wound healing. Ann Surg 1966;167:324-8.
5. Ehrlich HP, Hunt TK. The effects of cortisone and anabolic steroids on the tensile strength of healing wounds. Ann Surg 1969;170:203-6.
6. Kelley SF, Felix AM, Ehrlich HP. The antagonism of glucocorticoid inhibition of wound healing in rats by growth hormone releasing factor. Proc Soc Exp Biol Med 1990;194:320-6.
7. Pierce GF, Mustoe TA, Lingelbach J, Masakowski VR, Gramates P, Deuel TF. TGFβ reverses the glucocorticoid-induced wound-healing deficit in rats: Possible regulation in macrophages by platelet-derived growth factor. Proc Natl Acad Sci USA 1989;86:2229-33.
8. Newman RA, Cutroneo KR. Glucocorticoids selectively decrease the synthesis of hydroxylated collagen peptides. Mol Pharmacol 1978;14:185-98.
9. Cockayne D, Sterling KM Jr, Shull S, Mintz KP, Illeyne S, Cutroneo KR. Glucocorticoids decrease the synthesis of type I procollagen mRNAs. Biochemistry 1986;25:3202-9.
10. Rokowski RJ, Sheehy J, Cutroneo KR. Glucocorticoid-mediated selective reduction of functioning collagen messenger ribonucleic acid. Arch Biochem Biophys 1981;210:74-81.
11. Oikarinen J, Pihlajaniemi T, Hamalainen L, Kivirikko KI. Cortisol decreases the cellular concentration of translatable procollagen mRNA species in cultured human skin fibroblasts. Biochem Biophys Acta 1983;741:297-302.
12. Sterling KM Jr, Harris MJ, Mitchell JJ, Cutroneo KR. Bleomycin treatment of chick fibroblasts causes an increase of polysomal type I procollagen mRNAs. J Biol Chem 1983;14438-44.
13. Sterling KM Jr, Harris MJ, Mitchell JJ, DePetrillo TA, Delaney G, Cutroneo, KR. Dexamethasone decreases the amounts of type I procollagen mRNAs in vivo and in fibroblast cell cultures. J Biol Chem 1983;258:7644-7.
14. Hamalainen L, Oikarinen J, Kivirikko KI. Synthesis and degradation of type I procollagen mRNAs in cultured human skin fibroblasts and the effect of cortisol. J Biol Chem 1985;260:720-5.
15. Raghow R, Gossage D, Kang AH. Pretranslational regulation of type I collagen, fibronectin and a 50-kilodalton noncollagenous extracellular protein by dexamethasone in rat fibroblasts. J Biol Chem 1986;261:4677-84.
16. Walsh MJ, Leleiko NS, Sterling KM Jr. Regulation of types I, III, and IV procollagen mRNA synthesis in glucocorticoid-mediated intestinal development. J Biol Chem 1987;262:10814-8.
17. Weiner FR, Czaja MJ, Jefferson DM, Giambrone MA, Tur-Kaspa R, Reid LM, Zern MA. The effects of dexamethasone on in vitro collagen gene expression. J Biol Chem 1987;262:6955-8.
18. Sporn MB, Roberts AB, Shull JH, Smith JM, Ward JM. Polypeptide transforming growth factor isolated from bovine sources and used for wound healing in vivo. Science 1983;219:1329-30.
19. Whitby DJ, Ferguson MWJ. Immunohistochemical localization of growth factors in fetal wound healing. Dev Biol 1991;147:207-15.
20. Houghton PE, Keffer KA, Krummel KM. The role of transforming growth factor-β in the conversion from scarless healing to healing with scar formation. Wound Rep Reg 1995;3:229-36.
21. Edwards DR, Murphy G, Reynolds JJ, Whitham SE, Docherty AJP, Angel P, Heath JK. TGFβ modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J 1987;6:1899-904.
22. Shipley GD, Pittelkow MR, Willie JJ, Scott RE, Moses HL. Reversible inhibition of normal human prokeratinocyte proliferation by type β transforming growth factor-growth inhibitor in serum-free medium. Canc Res 1986;46:2068-71.
23. Constantine VS, Mowry RW. The selective staining of human dermal collagen: The use of picrosirius red F3BA with polarization microscopically. J Invest Derm 1968;50:419-23.
24. Perez JR, Shull S, Gendimenico GJ, Capetola RJ, Mezick JA, Cutroneo KR. Glucocorticoid and retinoid regulation of alpha-2 type I procollagen promoter activity. J Cell Biochem 1992;50:26-34.
25. Krummel TM, Michna BA, Thomas BL, Sporn MB, Nelson JM, Salzberg AM, Cohen IK, Diegelmann RF. Transforming growth factor beta induces fibrosis in a fetal wound model. J Ped Surg 1988;23:647-52.
26. Border WA, Ruoslahti E. Transforming growth factor-β in disease: the dark side of tissue repair. J Clin Invest 1992;90:1-7.
27. McMullen H, Longaker MT, Cabrera RC, Sung J, Canete J, Siebert JW, Lorenz HP, Gold LI. Spatial and temporal expression of transforming growth factor-β isoforms during ovine excisional and incisional wound repair. Wound Rep Reg 1994;3:141-56.