Chiral RP-HPLC assay for propafenone enantiomers in rat liver microsomal incubates and its application in vitro metabolism

Yaoxue Xuebao

Volumn 35, Issue 5, 2000, Pages 370-373

  Zhou, Quan ^a   Yao, Tong Wei ^b   Zeng, Su ^b  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

2,3,4,6 Tetra O acetyl glucopyranosyl isothiocyanate; Propafenone; RP HPLC; Stereoselectivity

Indexed keywords

EID: 0007731169     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

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2. Kroemer HK, Funck-Brentano C, Silberstein DJ, et al. Stereoselective disposition and pharmacologic activity of propafenone enantiomers [J]. Circulation, 1989,79: 1068.
3. Kroemer HK, Fischer C, Meese CO, et al. Enantiomer/enantiomer interaction of S- and R-propafenone for cytochrome P450 II D 6-catalyzed 5-hydroxylation: in vitro evaluation of the mechanism [J]. Mol Pharmacol, 1990,40:135.
4. Bohm R, Ellrich R, Koytcher R. Quantification of R- and S-propafenone and of the main metabolite in plasma [J]. Pharmazie, 1995,8:542.
5. Kern R. Internal standard simultaneous assay of propafenone and 5-hydroxypropafenone enantiomers in human plasma by means of HPLC [J] . Methods Find Exp Clin Pharmacol, 1994,3:203.