Genetic control of purine biosynthesis in yeast pichia methanolica: Identification of bifunctional gene ADE7,4 controlling activity of GAR and AIR synthetases

Genetika

Volumn 34, Issue 1, 1998, Pages 52-60

  Dutova, T A ^a  

^a STATE RESEARCH INSTITUTE OF GENETICS AND SELECTION OF INDUSTRIAL MICROORGANISMS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0007388342     PISSN: 00166758     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Costellu W.P., Bevan E.A. Complementation between ad 5/7 alleles in yeast // Genetics. 1964. V. 50. JNs 6. P. 1219-1230.
2. Dorfman B. Allelic complementation at the ad 5/7 locus in yeast // Genetics. 1964. V. 50. Ks 6. P. 1231-1243.
3. Friis J., Flury F., Leupold U. Characterization of spontaneous mutants of mitotic and meiotic origin in the adel locus of Schizosaccharomyces pombe II Mutât. Res. 1971. V. 11. P. 373-390.
4. Fluri R., Coddington A., Flury U. The product of the adel gene in Schizosaccharomyces pombe: A bifunctional enzyme catalysing two distinct steps in purine biosynthesis // Molec. and Gen. Genet. 1976. V. 147. K° 2. P. 271-282.
5. ItoH., Fukuda Y., Murata K., Kimura A. Transformation of intact yeast cells treated with alkali cations // J. Bacteriol. 1988. V. 153. P. 163-168.
6. Maniatis T., Fritsch E.F., Sambrook J. Molecular Cloning: A Laboratory Manual. N.Y.: Cold Spring Harbor Lab. Press, 1982.
7. Flaks J.G., Lekens L.N. The enzymes of purine nucleotide synthesis de novo II Methods in Enzymology / Eds Colowick S.P., Kaplan N.O. N.Y.: Acad. Press, 1963. V. 6. P. 76-79.
8. Bradford M A. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding // Anal. Biochem. 1976. V. 72. JV° 2. P. 248-254.
9. Schrimsher J.L., Schendel E.J., Stable J. Isolation of a multifunctional protein with aminoimidazole ribonucleotide synthetase, glycinamide ribonucleotide synthetase, and glycinamide ribonucleotide transformylase activities. Characterization of aminoimidazole ribonucleotide synthetase // Biochemistry. 1986. V. 25. P. 4356-4365.
10. Tolstorukov I., Dutova T. Spontaneous mutagenesis in red adenine mutants of Pichia methanolica II Yeast Genetics and Molecular Biology Meeting. Madison, 1996. P. 196B.
11. HenikoffS. The Saccharomyces cerevisiae ADE 5,7 protein is homologous to overlapping Drosophila melano-gaster Gart polypeptides // J. Mol. Biol. 1986. V. 190. P. 519-528.
12. Southern E.M. Detection specific sequences among DNA fragments separated by gel electrophoresis // J. Mol. Biol. 1975. V. 98. P. 503-517.
13. Tolstorukov 1.1., Tarutina M.G. Mechanisms of transformation of the methylotrophic yeast Pichia methanolica (P. pinus) MH4 with theLEU2 gene of the yeast Saccharomyces cerevisiae Yeast. 1992. V. 8. (Special issue: The 16th Intern. Conf. on Yeast Genetics and Molecular Biology.).
14. McKenzieR.,SchuchertP.,KilbeyB. Sequence of the bifunctional adel gene in the purine biosynthesis pathway//Curr. Genet. 1987. V. 12. .N° 8. P. 591-597.
15. Lachtchev K., Semenova V., Beburov M., Tolstorukov I. Genetics in the type strain of the methylotrophic yeast Pichia angusta (= H. polymorpha) NRRL y-5445 (= CBS 4732) // Regulation of metabolism and biotechnology: Abstracts of the 15th Internat. Specialized Symp. on yeasts. Riga, 1991. P. 82.
16. Masters M. E. coli map location of purine genes on the physical map of Escherichia coli II J. Bacteriol. 1990. V. 172. Xs 3. P. 1173.
17. Zalkin H., Ebbole D.J. Organization and regulation or genes encoding biosynthetic enzymes in Bacillus subtilis Hi. Biol. Chem. 1988. V. 263. -Na 4. P. 1595-1598.
18. SchrimsherJ.L., Schendel E.J., Stuhle J., Smith J.M. Purification and characterization of aminoimidazole ribonucleotide synthetase from Escherichia coli II Biochemistry. 1986. V. 25. P. 4366-4371.
19. Henikoff S. Multifunctional polypeptides for purine de novo synthesis//BioEssays. 1987. V. 6. X° 1. P. 8-13.
20. Zalkin H., Dixon J.E. De novo purine nucleotide biosynthesis // Progress in Nucleic Acid Research and Molecular Biology. 1992. V. 42. P. 259-287.