A facile synthesis of 1,2,4-oxadiazolidin-3-ones via tandem O, N-addition of hydroxyureas to methyl propiolate

Synlett

Volumn , Issue 11, 1998, Pages 1217-1218

  Zong, Kyukwan ^a   Shin, Seung Il ^a   Kim, Hyoung Rae ^a   Ryu, Eung K ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0007003048     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1998-1936     Document Type: Article

References (7)

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2. Reck, R.; Jochims, J. C. Chem. Ber. 1982, 115, 860-870.
3. Agocs, P.; Gajdacsi, A.; Pinter, Z.; Nagy, S.; Fabian, I.; 1976, Ger. Offen. 2,625,848 (Cl. C07D271/06).
4. Becker, R.; Rohr, W. Liebigs Ann. Chem. 1981, 2, 191-197.
5. Zong, K.; Shin, S. I.; Ryu, E. K., Tetrahedron Lett. 1998, 39, 6227.
6. Lantos, I.; Flisak, J.; Liu, L.; Matsuoka, R.; Mendelson, W.; Stevenson, D.; Tuman, K.; Tucker, L.; Zhang, W.-Y.; Adams, J.; Sorenson, M.; Garigipati, R.; Erhardt, K.; Ross, S. J. Org. Chem. 1997, 62, 5385-5391.
7. General procedure for the preparation of 3a-3h; To a solution of hyroxyurea (1.0 equiv.) and methyl propiolate (1.05 equiv.) in acetonitrile was added 4-methyl morpholine (0.2 equiv.) at room temperature.