Characterization of recombinant cytokine fragments using isotachophoresis-capillary zone electrophoresis, reversed-phase high performance liquid chromatography, and mass spectrometry

Pharmaceutical Research

Volumn 16, Issue 5, 1999, Pages 695-701

  Gysler, J ^a   Helk, B ^b   Dambacher, S ^b   Tjaden, U R ^a   Van Der Greef, J ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Capillary zone electrophoresis; Degradation; High performance liquid chromatography; Isotachophoresis; Mass spectrometry; Proteins

Indexed keywords

RECOMBINANT CYTOKINE; RECOMBINANT INTERLEUKIN 3; RECOMBINANT INTERLEUKIN 6;

ARTICLE; CAPILLARY ZONE ELECTROPHORESIS; DRUG QUALITY; DRUG SCREENING; ISOTACHOPHORESIS; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; QUALITY CONTROL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME C GROUP; ELECTROPHORESIS, CAPILLARY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; INTERLEUKIN-6; MURAMIDASE; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; SEQUENCE ANALYSIS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0006949149     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018824608288     Document Type: Article

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