Senescence-accelerated mouse (SAM): With special reference to development and pathobiological phenotypes

ILAR Journal

Volumn 38, Issue 3, 1997, Pages 109-118

  Takeda, Toshio ^a   Higuchi, Keiichi ^a   Hosokawa, Masanori ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0006799389     PISSN: 10842020     EISSN: None     Source Type: Journal    
DOI: 10.1093/ilar.38.3.109     Document Type: Article

References (122)

1. Abe Y, Yuasa M, Kajiwara Y, Hosono M. 1994. Defects of immune cells in the senescence-accelerated mouse: A model for learning and memory deficits in the aged. Cell Immunol 157:59-69.
2. Akiguchi I, Yagi H, Ueno M, Takemura M, Kitabayashi T, Seriu T, Kawamata T, Takeda T. 1994. Age-related morphological changes in the brains of senescence-accelerated mouse (SAMP8). In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 67-72.
3. Akiyama H, Kameyama M, Akiguchi I, Sugiyama H, Kawamata T, Fukuyama H, Kimura H, Matsushita M, Takeda T. 1986. Periodic acid-Schiff (PAS)-positive, granular structures increase in the brain of senescence accelerated mouse (SAM). Acta Neuropathol 72:124-129.
4. Amano T, Nakanishi H, Oka M, Yamamoto K. 1995. Increased expression of cathepsins E and D in reactive microglial cells associated with spongiform degeneration in the brain stem of senescence-accelerated mouse. Exp Neurol 136:171-182.
5. Ashida Y, Takeda T, Hosokawa M. 1994. Protein alterations in age-related cataract associated with a persistent hyaloid vascular system in senescence-accelerated mouse (SAM). Exp Eye Res 59:467-474.
6. Chen WH, Hosokawa M, Tsuboyama T, Ono T, Iizuka T, Takeda T. 1989. Age-related changes in the temporomandibular joint of the senescence accelerated mouse (SAM) SAM-P/3 as a new murine model of degenerative joint disease. Am J Pathol 135:379-385.
7. Chen WH, Hosokawa M, Wang J, Iizuka T, Takeda T. 1994. Senescence-accelerated mouse, SAMP3, as a murine model of degenerative joint disease. In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 227-230.
8. Choi JH, Kim JI, Kim DW, Moon YS, Kim IS, Chung HY. 1994. Age-related physiological changes in brain membranes of senescence-accelerated mouse (SAM). In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 321-324.
9. Cotran RS, Kumar V, Robbins SL. 1989. Diseases of aging. In: Robbins Pathologic Basis of Disease. Philadelphia: W.B. Saunders Company, p 543-551.
10. Ebbesen P. 1974. Mutually exclusive occurrence of amyloidosis and thymic leukemia in casein treated AKR mice. Br J Cancer 29:76-79.
11. Edamatsu R, Mori A, Packer L. 1995. The spin-trap N-tert-a-phenyl-butylnitrone prolongs the life span of the senescence accelerated mouse. Biochem Biophys Res Commun 211:847-849.
12. Festing MFW. 1992. Origins and characteristics of inbred strains of mice, 14th listing. Mouse Genome 90:236-237.
13. Festing MFW. 1993. Origins and characteristics of inbred strains of mice. Mouse Genome 91:471-472.
14. Finch CE. 1994. Genetic influence on lifespan, mortality rates, and age-related disease. In: Longevity, Senescence, and the Genome. Chicago: The University of Chicago Press. p 298-356.
15. Flood JF, Farr SA, Kaiser FE, Morley JE. 1995. Age-related impairment in learning but not memory in SAMP8 female mice. Pharmacol Biochem Behav 50:661-664.
16. Flood JF, Harris FJ, Morley JE. 1996. Age-related changes in hippocampal drug facilitation of memory processing in SAMP8 mice. Neurobiol Aging 17:15-24.
17. Flood JF, Morley JE. 1992. Early onset of age-related impairment of aversive and appetitive learning in the SAM-P/8 mouse. J Gerontol 47:B52-B59.
18. Flood JF, Morley JE. 1993. Age-related changes in foot shock avoidance acquisition and retention in senescence accelerated mouse (SAM). Neurobiol Aging 14:153-157.
19. Flood JF, Morley JE, LaRegina M. 1993. Age-related changes in the pharmacological improvement of retention in senescence accelerated mouse (SAM). Neurobiol Aging 14:159-166.
20. Fujibayashi Y, Waki A, Wada K, Ueno M, Magata Y, Yonekura Y, Konishi J, Takeda T, Yokoyama A. 1994. Differential aging pattern of cerebral accumulation of radiolabeled glucose and amino acid in the senescence accelerated mouse (SAM), a new model for the study of memory impairment. Biol Pharm Bull 17:102-105.
21. Hanada K, Hosono M, Hosokawa T, Chen WH, Tsuboyama T, Takeda T. 1989. Immune responses in newly developed short-lived SAM mice III. Genetic control of defective helper T-cell activity in in vitro primary antibody response. Immunology 68:540-546.
22. Hanada K, Katoh H, Hosokawa T, Hosono M, Takeda T. 1991. Immune responses in newly developed short-lived SAM mice IV. Chromosomal location of a gene controlling defective helper T-cell activity. Immunology 74:160-164.
23. Hanada K, Katoh H, Toichi E, Hosokawa T, Naiki H, Hosokawa M, Takeda T, Hosono M. 1994. Genetic control of defective helper T cell activity in in vitro antibody responses in short-lived SAM mice. In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 171-174.
24. Haruna H, Inaba M, Inaba K, Taketani S, Sugimura K, Fukuba Y, Doi H, Toki J, Tokunaga R, Ikehara S. 1995. Abnormalities of B cells and dendritic cells in SAMP1 mice. Eur J Immunol 25:1319-1325.
25. Higuchi K, Matsumura A, Hashimoto K, Honma A, Takeshita S, Hosokawa M, Yasuhira K, Takeda T. 1983a. Isolation and characterization of senile amyloid-related antigenic substance (SASSAM) from mouse serum ApoSASSAM is a low molecular weight apoprotein of high density lipoprotein. J Exp Med 158:1600-1614.
26. Higuchi K, Matsumura A, Honma A, Takeshita S, Hashimoto K, Yasuhira K, Takeda T. 1983b. Systemic senile amyloid in senescence-accelerated mice: A unique fibril protein demostrated in tissues from various organs by the unlabeled immunoperoxidase method. Lab Invest 48:231-240.
27. Higuchi K, Kitagawa K, Naiki H, Hanada K, Hosokawa M, Takeda T. 1991a. Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice. Relationship between the molecular type of apoA-II and mouse senile amyloidosis. Biochem J 279:427-433.
28. Higuchi K, Naiki H, Kitagawa K, Hosokawa M, Takeda T. 1991b. Mouse senile amyloidosis ASSAM amyloidosis in mice presents universally as a systemic age-associated amyloidosis. Virchows Arch B Cell Pathol 60:231-239.
29. Higuchi K, Yonezu T, Kogishi K, Matsumura A, Takeshita S, Higuchi K, Kohno A, Matsushita M, Hosokawa M, Takeda T. 1986. Purification and characterization of a senile amyloid-related antigenic substance (apoSASSAM) from mouse serum. J Biol Chem 261:12834-12840.
30. Hosokawa M, Abe T, Higuchi K, Shimakawa K, Omori Y, Matsushita T, Kogishi K, Deguchi E, Kishimoto Y, Yasuoka K, Takeda T. 1997. Management and design of maintenence of SAM strains of mice: An animal model for accelerated senescence and age-associated disorders. Exp Gerontol 32:111-116.
31. Hosokawa M, Ashida Y, Matsushita T, Takahashi K, Takeda T. 1993. Persistent hyaloid vascular system in age-related cataract in a SAM strain of mouse. Exp Eye Res 57:427-434.
32. Hosokawa M, Ashida Y, Nishikawa T, Takeda T. 1994. Accelerated aging of dermal fibroblast-like cells from senescence-accelerated mouse (SAM). 1. Acceleration of population aging in vitro. Mech Ageing Dev 74:65-77.
33. Hosokawa M, Ashida Y, Tsuboyama T, Chen WH, Takeda T. 1988. Cataract in senescence accelerated mouse (SAM). 2. Development of a new strain of mouse with late-appearing cataract. Exp Eye Res 47:629-640.
34. Hosokawa T, Hosono M, Hanada K, Aoike A, Kawai K, Takeda T. 1987a. Immune responses in newly developed short-lived SAM mice. II. Selectively impaired T-helper cell activity in in vitro antibody response. Immunology 62:425-429.
35. Hosokawa T, Hosono M, Higuchi K, Aoike A, Kasai K, Takeda T. 1987b. Immune responses in newly developed short-lived SAM mice. I. Age-associated early decline in immune activities of cultured spleen cells. Immunology 62:419-423.
36. Hosokawa M, Kasai R, Higuchi K, Takeshita S, Shimizu K, Hamamoto H, Honma A, Irino M, Toda K, Matsumura A, Matsushita M, Takeda T. 1984. Grading score system: A method for evaluation of the degree of senescence in senescence accelerated mouse (SAM). Mech Ageing Dev 26:91-102.
37. Hosono M, Hanada K, Toichi E, Naiki H, Higuchi K, Hosokawa T. 1997. Immune abnormality in relation to non-immune diseases in SAM mice. Exp Gerontol 32:181-195.
38. Ikegami S, Shumiya S, Kawamata H. 1992. Age-related changes in radialarm maze learning and basal forebrain cholinergic systems in senescence accelerated mice (SAM). Behav Brain Res 51:15-22.
39. Ingram DK, Kuo H, Hengemihle J, Shimada A, Tian M, Jucker M. 1994. Motor and memory performance of SAM P8, R1, and C57BL/6 mice: Assessing the relationship to PAS-positive granules in brain. In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 73-82.
40. Jilka RL, Weinstein RS,Takahashi K, Parfitt AM, Manolagas SC. 1996. Linkage of decreased bone mass with impaired osteoblaslogenesis in a murine model of accelerated senescence. J Clin Invest 97:1732-1740.
41. KaishoY, Miyamoto M, Shiho O, Onoue H, Kitamura Y, Nomura S. 1994. Expression of neurotropine genes in the brain of senescence-accelerated mouse (SAM) during postnatal development. Brain Res 647:139-144.
42. Kawaguchi S, Kishikawa M, Sakae M, Nakane Y. 1995. Age-related changes in basal dendrite and dendritic spine of hippocampal pyramidal neurons (CA1) among SAMP1TA/Ngs-quantitative analysis by the rapid Golgi method. Mech Ageing Dev 83:11-20.
43. Kawase M, Tsuda M, Matsuo T. 1989. Accelerated bone resorption in senescence-accelerated mouse (SAM-P/6). J Bone Miner Res 4:359-364.
44. Kishikawa M, Sakae M. 1997. Herbal medicine and the study on ageing in senescence accelerated mice (SAMP1TA/Ngs). Exp Gerontol 33:229-242.
45. Kitado H, Higuchi K, Takeda T. 1994. Molecular genetic characterization of the senescence-accelerated mouse (SAM) strains. J Gerontol 49:B247-B254.
46. Kitamura Y, Ohnuki T, Nomura Y. 1991. Effects of bifemelane hydrochroride, a brain function improver, on muscarinic receptors in the CNS of senescence-accelerated mouse. Jpn J Pharmacol 56:231-235.
47. Kitamura Y, Zhao XH, Ohnuki T, Takei M, Nomura Y. 1992. Age-related changes in transmitter glutamate and NMDA receptor/channels in the brain of senescence-accelerated mouse. Neurosci Lett 137:169-172.
48. Kohno A, Yonezu T, Matsushita M, Irino M, Higuchi K, Higuchi K, Takeshita S, Hosokawa M, Takeda T. 1985. Chronic food restriction modulates the advance of senescence in the senescence accelerated mouse (SAM). J Nutr 115:1259-1266.
49. Komura S, Yoshino K, Kondo K, Yagi K. 1988. Lipid peroxide levels in the skin of the senescence-accelerated mouse. J Clin Biochem Nutr 5:255-260.
50. Kunisada T, Higuchi K, Aota S, Takeda T, Yamagishi H. 1986. Molecular cloning and nucleotide sequence of cDNA for murine senile amyloid protein: Nucleotide substitutions found in apolipoprotein A-II cDNA of senescence accelerated mouse (SAM). Nucleic Acids Res 14:5729-5740.
51. Kurozumi M, Matsushita T, Hosokawa M, Takeda T. 1994. Age-related changes in lung structure and function in the senescence-accelerated mouse (SAM): SAM-P/1 as a new murine model of senile hyperinflation of lung. Am J Respir Crit Care Med 149:776-782.
52. Lee DW, Sohn HO, Lim HB, Lee YG, Chung MH. 1994. Comparison of sister chromatid exchange rates in bone marrow cells of SAMR1 and SAMP1 with age and effect of Korean ginseng extract on sister chromatid exchange rate. In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 129-131.
53. Liu J, Mori A. 1993. Age-associated changes in superoxide dismutase activity, thiobarbituric acid reactivity and reduced glutathione level in the brain and liver in senescence accelerated mice (SAM): A comparison with ddY mice. Mech Ageing Dev 71:23-30.
54. Manolagas SC, Jilka RL. 1995. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. Lancet 332:305-311.
55. Masoro EJ. 1990. Animal models in aging research. In: Schneider EL, Rowe JW, editors. Handbook of the Biology of Aging. San Diego: Academic Press. p 72-94.
56. Matsumura A, Higuchi K, Shimizu K, Hosokawa M, Hashimoto K, Yasuhira K, Takeda T. 1982. A novel amyloid fibril protein isolated from senescence-accelerated mice. Lab Invest 47:270-275.
57. Matsushita M, Tsuboyama T, Kasai R, Okumura H, Yamamuro T, Higuchi K, Higuchi K, Kohno A, Yonezu T, Utani A, Umezawa M, Takeda T. 1986. Age-related changes in bone mass in the senescence-accelerated mouse (SAM) SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis. Am J Pathol 215:276-283.
58. Meguro K, Yanai K, Sakai N, Sakurai E, Maeyama K, Sasaki H, Watanabe T. 1995. Effects of thioperamide, a histamine H3 antagonist, on the stepthrough passive avoidance response and histidine decarboxylase activity in senescence-accelerated mice. Pharmacol Biochem Behav 50:321-325.
59. Meguro K, Yanai K, Yokoyama H, Sakurai A, Maeyama K, Watanabe T, Matsuzawa T. 1992. Neurochemical studies on central histaminergic neuron system of senescence accelerated mice. Biogenic Amines 8:299-307.
60. Mitsuoka A, Hanada K. 1988. In vitro immune activities in senescence accelerated mice (SAM). In: Takeda T, Matsuo T, Akiguchi I, Hosokawa M, editors. Proceedings of the First SAM Kyoto Symposium. Kyoto: Fuji Printing Company, p 11-20.
61. Miyamoto M. 1997. Characteristics of age-related behavioral changes in senescence-accelerated mouse SAMP8 and SAMP10. Exp Gerontol 32:139-148.
62. Miyamoto M, Hirai K, Heya T, Nagaoka A. 1994. Effects of a sustained release formulation of thyrotropin-releasing hormone on behavioral abnormalities in senescence-accelerated mice. Eur J Pharmacol 271:357-366.
63. Miyamoto M, Kiyota Y, Nishiyama M, Nagaoka A. 1992. Senescence-accelerated mouse (SAM): Age-related reduced anxiety-like behavior in the SAM-P/8 strain. Physiol Behav 51:979-985.
64. Miyamoto M, Kiyota Y, Yamazaki N, Nagaoka A, Matsuo T, Nagawa Y, Takeda T. 1986. Age-related changes in learning and memory in the senescence-accelerated mouse (SAM). Behav Physiol 38:399-406.
65. Moriguchi T, Saito H, Nishiyama N. 1994. Effects of aged garlic extract (AGE) on impairments of learning and memory performances in senescence-accelerated mouse. In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 447-450.
66. Naiki H, Higuchi K, Hosokawa M, Takeda T. 1989. Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavine T. Anal Biochem 177:244-249.
67. Naiki H, Higuchi K, Nakakuki K, Takeda T. 1991. Kinetic analysis of amyloid fibril polymerization in vitro. Lab Invest 65:104-110.
68. Naiki H, Higuchi K, Shimada A, Takeda T, Nakakuki K. 1993. Genetic analysis of murine senile amyloidosis. Lab Invest 68:332-337.
69. Nakamoto H, Nakamura A, Goto S, Hosokawa M, Fujisawa H, Takeda T. 1994. Accumulation of oxidatively modified proteins in senescence-accelerated mouse SAMP11 and SAMR1. In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 137-140.
70. Nitta A, Naruhashi K, Umemura M, Hasegawa T, Furukawa S, Sekiguchi F, Ishibashi K, Nabeshima T. 1996. Age-related changes in learning and memory and cholinergic neuronal function in senescence accelerated mice (SAM). Behav Brain Res 72:49-55.
71. Nisitani S, Hosokawa M, Sasaki MS, Yasuoka K, Naiki H, Matsushita T, Takeda T. 1990. Acceleration of chromosome aberrations in senescence-accelerated strains of mice. Mut Res 237:221-228.
72. NomuraY, Kitamura Y, Zhao XH, Ohnuki T, Takei M, Yamanaka Y, Kitayama Y, Nishiya T. 1994. Neurochemical studies on aging in SAM brain. In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 83-88.
73. Nomura Y, Wang BX, Qi SB, Namba T, Kaneko S. 1989. Biochemical changes related to aging in the senescence-accelerated mouse. Exp Gerontol 24:49-55.
74. Ohnishi K, Tomimoto H, Akiguchi I, Seriu N, Kawamata T, Nakamura S, Kimura J, Nishio T, Higuchi K, Hosokawa M. 1995. Age-related decrease of nerve growth factor-like immunoreactivity in the basal forebrain of senescence-accelerated mice. Acta Neuropathol 90:11-16.
75. Ohta A, Hirano T, Yagi H, Tanaka S, Hosokawa M, Takeda T. 1989. Behavioral characteristics of the SAM-P/8 strain in Sidman active avoidance task. Brain Res 498:195-198.
76. Okamoto Y, Takahashi K, Toriyama K, Takeda N, Kitagawa K, Hosokawa M, Takeda T. 1995. Femoral peak bone mass and osteoclast number in an animal model of age-related spontaneous osteopenia. Anat Rec 242:21-28.
77. Oomura Y, Sasaki K, Li A, Yoshii H, Fukata Y, Yogo H, Kimura H, Tooyama I, Hanai K, Nomura Y, Kitamura Y, Yanaihara N. 1995. Acidic fibroblast growth factor protects memory and immunoreactivity impairment in senescence accelerated mice. Neurobiology 3:371-380.
78. Pearce L, Brown WH. 1960a. Hereditary premature senescence of the rabbit. I. Chronic form: General features. J Exp Med 111:485-504.
79. Pearce L, Brown WH. 1960b. Hereditary premature senescence of the rabbit. II. Acute form: General features. J Exp Med 111:505-516.
80. Popp DW. 1978. Use of congenic mice to study the genetic basis of degenerative disease. Birth Defects 14:261-279.
81. Riggs BL, Melton LJ. 1983. Evidence for two distinct syndromes of involutional osteoporosis. Am J Med 75:899-901.
82. Saitoh Y, Hosokawa M, Shimada A, Watanabe Y, Yasuda N, Murakami Y, Takeda T. 1995. Age-related cochlear degeneration in senescence-accelerated mouse. Neurobiol Aging 16:129-136.
83. Saitoh Y, Hosokawa M, Shimada A, Watanabe Y, Yasuda N, Takeda T, Murakami Y. 1994. Age-related hearing impairment in senescence-accelerated mouse (SAM). Hear Res 75:27-37.
84. Sashima M, Satoh H. 1994. Age-related changes of the periodontal tissues in senescence-accelerated mouse (S AM). In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 223-226.
85. Sashima M, Satoh H, Suzuki A. 1987. Incisor abnormality of senescence accelerated mouse (SAM). Gerodontology 6:145-148.
86. Sato E, Inoue A, Kurokawa T, Ishibashi S. 1994. Early changes in glucose metabolism in the cerebrum of senescence accelerated mouse: involvement of glucose transporter. Brain Res 637:133-138.
87. Sato E, Oda N, Ozaki N, Hashimoto S, Kurokawa T, Ishibashi S. 1996. Early and transient increase in oxidative stress in the cerebral cortex of senescence-accelerated mouse. Mech Ageing Dev 86:105-114.
88. Shimada A, Ohta A, Akiguchi I, Takeda T. 1992. Inbred SAM-P/10 as a mouse model of spontaneous, inherited brain atrophy. J Neuropathol Exp Neurol 51:440-450.
89. Shimada A, Ohta A, Akiguchi I, Takeda T. 1993. Age-related deterioration in conditional avoidance task in the SAM-P/10 mouse, an animal model of spontaneous brain atrophy. Brain Res 608:266-272.
90. Shimada A, Hosokawa M, Ohta A, Akiguchi I, Takeda T. 1994. Localization of atrophy-prone area in the aging mouse brain: Comparison between the brain atrophy model SAM-P/10 and the normal control SAM-R/1. Neuroscience 59:859-869.
91. Sprott RL. 1994. A brief history of the development of animal models for aging research: The place of SAM. In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 29-34.
92. Suda T, Miyama, Uchiyama Y, Katagiri T, Yamaguchi A, Sato T. 1994. Osteoporotic bone changes in SAMP6 are due to a decrease in osteoblast progenitor cells. In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 47-52.
93. Sugiyama H, Akiyama H, Akiguchi I, Kameyama M, Takeda T. 1987. Loss of dendritic spines in hippocampal CA1 pyramidal cells of senescence accelerated mouse (SAM): A quantitative Golgi study. Clin Neurol 27:841-845.
94. Takahashi H, Nishiyama M, Takami K, Miyamoto M, Nagaoka A. 1994a. Effects of chronic administration of idebenone on age-related behavioral disorders in senescence-accelerated mice (SAMP8). In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 427-430.
95. Takahashi K, Tsuboyama T, Matsushita M, Kasai R, Okumura H, Yamamuro T, Okamoto Y, Kitagawa K, Takeda T. 1994b. Effective intervention of low peak bone mass and bone modeling in the spontaneous murine model of senile osteoporosis, SAM-P/6, by Ca supplement and hormone treatment. Bone 15:209-215.
96. Takahashi K, Tsuboyama T, Matsushita M, Kasai R, Okumura H, Yamamuro T, Okamoto Y, Toriyama K, Kitagawa K, Takeda T. 1994c. Modification of strain-specific femoral bone density by bone marrow derived factors administered neonatally: A study on the spontaneously osteoporotic mouse, SAMP6. Bone Miner 24:245-255.
97. Takeda T, Hosokawa M, Higuchi K. 1991. Senescence-accelerated mouse (SAM): A novel murine model of accelerated senescence. J Am Geriatr Soc 39:911-919.
98. Takeda T, Hosokawa M, Higuchi K. 1994. Senescence-accelerated mouse (SAM): A novel murine model of aging. In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 15-22.
99. Takeda T, Hosokawa M, Takeshita S, Irino M, Higuchi K, Matsushita T, Tomita Y, Yasuhira K, Hamamoto H, Shimizu K, Ishii M, Yamamuro T. 1981. A new murine model of accelerated senescence. Mech Ageing Dev 17:183-194.
100. Takeda T, Matsushita T, Kurozumi M, Takemura K, Higuchi K, Hosokawa M. 1997. Pathobiology of senescence-accelerated mouse (SAM). Exp Gerontol 32:117-127.
101. Takemura M, Nakamura S, Akiguchi I, Ueno M, Oka N, Ishikawa S, Shimada A, Kimura J, Takeda T. 1993. B/A4 proteinlike immunoreactive granular structures in the brain of senescence-accelerated mouse (SAM). Am J Pathol 142:1887-1897.
102. Takeshita S, Hosokawa M, Irino M, Higuchi K, Shimizu K, Yasuhira K, Takeda T. 1982. Spontaneous age-associated amyloidosis in senescence-accelerated mouse (SAM). Mech Ageing Dev 20:13-23.
103. Teramoto S, Fukuchi Y, Uejima Y, Ito H, Orimo H. 1992. Age-related changes in GSH content of eyes in mice - a comparison of senescence-accelerated mouse (SAM) and C57BL/J mice. Comp Biochem Physiol 102A:693-696.
104. Teramoto S, Fukuchi Y, Uejima Y, Teramoto K, Oka T, Orimo H. 1994. A novel model of senile lung: Senescence-accelerated mouse (SAM). Am J Respir Crit Care Med 150:238-244.
105. Tobita M, Nakamura S, Nagano I, Itoh A, Itoyama Y. 1994. DNA single-stranded breaks in hippocampal regions of senescence-accelerated mice (SAMP8/Ta) detected by modified in situ nick translation procedure. In: Takeda T, editor. The SAM Model of Senescence. Amsterdam: Excerpta Medica. p 125-128.
106. Tsuboyama T, Matsushita M, Okumura H, Yamamuro T, Hanada K, Takeda T. 1989a. Modification of strain-specific femoral bone density by bone marrow chimerism in mice: A study on the spontaneously osteoporotic mouse (SAM-P/6). Bone 10:269-277.
107. Tsuboyama T, Takahashi K, Matsushita M, Okumura H, Yamamuro T, Umezawa M, Takeda T. 1989b. Decreased endosteal formation during cortical bone modelling in SAM-P/6 mice with a low peak bone mass. Bone Miner 7:1-12.
108. Tsuboyama T, Takahashi K, Yamamuro T, Hosokawa M, Takeda T. 1993. Cross- mating study on bone mass in the spontaneously osteoporotic mouse (SAM-P/6). Bone Miner 23:57-64.
109. Ueno M, Akiguchi I, Yagi H, Naiki H, Fujibayashi Y, Kimura J, Takeda T. 1993. Age-related changes in barrier function in mouse brain. I. Accelerated age-related increase of brain transfer of serum albumin in accelerated senescence prone SAM-P/8 mice with deficits in learning and memory. Arch Gerontol Geriatr 16:233-248.
110. Umezawa M, Hanada K, Naiki H, Chen WH, Hosokawa M, Hosono M, Hosokawa T, Takeda T. 1990. Effects of dietary restriction on age-related immune dysfunction in the senescence accelerated mouse (SAM). J Nutr 120:1393-1400.
111. Umezawa M, Ohta A, Tojo H, Yagi H, Hosokawa M, Takeda T. 1995. Dietary a-linolenate/linoleatc balance influences learning and memory in the senescence-accelerated mouse (SAM). Brain Res 669:225-233.
112. Vorbrodt AW, Dobrogowska DH, Ueno M, Tarnawski M. 1995. A quantita-tive immunocytochemical study of blood-brain barrier to endogenous albumin in cerebral cortex and hippocampus of senescence-accelerated mice (SAM). Folia Histochem Cytobiol 33:229-237.
113. Yagi H, Irino M, Matsushita T, Katoh S, Umezawa M, Tsuboyama T, Hosokawa M, Akiguchi I, Tokunaga R, Takeda T. 1989. Spontaneous spongy degeneration of the brain stem in SAM-P/8 mice, a newly developed memory-deficient strain. J Neuropathol Exp Neurol 48:577-590.
114. Yagi H, Katoh S, Akiguchi I, Takeda T. 1988a. Age-related deterioration of ability of acquistion in memory and learning in senescence accelerated mouse: SAM-P/8 as an animal model of disturbances in recent memory. Brain Res 474:86-93.
115. Yagi K, Yoshino K, Komura S, Kondo K, Ohishi N. 1988b. Lipid peroxide levels in the senescence-accelerated mouse (SAM). J Clin Biochem Nutr 5:21-27.
116. Yamagishi H, Kunisada T, Takeda T. 1985. Amplification of extrachromosomal small circular DNAs in a murine model of accelerated senescence. Mech Ageing Dev 29:101-103.
117. Yonezu T, Higuchi K, Tsunasawa S, Takagi S, Sakiyama F, Takeda T. 1986. High homology is present in the primary structures between murine senile amyloid protein (ASSAM) and human apolipoprotein A-II. FEBS Lett 203:149-152.
118. 5→gln) presents only in the senile amyloidosis-prone SAM-P/1 and SAM-P/2 mice. Lab Invest 57:65-70.
119. Yoshioka H, Yoshida H, Doi T, Muso E, Ohshio G, Higuchi K, Inada M, Miyake T, Kita T, Hamashima Y, Takeda T. 1989. Autoimmune abnormalities in a murine model of accelerated senescence. Clin Exp Immunol 75:129-135.
120. Zhao XH, Awaya A, Kobayashi H, Ohnuki T, Tokumitsu Y, NomuraY. 1990. Effects of repeated administrations of facteur thymique serique (FTS) on biochemical changes related to aging in senescence-accelerated mouse (SAM). Jpn J Pharmacol 53:311-319.
121. 3H] acetylcholine release from brain slice of senescence-accelerated mouse. Int J Dev Neurosci 10:121-129.
122. 3H] noradrenaline in brain slices of senescence-accelerated mouse. Int J Dev Neurosci 8:267-282.