Advantages of simplified Quantitative Morphometry using Stage Grouping analysis of Spermatogenic cycle for Evaluation of the Testicular Toxicity of Ethylene-1,2-Dimethanesulfonate in Rats

Journal of Toxicologic Pathology

Volumn 9, Issue 3, 1996, Pages 285-292

  Matsui, Hajime ^a   Toyoda, Kazuhiro ^b   Kawanishi, Toru ^b   Mitsumori, Kunitoshi ^b   Takahashi, Michihito ^b   Fukuhara, Kiyoshi ^b   Miyata, Naoki ^b  

^a Chemo Sero Therapeutic Research Institute   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

2 dimethanesulfonate; Ethylene 1; Testicular histopathology; Testicular toxicity

Indexed keywords

EID: 0006796043     PISSN: 09149198     EISSN: None     Source Type: Journal    
DOI: 10.1293/tox.9.285     Document Type: Article

References (15)

1. Kerr, JB, Donachie, K, and Rommerts, FFG: Selective destruction and regeneration of rat Leydig cells in vivo. A new method for the study of seminiferous tubular-interstitial tissue interaction. Cell Tissue Res 242: 145-156, 1985.
2. Molenaar, R, Rooij, DG, Rommerts, FFG, Reuveis, PJ, and Molen, HJ : Specific destruction of Leydig cells in mature rats after in vivo administration of ethane dimethyl sulfonate. Biol Reprod 33: 1213-1222, 1985.
3. Jackson, AE, OʹLeaiy, PC, Ayers, MM, and De Kretser, DM: The effects of ethylene dimethane sulphonate (EDS) on rat Leydig cells: Evidence to support a connective cell origin of Leydig cells. Biol Reprod 35: 425-437, 1986.
4. Jackson, NC, Jackson, H, Shanks, JH, Dixon, JS, and Lendon, RG: Study using in-vivo binding of 125I-labelled hCG, light and electron microscopy of the repopulation of rat Leydig cells after destruction due to administration of ethylene-1,2-dimethanesulphonate. J Reprod Fert 76. 1-10, 1986.
5. Matsui, H, Toyoda, K, Kawanishi, T, Mitsumori, K, Takahashi, M, Fukuhara, K, and Miyata, N: Direct toxic effects of ethylene-1,2-dimethanesulfonate (EDS) on the rat epididymis. J Toxicol Pathol 9: 65-72, 1996.
6. Clermont, Y: Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonia! renewal. Physiol Rev 52: 198-236,1972.
7. Takahashi, M and Matsúi, H : Mechanisms of testicular toxicity. J Toxicol Pathol 6: 161-174, 1993.
8. Jackson, CM, and Jackson, H : Comparative protective actions of gonadotropins and testosterone against the antispermatogenic action of ethane dimethanesulphonate. J Reprod Fert 71: 393-401, 1984.
9. Leblond, CP, and Clermont, Y: Definition of the stages of the cycle of the seminiferous epithelium in the rat Ann NY Acad Sci 55: 548-573, 1952.
10. Sharpe, RM, Maddocks, S, and Kerr, JB: Cell-cell interactions in the control of spermatogenesis as studied using Leydig cell destruction and testosterone replacement. Am J Anat 188 : 3-20, 1990.
11. Bartlett, JMS, Kerr, JB, and Sharpe, RM : The effect of selective destruction and regeneration of rat's Leydig cells on the intratesticular distribution of testosterone and morphology of seminiferous epithelium. J Androl 7: 240-253, 1986.
12. Schulz, R, Paris, F, Lembke, Peter, and Blum, V: Tesosterone immunoreactivity in the seminiferous epithelium of rat testis: Effect of treatment with ethane dimethanesulfonate. J Histochem Cytochem 37: 16671673, 1989.
13. Russell, LD, and Clermont, Y: Degeneration of germ cells in normal, hypophysectomized and hormone treated hypophysectomized rats. Anat Rec 187 : 347-366, 1977.
14. Dym, M, Raj, HGM, and Chemes, HE: Response of the testis to selective withdrawal of LH or FSH using antigonadotropic sera. In: The Testis in Normal and Infertile Men, RE Mancini, and L Martini, Eds, Academic Press, New York, 1977; pp. 13-36.
15. Russell, LD, Malone, JP, and Karpas, SL: Morphological pattern elicited by agents affecting spermatogenesis by disruption of its hormonal stimulation. Tissue Cell 13 : 369-380, 1981.