Effect of menthol derivatives on skin permeation of oxybutynin

Drug Delivery System

Volumn 12, Issue 5, 1997, Pages 327-333

  Okusa, Takashi ^a   Obata, Yasuko ^a   Takayama, Kozo ^a   Nagai, Tsuneji ^a   Higashiyama, Kimio ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

menthol derivatives; oxybutynin; percutaneous absorption; permeation enhancer

Indexed keywords

EID: 0006387856     PISSN: 09135006     EISSN: 18812732     Source Type: Journal    
DOI: 10.2745/dds.12.327     Document Type: Article

References (13)

1. Shinozaki Y, Nakai M, Iwata Y, Kasama T, Nakahama T, Akimoto Y, Urakubo G : Studies on the metabolic fate of oxybutynin hydrochloride (2). Absorption site and existing form in blood. Iyakuhin Kenkyu 17 : 1063-1069, 1986.
2. Okabe H, Obata Y, Takayama K, Nagai T : Percutaneous absorption enhancing effect and skin irritation of monocyclic monoterpenes. Drug Des. Delivery 6 : 229-238, 1990.
3. Takayama K, Kikuchi K, Obata Y, Okabe H, Machida Y, Nagai T : Terpenes as percutaneous absorption promoters. S. T. P. PHARMA SCIENCES 1 : 83-88, 1991.
4. Obata Y, Takayama K, Okabe H, Nagai T : Effect of cyclic monoterpenes on percutaneous absorption in the case of a water-soluble drug (diclofenac sodium). Drug Des. Delively 6 : 319-328, 1990.
5. Kikuchi K, Takayama K, Nagai T : Effects of d-limonene on the amounts of ethanol and indomethacin penetrated from aqueous gel ointment to rat skin. Chem. Pharm. Bull. 40 : 1906-1910, 1992.
6. Okabe H, Suzuki E, Saito T, Takayama K, Nagai T : Development of novel transdermal system containing d-limonene and ethanol as absorption enhancers. J. Contr. Rel. 32 : 243-247, 1994.
7. Ohara N, Takayama K, Machida Y, Nagai T : Combined effect of d-limonene and temperature on the skin permeation of kctoprofen. Int. J. Pharmaceut. 105 : 31-38, 1994.
8. Negishi J, Takayama K, Higashiyama K, Chida Y, Isowa K, Nagai T : Promoting effect of O-acylmenthol derivatives on the percutaneous absorption of ketoprofen in rats. S.T.P. PHARMA SCIENCES 5 : 156-161, 1995.
9. Elving PJ, Markowitz JM, Rosenthal I : Preparation of buffer systems of constant ionic strength. Anal Chem. 28 : 1179, 1956.
10. Okamoto H, Hashida M, Sezaki H : Structure-activity relationship of l-alyl- or l-alkenylazacycloalkanone derivatives as percutaneous penetration enhancers. J. Pharm. Sci. 77 : 418-424, 1988.
11. Yamaoka K, Tanigawa Y, Nakagawa T, Uno T : A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmakobio-Dyn. 4 : 879-885, 1981.
12. Aungst RJ, Nancy JR, Shefter E : Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxide and amides. Int. J. Pharm. 33 : 225-234, 1986.
13. Koyama Y, Bando H, Yamashita F, Sezaki H, Hashida M : Comparative analysis of percutaneous absorption enhancement by d-limonene and oleic acid based on a skin diffusion model. Pharm. Res. 11 : 377-382, 1994.