Alfentanil reduces the febrile response to interleukin-2 in humans

Critical Care Medicine

Volumn 28, Issue 5, 2000, Pages 1295-1300

  Negishi, Chiharu ^a   Kim, Jin Soo ^a   Lenhardt, Rainer ^a,c   Sessler, Daniel I ^a,b,c   Ozaki, Makoto ^d   Vuong, Kathleen ^a   Bastanmehr, Hiva ^a   Bjorksten, Andrew R ^e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^c Dept of Anesthesia/Gen Intensive ^*  (Austria)

^d TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^e ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Alfentanil; Cytokines; Fever; Hyperthermia; Interleukin 2; Opioid; Pyrogen; Temperature; Thermoregulation

Indexed keywords

ALFENTANIL; CYTOKINE; MU OPIATE RECEPTOR; RECOMBINANT INTERLEUKIN 2;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; CROSSOVER PROCEDURE; CYTOKINE PRODUCTION; DRUG BLOOD LEVEL; FEVER; HUMAN; HUMAN EXPERIMENT; HYPERTHERMIA; MALE; NORMAL HUMAN; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEDATION; THERMOREGULATION;

EID: 0006356528     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200005000-00006     Document Type: Article

References (61)

1. 1. Kurz A, Go JC, Sessler DI, et al: Alfentanil slightly increases the sweating threshold and markedly reduces the vasoconstriction and shivering thresholds. Anesthesiology 1995; 83:293-299
2. 2. Kurz A, Ikeda T, Sessler DI, et al: Meperidine decreases the shivering threshold twice as much as the vasoconstriction threshold. Anesthesiology 1997; 86:1046-1054
3. 3. Ikeda T, Sessler DI, Tayefeh F, et al: Meperidine and alfentanil do not reduce the gain or maximum intensity of shivering. Anesthesiology 1998; 88:858-865
4. 4. Rosow CE, Miller JM, Pelikan EW, et al: Opiates and thermoregulation in mice. I. Agonists. J Pharmacol Exp Ther 1980; 213: 273-283
5. 5. Rosow CE, Miller JM, Poulsen-Burke J, et al: Opiates and thermoregulation in mice. II. Effects of opiate antagonists. J Pharmacol Exp Ther 1982; 223:464-467
6. 6. Rosow CE, Miller JM, Poulsen-Burke J, et al: Opiates and thermoregulation in mice. III. Agonist-antagonists. J Pharmacol Exp Ther 1982; 223:468-475
7. 7. Rosow CE, Miller JM, Poulsen-Burke J, et al: Opiates and thermoregulation in mice. IV. Tolerance and cross-tolerance. J Pharmacol Exp Ther 1982; 223:702-708
8. 8. Weiss GR, Margolin KA, Aronson FR, et al: A randomized phase II trial of continuous infusion interleukin-2 or bolus injection interleukin-2 plus lymphokine-activated killer cells for advanced renal cell carcinoma. J Clin Oncol 1992; 10:275-281
9. 9. Thompson JA, Shulman KL, Benyunes MC, et al: Prolonged continuous intravenous infusion of interleukin-2 and lymphokine-activated killer-cell therapy for metastatic renal cell carcinoma. J Clin Oncol 1992; 10: 960-968
10. 10. Greesten PF, Hermann GG, van der Maase H, et al: Treatment of metastatic renal cell carcinoma by continuous intravenous infusion of recombinant interleukin-2: A single-center phase II study. J Clin Oncol 1992; 10:753-759
11. 11. Kovacs JA, Baseler M, Dewar RJ, et al: Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. N Engl J Med 1995; 332:567-575
12. 12. Kovacs JA, Vogel S, Albert JM, et al: Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus. N Engl J Med 1996; 335: 1350-1356
13. 13. Mier JW, Vachino G, Van Der Meer JWM, et al: Induction of circulating tumor necrosis factor (TNF-α) as the mechanism for the febrile response to interleukin-2 (IL-2) in cancer patients. J Clin Immunol 1988; 8:426-436
14. 14. Heslop HE, Gottlieb DJ, Bianchi ACM, et al: In vivo induction of γ interferon and tumor necrosis factor by interleukin-2 infusion following intensive chemotherapy or autologous marrow transplantation. Blood 1989; 74:1374-1380
15. 15. Kasid A, Director EP, Rosenberg SA: Induction of endogenous cytokine-mRNA in circulating peripheral blood mononuclear cells by IL-2 administration to cancer patients. J Immunol 1989; 143:736-739
16. 16. Davatelis G, Wolpe SD, Sherry B, et al: Macrophage inflammatory protein-1: A prostaglandin-independent endogenous pyrogen. Science 1989; 243:1066-1068
17. 17. Negishi C, Lenhardt R, Sessler DI, et al: Desflurane reduces the febrile response to interleukin-2 administration. Anesthesiology 1998; 88:1162-1169
18. 18. Siegel JP, Puri RK: Interleukin-2 toxicity. J Clin Oncol 1991; 9:694-704
19. 19. Kissin I, Brown PT, Robinson A, et al: Acute tolerance in morphine analgesia: Continuous infusion and single injection in rats. Anesthesiology 1991; 74:166-171
20. 20. Crankshaw DP, Karasawa F: A method for implementing programmed infusion of theiopentone and methohexitone with a simple infusion pump. Anaesth Int Care 1989; 17:496-499
21. 21. Scott JC, Stanski DR: Decreased fentanyl and alfentanil dose requirements with age: A simultaneous pharmacokinetic and pharmacodynamic evaluation. J Pharmacol Exp Ther 1987; 240:159-166
22. 22. Sessler DI, McGuire J, Moayeri A, et al: Isoflurane-induced vasodilation minimally increases cutaneous heat loss. Anesthesiology 1991; 74:226-232
23. 23. Sessler DI, Rubinstein EH, Moayeri A: Physiological responses to mild perianesthetic hypothermia in humans. Anesthesiology 1991; 75:594-610
24. 24. Bjorkman S, Stanski DR: Simultaneous determination of fentanyl and alfentanil in rat tissues by capillary column gas chromatography. J Chromatogr 1988; 433:95-104
25. 25. Martin WR: Pharmacology of opioids. Pharmacol Rev 1983; 35:283-323
26. 26. Denman WT, Rosow D, Hennessy D, et al: Miotic effects of alfentanil and fentanyl occur at very low doses. Abstr. Anesthesiology 1997; 87:A316
27. 27. Belani KB, Sessler DI, Larson M, et al: The pupillary light reflex: Effects of anesthetics and hyperthermia. Anesthesiology 1993; 79: 23-27
28. 28. de Waal Malefyt R, Haanen J, Spits H, et al: Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via down-regulation of class II major histocompatibility complex expression. J Exp Med 1991; 174: 915-924
29. 29. de Waal Malefyt R, Abrams J, Bennett B, et al: Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174:1209-1220
30. 30. Fiorentino DF, Zlotnik A, Mosmann TR, et al: IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991; 147: 3815-3822
31. 31. Nava F, Calapai G, Facciola G, et al: Effects of interleukin-10 on water intake, locomotory activity, and rectal temperature in rat treated with endotoxin. Int J Immunopharmacol 1997; 19:31-38
32. 32. Matthews JNS, Altman DG, Campbell MJ, et al: Analysis of serial measurements in medical research. BMJ 1990; 300:230-235
33. 33. Andrews CJ, Sinclair M, Prys-Roberts C, et al: Ventilatory effects during and after continuous infusion of fentanyl or alfentanil. Br J Anaesth 1983; 55:2118-2168
34. 34. Westmoreland CL, Sebel PS, Gropper A: Fentanyl or alfentanil decreases the minimum alveolar anesthetic concentration of isoflurane in surgical patients. Anesth Analg 1994; 78:23-28
35. 35. Shapiro BA, Warren J, Egol AB, et al: Practice parameters for intravenous analgesia and sedation for adult patients in the intensive care unit: An executive summary. Crit Care Med 1995; 23:1596-1600
36. 36. Fuller CA, Horwitz BA, Horowitz JM: Shivering and nonshivering thermogenic responses of cold-exposed rats to hypothalamic warming. Am J Physiol 1975; 228:1519-1524
37. 37. Foster DO, Frydman ML: Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline. Can J Physiol Pharmacol 1978; 56:110-122
38. 38. Dawkins MJR, Scopes JW: Non-shivering thermogenesis and brown adipose tissue in the human new-born infant. Nature 1965; 206:201-202
39. 39. Brück K, Baum E, Schwennicke HP: Cold-adaptive modifications in man induced by repeated short-term cold-exposures and during a 10-day and -night cold-exposure. Pflugers Arch 1976; 363:125-133
40. 40. Hynson JM, Sessler DI, Moayeri A, et al: Absence of nonshivering thermogenesis in anesthetized humans. Anesthesiology 1993; 79:695-703
41. 41. Jessen K: An assessment of human regulatory nonshivering thermogenesis. Acta Anaesthesiol Scand 1980; 24:138-143
42. 42. Jessen K, Rabøl A, Winkler K: Total body and splanchnic thermogenesis in curarized man during a short exposure to cold. Acta Anaesthesiol Scand 1980; 24:339-344
43. 43. Lenhardt R, Negishi C, Sessler DI, et al: Paralysis only slightly reduces the febrile response to interleukin-2 during isoflurane anesthesia. Anesthesiology 1998; 89:648-656
44. 44. Dicker A, Ohlson KB, Johnson L, et al: Halothane selectively inhibits nonshivering thermogenesis. Anesthesiology 1995; 82:491-501
45. 45. Matsukawa T, Kurz A, Sessler DI, et al: Propofol linearly reduces the vasoconstriction and shivering thresholds. Anesthesiology 1995; 82:1169-1180
46. 46. Xiong J, Kurz A, Sessler DI, et al: Isoflurane produces marked and non-linear decreases in the vasoconstriction and shivering thresholds. Anesthesiology 1996; 85:240-245
47. 47. Annadata RS, Sessler DI, Tayefeh F, et al: Desflurane slightly increases the sweating threshold, but produces marked, non-linear decreases in the vasoconstriction and shivering thresholds. Anesthesiology 1995; 83: 1205-1211
48. 48. Talke P, Tayefeh F, Sessler DI, et al: Dexmedetomidine does not alter the sweating threshold, but comparably and linearly reduces the vasoconstriction and shivering thresholds. Anesthesiology 1997; 87: 835-841
49. 49. Delaunay L, Bonnet F, Liu N, et al: Clonidine comparably decreases the thermoregulatory thresholds for vasoconstriction and shivering in humans. Anesthesiology 1993; 79: 470-474
50. 50. Delaunay L, Herail T, Sessler DI, et al: Clonidine increases the sweating threshold, but does not reduce the gain of sweating. Anesth Analg 1996; 83:844-848
51. 51. Cox B, Ary M, Chesarek W, et al: Morphine hyperthermia in the rat: An action on the central thermostats. Eur J Phamacol 1976; 36:33-39
52. 52. Lotti VJ, Lomax P, George R: Temperature responses in the rat following intracerebral microinjection of morphine. J Pharmacol Exp Ther 1965; 150:135-139
53. 53. Fitton AG, Pertwee RG: Changes in body temperature and oxygen consumption rate of conscious mice produced by intrahypothalamic and intracerebroventricular injections of Δ9-tetrahydrocannabinol. Br J Pharmacol 1982; 75:409-414
54. 54. Gray JA, Goodwin GM, Heal DJ, et al: Hypothermia induced by baclofen, a possible index of GABAB receptor function in mice, is enhanced by antidepressant drugs and ECS. Br J Pharmacol 1987; 92:863-870
55. 55. Poterack KA, Kampine JP, Schmeling WT: The effect of halothane on thermosensitive neurons in the preoptic region of the anterior hypothalamus in acutely instrumented cats. Anesthesiology 1991; 75:625-633
56. 56. Farber NE, Poterack KA, Kampine JP, et al: The effects of halothane, isoflurane, and enflurane on thermoregulatory responses in the neuraxis of cats. Anesthesiology 1994; 80:879-891
57. 57. Farber NE, Schmidt JE, Kampine JP, et al: Halothane modulates thermosensitive hypothalamic neurons in rat brain slices. Anesthesiology 1995; 83:1241-1253
58. 58. Sessler DI, Hynson J, McGuire J, et al: Thermoregulatory vasoconstriction during isoflurane anesthesia minimally decreases heat loss. Anesthesiology 1992; 76:670-675
59. 59. Washington D, Sessler DI, Moayeri A, et al: Thermoregulatory responses to hyperthermia during isoflurane anesthesia in humans. J Appl Physiol 1993; 74:82-87
60. 60. Smith KA: Interleukin-2: Inception, impact and implications. Science 1988; 240: 1169-1176
61. 61. Kotanidou A, Choi AM, Winchurch RA, et al: Urethan anesthesia protects rats against lethal endotoxemia and reduces TNF-α release. J Appl Physiol 1996; 81:2305-2311