Conformation of a novel tetrapeptide inhibitor NH2-D-Trp-D-Met- Phe(pCl)-Gla-NH2 bound to farnesyl-protein transferase

Journal of Peptide Research

Volumn 54, Issue 1, 1999, Pages 66-73

  Bogusky, Michael J ^a   Culberson, J C ^a   Pitzenberger, S M ^a   Garsky, V M ^a   Wallace, A ^b   Pessi, A ^b   Koblan, K S ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Ist di Ric di Biologia M ^*  (Italy)

Author keywords

Farnesyl protein transferase; Inhibitor; Ligand conformation; NMR; Transferred nuclear Overhauser spectroscopy

Indexed keywords

PROTEIN FARNESYLTRANSFERASE; TETRAPEPTIDE;

ARTICLE; COMPETITIVE INHIBITION; CONFORMATION; ENZYME BINDING; ENZYME SUBSTRATE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE ANALYSIS; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ALKYL AND ARYL TRANSFERASES; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OLIGOPEPTIDES;

ANIMALIA;

EID: 0006197796     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.1999.00085.x     Document Type: Article

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