High throughput screen for inhibitors of bacterial DNA topoisomerase I using the scintillation proximity assay

Journal of Biomolecular Screening

Volumn 1, Issue 3, 1996, Pages 135-143

  Lerner, Claude G ^a   Chiang Saiki, Anne Y ^a   Mackinnon, A Craig ^a   Xuei, Xiaoling ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0005920219     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1177/108705719600100307     Document Type: Article

References (8)

1. Neu, H. C. (1992). The crisis in antibiotic resistance. Science 257:1064.
2. Hooper, D. C., Wolfson, J. S. (1991). Fluoroquinolone antimicrobial agents. N. Engl. J. Med. 324:384.
3. Luttinger, A. (1995). The twisted 'life' of DNA in the cell: Bacterial topoisomerases. Mol. Microbiol. 15:601.
4. Sutcliffe, J. A., Gootz, T. D., Barrett, J. F. (1989). Biochemical characteristics and physiological significance of major DNA topoisomerases. Antimicrob. Agents Chemother. 33:2027.
5. Wang, J. C. (1991). DNA topoisomerases: why so many? J. Biol. Chem. 266:6659.
6. Liu, L. F., Wang, J. C. (1987). Supercoiling of the DNA template during transcription. Proc. Natl. Acad. Sci. U.S.A. 83:7024.
7. Drolet, M., Bi, X., Liu, L. F. (1994). Hypernegative supercoiling of the DNA template during transcription elongation in vitro. J. Biol. Chem. 269:2068.
8. Drolet, M., Phoenix, P., Menzel, R., Massé, E., Liu, L. F., Crouch, R. J. (1995). Overexpression of RNase H partially complements the growth defect of an Escherichia coli topA mutant: R-loop formation is a major problem in the absence of DNA topoisomerase. I. Proc. Natl. Acad. Sci. U.S.A. 92:3526.