Hydrolysis of the cis-Phenyl Ester of Thymidine 3′,5′-Cyclic Monophosphate: PH-Dependent Competition between Depyrimidination and Phosphotriester Hydrolysis via CO and PO Bond Ruptures

Journal of Organic Chemistry

Volumn 62, Issue 4, 1997, Pages 893-898

  Varila, Jaana ^a   Hankamäki, Teemu ^a   Oivanen, Mikko ^a   Koole, Leo H ^b   Lönnberg, Harri ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0005714106     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo960693v     Document Type: Article

References (21)

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12. A trace of hydrolysis products, mainly 3, was also formed due to incomplete exclusion of moisture, when the reactions were followed at 363.2 K for 5 d in sealed tubes. No sign of hydrolysis products was observed when the alkaline methanolysis was followed at 298.2 K for 1 h.
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