A comparative bear model for immobility-induced Osteopenia

Ursus

Volumn 10, Issue , 1998, Pages 507-520

  Milbury, Paul E ^a   Vaughan, Michael R ^b   Farley, Sean ^c   Matula Jr , George J ^d   Convertino, Victor A ^e   Matson, Wayne R ^a  

^a ESA Biosciences Inc   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c WASHINGTON STATE UNIVERSITY   (United States)

^d MAINE DEPARTMENT OF INLAND FISHERIES AND WILDLIFE   (United States)

^e Air Force Materiel Command   (United States)

Author keywords

Amino acids; Bear; Bone; Comparative study; Fasting; Hibernation; Human; Immobility; Metabolic patterns; Metabolism; Osteopenia; Protein metabolism; Ursidae

Indexed keywords

ANIMAL; ANIMAL MODEL; ARTICLE; BEAR; BED REST; BLOOD; BONE DEMINERALIZATION; COMPARATIVE STUDY; ENERGY METABOLISM; FACTUAL DATABASE; HIBERNATION; HUMAN; IMMOBILIZATION; METABOLIC BONE DISEASE; METABOLISM; NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER; OSTEOPOROSIS; PHYSIOLOGY; SEASON;

NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER;

ANIMALS; BED REST; BONE DEMINERALIZATION, PATHOLOGIC; BONE DISEASES, METABOLIC; DATABASES, FACTUAL; ENERGY METABOLISM; HIBERNATION; HUMANS; IMMOBILIZATION; MODELS, ANIMAL; OSTEOPOROSIS; SEASONS; URSIDAE;

EID: 0005671065     PISSN: 15376176     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. ABADIE, J.M., B. WRIGHT, G. CORREA, E.S. BROWNE, J.R. PORTER, AND F. SVEC. 1993. Effect of dehydroepiandrosterone on neurotransmitter levels and appetite regulation of the obese Zucker rat: The obesity research program. Diabetes 42:662-669.
2. ADDIS, T., L.J. Poo, AND W.LEW. 1936. The quantities of protein lost by the various organs and tissues of the body during a fast. J. Biol. Chem. 115:111-116.
3. AZIZI, F., J.E. MANNIX, D. HOWARD, AND R.A. NELSON. 1979. Effect of winter sleep on pituitary-thyroid axis in American black bear. Am. J. Physiol. 237:E227-E230.
4. BAXTER, M.A., AND M.C. SHEPPARD. 1991. Endocrinology. Postgraduate Med. J. 67:23-32.
5. BEAL, M.F., W.R. MATSON, K.J. SWARTZ, P.H. GAMACHE, AND E.D. BIRD. 1990. Kynurenine pathway measurements in Huntington's disease striatum: evidence for reduced formation of kynurenic acid. J. Neurochem. 55:1327-1339.
6. BIRD, E.D., W.R. MATSON, M.F. BEAL, AND T. OGAWA. 1990. Patterns of tyrosine and tryptophan metabolites in controls and various degenerative disorders. Pages 529-535 in T. Nagatsu, ed. Basic, clinical and therapeutic aspects of Alzheimer's and Parkinson's diseases. Volume I. Plenum Press, New York, N.Y.
7. BOOTH, D.A. 1981. The physiology of appetite. Brit. Med. Bull. 37:135-140.
8. BREISCH, S.T., ZEMLAN, F.P., AND B.G. HOEBEL. 1976. Hyperphagia and obesity following serotonin depletion by intraventricular p-chlorophenylalanine. Science 192:382-385.
9. DELMAS, P.D. 1991. Biochemical markers of bone turnover: methodology and clinical use in osteoporosis. Am. J. Med. 91:59S-63S.
10. DEMERS, L.M., AND M. KLEEREKOPER. 1994. Recent advances in biochemical markers of bone turnover. Clin. Chem. 40:1994-1995.
11. DUNN.M.A., S.K.HOUTZ, AND E.W. HARTSOOK. 1982. Effects of fasting on muscle protein turnover, the composition of weight loss, and energy balance of obese and nonobese Zucker rats. J. Nutr. 112:1862-1875.
12. EBLING, P.R., J.M. PETERSON, AND B.L.RIGGS. 1992. Utility of type I procollagen propeptide assays for assessing abnormalities in metabolic bone diseases. J. Bone and Mineral Res. 7:1243-1250.
13. FELDBERG, W., AND R.D. MYERS. 1964. Effects on temperature of amines injected into the central ventricles. A new concept of temperature regulation. J. Physiol. (London) 17, 3:226-326.
14. FLOYD, T., R. A. NELSON, AND G.F. WYNNE. 1990. Calcium and bone metabolic homeostasis in active and denning black bears, Ursus americanus. Clin. Orthopedics 255:301-309.
15. GHARIB, C., G. GAUQUELIN, J.M. PEQUINOT, G. GEELEN, C. BEOLLON, AND A. GÜELL. 1988. Early hormonal effects of head-down tilt -10° in humans. Aviation Space Environ. Med. 59:624-629.
16. GLASS, J.D., AND L.C.H. WANG. 1979. Effects of central injection of biogenic amines during arousal from hibernation. Am. J. Physiol. 236:R162-R167.
17. GOODMAN, M.N., P.R. LARSON, M.M. KAPLAN, T.T. AOKI, U.R. YOUNG, AND N.B. RUDERMAN. 1980. Starvationintherat.il. Effect of age and obesity on protein sparing and fuel metabolism. Am. J. Physiol. 239:E277-E286.
18. HALLER, A.C., AND M.L. ZLMNY. 1977. Effects of hibernation on interradicular alveolar bone. J. Dental Res. 56:1552-1557.
19. HARMAN, H.H. 1967. Modem factor analysis. Univ. Chicago Press, Chicago, Ill. 518pp.
20. HARPER, A.E. 1986. Enzymatic basis for adaptive changes in amino acid metabolism. Pages 409-414 in T.G. Taylor and N.K. Jenkins, eds. Proc. XIII Int. Congr. Nutr. John Libbey, London, U.K.
21. -, AND E. BENJAMLN. 1984. Relationship between intake and the rate of oxidation of leucine and a-ketolsocaproate in vivo in the rat. J. Nutr. 14:431-510
22. HARTIGAN, J.A. 1975. Clustering algorithms. John Wiley and Sons, New York, N.Y. 351pp.
23. -, AND M.A. WONG. 1979. A K-means clustering algorithms. Appl. Stat. 28:100-108.
24. HASSARD, T.H. 1991. Understanding biostatistics. Mosby, Inc., St. Louis, Mo. 85pp.
25. HOCK, R.J. 1960. Seasonal variations in physiological functions of arctic ground squirrels and black bears. Bull. Mus. Comp. Zool. 101:289-299.
26. HORDON, L.D., AND V. WRIGHT. 1994. Endocrine disorders. Current Opinion in Rheumatology 6:95-100.
27. KiLDUFF, T.S., S.S. BOWERSOX, K.F. FAULL, L. ZELLER-DEAMICIS, C.M. RADEKE, R.D. CIARANELLO, H.C. HELLER, J.D. BARCHAS, AND W.C. DEMENT. 1987. Modulation of activity of the striatal dopaminergic system during the hibernation cycle. J. Neurosci. 7:2732-2736.
28. LLV, L.H., AND E.B. PIVORUN. 1990. Hypothalamic monoamines and their metabolites in the deermouse, Peromyscus maniculatus, during daily torpor. J. Neural Transmission. Gen. Sect. 79:11-18.
29. LUNDBERG, D.A., R.A. NELSON, H.W. WAHNER, AND J.D. JONES. 1976. Protein metabolism in the black bear before and during hibernation. Mayo Clin. Proc. 51:716-722.
30. MATSON, W.R., A. BOUCKOMS, C. SVENDSEN, M.F. BEAL AND E.D. BIRD. 1990. Generating and controlling multiparameter data bases for biochemical correlates of disorders. Pages 513-516 in T. Nagatsu, ed. Basic clinical and therapeutic aspects of Alzheimer's and Parkinson's Diseases. Plenum Press, New York, N.Y.
31. MCGOWAN, J.A. 1993. Osteoporosis: assessment of bone loss and remodeling. Aging Clin. Exp. Res. 5:81-93.
32. MiLBURY, P.E. 1992. A comparative bear model of immobility osteopenia. Small Business Innovative Research Grant Phase I Final Rep. and Phase II Appl. R44 AG 13317-13402 Natl. Inst. Aging, Natl. Inst. Health. 73pp.
33. MORLEY, J.E., AND A.S. LEVLNE. 1983. The central control of appetite. Lancet 1(8321):398-461.
34. MORTLMORE, G.E. 1987. Intracellular protein catabolism and its control during nutrient deprivation and supply. Ann. Rev. Nutr. 7:539-564,
35. -, J.J. WERT, JR., AND C.E. ADAMS. 1988. Modulation of the amino acid control of hepatic protein degradation by caloric deprivation: Two modes of alanine co-regulation. J. Biol. Chem. 263:19545-19551.
36. NATIONAL AERONAUTICS AND SPACE ADMINISTRATION. 1991. Proceedings of the NASA symposium on the influence of gravity and activity on muscle and bone. J. Biomech. 24:1-177.
37. NELSON, R.A., T.D.I. BECK, AND D.L. STEIGER. 1984. Ratio of serum urea to serum creatinine in wild black bears. Science 226:841-842.
38. -, D.L. STEIGER, AND T.D.I. BECK. 1983. Neuroendocrine and metabolic interactions in hibernating black bear. Acta Zool. Fenn. 174:137-141.
39. NOACH, E.L. 1994. Appetite regulation by serotoninergic mechanisms and effects of d-fenfluramine. Netherlands J. Med. 45:123-133.
40. RAISZ, L.G. 1988. Local and systemic factors in the pathogenesis of osteoporosis. New Engl. J. Med. 318:818.
41. RHS, B.J. 1991. Biochemical markers of bone turnover in diagnosis and assessment of therapy. Am. J. Med. 9L64S-68S.
42. ROLLS, E.T. 1981. Central nervous mechanisms related to feeding and appetite. Brit. Med. Bull. 37:131-134.
43. SALZMAN, S.K., C. LLADOS-ECKMAN, AND A.L. BECKMAN. 1985. In vivo analysis of dopamine and its metabolites in the caudate nucleus during euthermia and hibernation. Brain Res. 343:95-103.
44. SELBY, P.L., AND R.M. FRANCIS. 1988. Endocrinology and osteoporosis. J. Endocrin. 117:1-3.
45. SMITH, G.P., K.A. BOURBOAI, C. JEROME, AND K.J. SLMANSKY. 1987. Sham feeding of sucrose increases the ratio of 3,4- dihydroxyphenylacetic acid to dopamine in the hypothalamus. Pharmacol. Biochem. Behav. 6:585-591.
46. TAMBURLNO, G., AND C.E. FIORE. 1990. Plasmatic markers of bone metabolism. Ann. Italian Med. Int. 5:296-302.
47. WURTMAN, R.J. 1988. Neurotransmitters, control of appetite, and obesity. Curr. Concepts Nutr. 16:27-34.