A generic recognition-based approach to the acceleration of cycloaddition reactions

Organic Letters

Volumn 4, Issue 2, 2002, Pages 273-276

  Howell, Sarah J ^a   Spencer, Neil ^b   Philp, Douglas ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE;

EID: 0005608214     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol017044c     Document Type: Article

References (30)

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28. 1, B, and 1 are dissolved in the same vessel at the start of the reaction.
29. 3. All calculations were performed on a Silicon Graphics O2 workstation. Conformational searching was carried out using 10 000 step Monte Carlo simulations, and all conformation located within 50 kJ of the global minimum were minimized. The sets of conformations generated by these searches were then filtered appropriately using the analysis tools available within Macromodel.
30. a value measured for [5-7] suggests that the structure of 5 is poorly adapted to bind 7 strongly.