Mucosal adjuvant effect of genetically modified cholera toxin and Escherichia coli heat-labile enterotoxin derivatives

Research in Immunology

Volumn 149, Issue 1, 1998, Pages 33-35

  De Magistris, M T ^a  

^a CHIRON VACCINES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0005542332     PISSN: 09232494     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0923-2494(98)80040-0     Document Type: Article

References (7)

1. Domenighini, M., Magagnoli, C., Pizza, M. & Rappuoli, R. (1994), Common features of the NAD-binding and catalytic site of ADP-ribosylating toxins. Mol. Microbiol., 14, 41-50.
2. Pizza, M., Domenighini, M., Hol, W., Giannelli, V., Fontana, M.R., Giuliani, M.M., Magagnoli, C., Peppoloni, S., Manetti, R. & Rappuoli, R. (1994), Probing the structure-activity relationship of Escherichia coli LT-A by site-directed mutagenesis. Mol. Microbiol., 14, 51-60.
3. Fontana, M.R., Manetti, R., Giannelli, V., Magagnoli, C., Marchini, A., Olivieri, R., Domenighini, M., Rappuoli, R. & Pizza, M. (1995), Construction of non-toxic derivatives of cholera toxin and characterization of the immunological response against the A subunit. Infect. Immun., 63, 2356-2360.
4. Douce, G., Turcotte, C., Cropley, I., Roberts, M., Pizza, M., Domenighini, M., Rappuoli, R. & Dougan, G. (1995), Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants. Proc. Natl. Acad. Sci. USA 92, 1644-1648.
5. Di Tommaso, A., Saletti, G., Pizza, M., Rappuoli, R., Dougan, G., Abrignani, S., Douce, G. & De Magistris, MT. (1996), Induction of antigen-specific antibodies in vaginal secretions using a non-toxic mutant of LT as a mucosal adjuvant. Infect. Immun., 64, 974-979.
6. Marchetti, M., Rossi, M., Giannelli, V., Giuliani, M.M., Pizza, M., Censini, S., Covacci, A., Massari, P., Pagliaccia, C., Manetti, R., Telford, J.L., Douce, G., Dougan, G., Rappuoli, R. & Ghiara, P. (1998), Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant. Vaccine, 16, 33-37.
7. Douce, G., Fontana, M., Pizza, M., Rappuoli, R. & Dougan, G. (1997), Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin. Infect. Immun. 65, 2821-2828.