TRNA-embedded hammerhead ribozymes mediate destruction of HBV (subtype adr) in vitro

Acta Biochimica et Biophysica Sinica

Volumn 30, Issue 5, 1998, Pages 437-438

  Zheng, Wen Chao ^a   Qi, Guo Rong ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Hammerhead ribozyme; HBV (subtype adr); RNA trimming plasmid; TRNA embedded ribozyme

Indexed keywords

EID: 0005197109     PISSN: 05829879     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Bauer G, Valdez P, Kearns K et al. Inhibition of human immunodeficiency virus-1 (HIV-1) replication after transduction of granulocyte colony-stimulating factor-mobilized CD34 (+) cells from HIV-1-infected donors using retroviral vectors containing anti-HIV-1 genes. Blood, 1997, 89: 2259-2267
2. Gebhard J R, Perry CM, Mahadeviah S et al. Use of a nonviral vector to express a chimeric tRNA-ribozyme against lymphocytic choriomeningitis virus-cytoplasmic accumulation of a catalytically competent transcript but minimal antiviral effect. Antisense & Nucleic Acid Drug Development, 1997, 7: 3-11
3. Albuquerquesilva J, Devos M J, Bollen A et al. Hairpin and hammerhead ribozymes directed towards the mumps virus nucleocapsid RNA-specific cleavage of a small synthetic RNA substrate and full-length mRNA. Virus Genes, 1996, 13: 211-219
4. Lieber A, He C Y, Polyak S J et al. Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes. J Virol, 1996, 70: 8782-8791
5. Yuyama N, Ohkawa J, Inokuchi Y et al. Construction of a tRNA-embedded-ribozyme trimming plasmid. Biochem Biophys Res Commun, 1992, 186: 1271-1279
6. Cotten M, Birnsteiel M L. Ribozyme mediated destruction of RNA in vivo. EMBO J, 1989, 8: 3861-3866
7. He Y K, Lu C D, Qi G R. In vitro cleavage of HPV16 E6 and E7 RNA fragments by synthetic ribozymes and transcribed ribozymes from RNA-trimming plasmid. FEBS Lett, 1993, 322: 21-24
8. (Zhang X L, Zhang F, Qi G R et al.), Ribozyme (High Technology Letters), 1997, 7: 23-27
9. (Huang Y Z, Kong Y Y, Wang Y et al.): HPV 16 E7 ribozyme CV-1 (Chinese Journal of Biotechnology), 1996, 121 385-389
10. (Jin Z Y, Qi G R, Lu C D): (Acta Biologiae Experimentalis Sinica), 1996, 29: 351-356
11. Sambrook J, Fritsch E F, Maniatis T. Molecular Cloning: A Laboratory Manual, 2nd ed. New York; Cold Spring Harbor Laboratory Press, 1989
12. (Lu C D, Chen N A, Qi G R): (Acta Biochimica et Biophysica Sinica), 1996, 28: 279-285
13. Wang Y, Li Z P. Hepatitis B virus genome, Structure and function. In, Wen Y M, Xu Z Y, Melnick J L eds. Viral Hepatitis in China: Problems and Control Strategies, Basel: Karger Press, 1992, 1-19. Monographs Virology, 19
14. Fedor M J, Uhlenbeck O C. Substrate sequence effects on "hammerhead" RNA catalytic efficiency. Proc Natl Acad Sci USA, 1990, 87: 1668-1672