Comparison of urinary creatine with other biomarkers for the detection of 2-methoxyethanol-induced testicular damage

Biomarkers

Volumn 1, Issue 3, 1996, Pages 190-195

  Draper, Ruth P ^a   Creasy, Dianne M ^b   Timbrell, John A ^c  

^a SOUTHMEAD HOSPITAL   (United Kingdom)

^b Pharmaco LSR Ltd   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

2 methoxethanol; Creatine; Testicular toxicity; Urinary biomarker

Indexed keywords

EID: 0005033022     PISSN: 1354750X     EISSN: None     Source Type: Journal    
DOI: 10.3109/13547509609079356     Document Type: Review

References (17)

1. CREASY, D. M., FLYNN, J. C., GRAY, T. J. B. AND BUTLER, W. H. (1985) A quantitative study of stage specific spermatocyte damage following administration of ethylene glycol monomethyl ether in the rat. Experimental Molecular Pathology, 43, 321-336.
2. DRAPER, R. AND TIMBRELL, J. A. (1996) Urinary creatine as a potential marker of testicular damage. Effect of vasectomy. Reproductive Toxicology, in press.
3. FOSTER, P. M. D., CREASY, D. M., FOSTER, J. R., THOMAS, L. C., COOK, M. W. AND GANGOLLI, S. D. (1983) Testicular toxicity of ethylene glycol monomethyl and monoethyl ethers in the rat. Toxicology and Applied Pharmacology, 69, 385-399.
4. GRAY, J., NICHOLSON, J. K., CREASY, D. M. AND TIMBRELL, J. A. (1990) Studies on the relationship between acute testicular damage and urinary plasma creatine concentration. Archives of Toxicology, 64, 443-450.
5. LEE, H. J., FILLERS, W. S. AND IYENGAR, M. R. (1988) Phosphocreatine, an intracellular high-energy compound, is found in the extracellular fluid of the seminal vesicles in mice and rats. Proceedings of National Academy of Sciences, 85, 7265-7269.
6. LEE, H., GONG, C., WU, S. AND IYENGAR, M. R. (1991) Accumulation of phosphocreatine and creatine in the cells and fluid of mouse seminal vesicles is regulated by testosterone. Biology of Reproduction, 44, 540-545.
7. MOORE, N. P., CREASY, D. M., GRAY, T. J. B. AND TIMBRELL, J. A. (1992) Urinary creatine profiles after administration of cell specific testicular toxicants to the rat. Archives of Toxicology, 66, 435-442.
8. MOSS, E. J., THOMAS, L. V., COOK, M. W., WALTERS, D. G., FOSTER, P. M. D., CREASY, D. M. AND GRAY, T. M. B. (1985) The role of metabolism in 2-methoxyethanol-induced testicular toxicity. Toxicology and Applied Pharmacology, 79, 480-489.
9. 1H-NMR urinalysis studies on the biochemical effects of cadmium in the rat. Molecular Pharmacology, 36, 398-404.
10. NAHAS, K., LE NET, J-L., PROVOST, J. P. AND TOMASZEWSKI, K. E. (1993) An investigation of urinary creatine excretion as a potential marker for testicular damage. Human and Experimental Toxicology, 12, 173-176.
11. RAWCLIFFE, L., CREASY, D. AND TIMBRELL, J. A. (1989) Urinary creatine as a possible marker for testicular damage: studies with the testicular toxic com pound 2-methoxyethanol. Reproductive Toxicology, 3, 269-274.
12. READER, S. C. J., SHINGLES, C. AND STONARD, M. D. (1991) Acute testicular toxicity of 1,3-dinitrobenzene and ethylene glycol monomethyl ether in the rat: evaluation of biochemical effect markers and hormonal responses. Fundamental Applied Toxicology, 16, 61-70.
13. RUSSELL, L. D., ETTLIN, R. A., SINHA HIKIM, A. P. AND CLEGG, E. D. (1990) Histological and Histopathotogical Evaluation of the Testis (Florida: Cache River Press).
14. SEIDEL, J., MOLLERING, H. AND ZIEGENHORN, J. (1984) Sensitive color reagent for the enzymatic determination of creatine. Journal Clinical Chemistry, 30, 968-969.
15. TIMBRELL, J. A., DRAPER, R. AND WATERFIELD, C. J. (1994) Biomarkers in Toxicology. New uses for some old molecules? Toxicology and Ecotoxicology News, 1, 4-14.
16. TRAINA, M. E., FAZZI, P., URBANI, E. AND MANTOVANI, A. (1995) Is urinary creatine a marker of testicular toxicity in mice? Paper presented at the 2nd IFCC/Arnold Beckman European Conference on Biomarkers in Environmental Toxicology, Cannes, June 1995, Abstract B7, p. 79.
17. WARD, J. A., ROBINSON, J. AND MORRIS, I. D. (1989) Strain-dependency of procarbazine-induced testicular toxicity. Reproductive Toxicology, 3, 43-50.