Conformational Analysis. 50. C-Methyl-1,2,3,4-tetrahydroisoquinolines

Journal of Organic Chemistry

Volumn 62, Issue 26, 1997, Pages 9154-9158

  Olefirowicz, Edward M ^a,b   Eliel, Ernest L ^a  

^a University of North Carolina at Chapel Hill   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0004999568     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo971257r     Document Type: Article

References (34)

1. Hesse, M. Alkaloid Chemistry; Wiley: New York, 1981, pp 32-43. Shamma, M. The Isoquinoline Alkaloids; Academic Press: New York, 1972, Chapters 1 and 2. Bentley, K. W. The Isoquinoline Alkaloids; Pergamon: New York, 1965. Bringmann, G.; Pokorny, F. In The Alkaloids; ed. G. A., Cordell, Ed.; Vol. 46, Academic Press: 1995; Chapter 4.
2. Hesse, M. Alkaloid Chemistry; Wiley: New York, 1981, pp 32-43. Shamma, M. The Isoquinoline Alkaloids; Academic Press: New York, 1972, Chapters 1 and 2. Bentley, K. W. The Isoquinoline Alkaloids; Pergamon: New York, 1965. Bringmann, G.; Pokorny, F. In The Alkaloids; ed. G. A., Cordell, Ed.; Vol. 46, Academic Press: 1995; Chapter 4.
3. Hesse, M. Alkaloid Chemistry; Wiley: New York, 1981, pp 32-43. Shamma, M. The Isoquinoline Alkaloids; Academic Press: New York, 1972, Chapters 1 and 2. Bentley, K. W. The Isoquinoline Alkaloids; Pergamon: New York, 1965. Bringmann, G.; Pokorny, F. In The Alkaloids; ed. G. A., Cordell, Ed.; Vol. 46, Academic Press: 1995; Chapter 4.
4. Hesse, M. Alkaloid Chemistry; Wiley: New York, 1981, pp 32-43. Shamma, M. The Isoquinoline Alkaloids; Academic Press: New York, 1972, Chapters 1 and 2. Bentley, K. W. The Isoquinoline Alkaloids; Pergamon: New York, 1965. Bringmann, G.; Pokorny, F. In The Alkaloids; ed. G. A., Cordell, Ed.; Vol. 46, Academic Press: 1995; Chapter 4.
5. Cf. Chem. Eng. News 1997, March 10, 13. The compound is an N-methyltransferase inhibitor: (Grunewald, G. L.; Sall, D. J.; Monn, J. A. J. Med. Chem. 1988, 31, 824-830) and is also used as a synthetic α-amino acid in synthetic peptides; e.g., Wilkes, B. C.; Schiller, P. W. Biopolymers 1994, 34, 1213-1219.
6. Cf. Chem. Eng. News 1997, March 10, 13. The compound is an N-methyltransferase inhibitor: (Grunewald, G. L.; Sall, D. J.; Monn, J. A. J. Med. Chem. 1988, 31, 824-830) and is also used as a synthetic α-amino acid in synthetic peptides; e.g., Wilkes, B. C.; Schiller, P. W. Biopolymers 1994, 34, 1213-1219.
7. Cf. Chem. Eng. News 1997, March 10, 13. The compound is an N-methyltransferase inhibitor: (Grunewald, G. L.; Sall, D. J.; Monn, J. A. J. Med. Chem. 1988, 31, 824-830) and is also used as a synthetic α-amino acid in synthetic peptides; e.g., Wilkes, B. C.; Schiller, P. W. Biopolymers 1994, 34, 1213-1219.
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18. The earliest application of this method we could find is by LaBlanche-Combier, A.; Levisalles, J.; Pete, J.-P.; Rudler, H. Bull. Soc. Chim. Fr. 1963, 1689-1701. See also: Eliel, E. L.; Wilen, S, H. Stereochemistry of Organic Compounds; Wiley: New York 1994; pp 641.
19. The earliest application of this method we could find is by LaBlanche-Combier, A.; Levisalles, J.; Pete, J.-P.; Rudler, H. Bull. Soc. Chim. Fr. 1963, 1689-1701. See also: Eliel, E. L.; Wilen, S, H. Stereochemistry of Organic Compounds; Wiley: New York 1994; pp 641.
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24. Eliel, E. L.; Knoeber, M. C. J. Am. Chem. Soc. 1968, 90, 3444-3458.
25. -1.
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