Radiation biology and treatment options in radiation oncology

Cancer Research

Volumn 59, Issue 7 SUPPL., 1999, Pages

  Withers, H Rodney ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER RADIOTHERAPY; CELL CYCLE; CONFERENCE PAPER; GROWTH ACCELERATION; HUMAN; MATHEMATICAL ANALYSIS; ONCOLOGY; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RADIOBIOLOGY; RADIOSENSITIVITY; TUMOR GROWTH;

ANIMALS; CELL CYCLE; CELL DIVISION; DOSE FRACTIONATION; HUMANS; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; RADIOBIOLOGY; RADIOTHERAPY;

EID: 0004900753     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (70)

1. Regaud, C. La radiosenibilite des neoplasms melins dans ses relations avec la fluctuation de la multiplication cellulaire. C. R. Soc. Biol., 86: 933-995, 1922.
2. Schwarz, G. Merkwurdige schwankungen der rontgenemfindlichkeit bei einem und demselben patienten. Wien. Med. Wochenschr., 52: 2597-2598, 1914.
3. Puck, T. T., and Marcus, P. I. Action of X-rays on mammalian cells. J. Exp. Med., 103: 653-666, 1956.
4. Elkind, M. M., and Sutton, H. X-ray damage and recovery in mammalian cells in culture. Nature (Lond.), 184: 1293-1295, 1959.
5. Hewitt, H. B., and Wilson, C. W. A survival curve for mammalian leukemia cells irradiated in vivo. Br. J. Cancer, 13: 69-75, 1959.
6. Till, J. E., and McCulloch, A. E. Repair processes in irradiated mouse hematopoietic tissue. Ann. N. Y. Acad. Sci., 114: 115-125, 1964.
7. Withers, H. R. The dose-survival relationship for irradiation of epithelial cells of mouse skin. Br. J. Radiol., 40: 187-194, 1967.
8. Kember, N. F. Cell survival and radiation damage in growth cartilage. Br. J. Radiol., 40: 496-505, 1967.
9. Potten, C. S., and Hendry, J. H. Cell Clones: Manual of Mammalian Cell Techniques. Edinburgh: Churchill-Livingstone, 1985.
10. Fowler, J. F., and Stern, B. E. Dose time relationships in radiotherapy and the validity of cell survival curve models. Br. J. Radiol., 36: 335-443, 1963.
11. Suit, H. D., and Shalek, R. J. Response of spontaneous mammary carcinoma of the C3H mouse to X-irradiation given under conditions of local tissue anoxia. J. Natl. Cancer Inst. (Bethesda), 31: 497-509, 1963.
12. Kallman, R. F. Rodent Tumor Models in Experimental Cancer Therapy. New York: Pergamon, 1987.
13. Hermens, A. F., and Barendsen, G. W. Changes of cell proliferation characteristics in a rat rhabdomyosarcoma before and after X-irradiation. Eur. J. Cancer, 5: 173-189, 1969.
14. Withers, H. R. The 4 R's of radiotherapy. In: J. T. Lett and H. Alder (eds.), Advances in Radiation Biology, Vol. 5, pp. 241-271. New York: Academic Press, 1975.
15. Brown, J. M., and Giaccia, A. J. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res., 58: 1408-1416, 1998.
16. Terasima, T., and Tolmach, L. J. Variation in several responses of HeLa cells to X-irradiation during the division cycle. Biophys. J., 31: 11-33, 1963.
17. Elkind, M. M., and Sinclair, W. K. Recovery in X-irradiated mammalian cells. In: M. Ebert and A. Howard (eds.), Current Topics in Radiation Research, Vol. 1, pp. 165-220. Amsterdam: North Holland Publishing Co., 1965.
18. Sinclair, W. K. Cyclic X-ray responses in mammalian cells in vitro. Radiat. Res., 33: 620-643, 1968.
19. Whitmore, G. F., Gulyas, S., and Botond, J. Radiation sensitivity throughout the cell cycle and its relation to recovery. In: R. Shalek and H. D. Suit (eds.), Cellular Radiation Biology (Symposium), pp. 423-429. Baltimore: Williams and Wilkins, 1965.
20. Withers, H. R., Mason, K., Reid, B. O., Dubravsky, N., Barkley, H. T., Jr., Brown, B. W., and Smathers, J. B. Response of mouse intestine to neutrons and gamma rays in relation to dose fractionation and division cycle. Cancer (Phila.), 34: 39-47, 1974.
21. Withers, H. R. Cell cycle redistribution as a factor in multifraction irradiation. Radiology, 114: 199-202, 1975.
22. Strandqvist, M. Studien uber die kumulative Wirkung der Rontgenstrahlen bei Fraktionierung. Acta Radiol., 55 (Suppl. 1): 1-293, 1944.
23. Ellis, F. Dose, time and fractionation: a clinical hypothesis. Clin. Radiol., 20:1-7, 1969.
24. Withers, H. R. Isoeffect curves for various proliferative tissues in experimental animals. In: W. L. Caldwell and D. D. Tolbert (eds.), Proceedings of the Conference on Time Dose Relationships in Clinical Radiotherapy, pp. 30-38. Madison, WI: Madison Printing and Publishing, 1975.
25. Thames, H. D., Jr., Withers, H. R., Peters, L. J., and Fletcher, G. H. Changes in early and late radiation responses with altered dose fractionation: implications for dose survival relationships. Int. J. Radiat. Oncol. Biol. Phys., 8: 219-226, 1982.
26. Withers, H. R., Thames, H. D., Jr., Peters, L. J., and Fletcher, G. H. Normal tissue radioresistance in clinical radiotherapy. In: G. H. Fletcher, C. Nervi, and H. R. Withers (eds.), Biological Bases and Clinical Implications of Tumor Radioresistance, pp. 139-152. New York: Masson, 1983.
27. Ang, K. K., Thames, H. D., and Peters, L. J. Altered fractionation schedules. In: C. A. Perez and L. W. Brady (eds.), Principles and Practice of Radiation Oncology, Ed. 3, pp. 119-142. New York: J. P. Lippincott-Raven, 1997.
28. Brenner, D., and Hall, E. Fractionation and protraction for radiotherapy of prostate carcinoma. Int. J. Radiat. Oncol. Biol. Phys., in press, 1999.
29. Fowler, J. F. Fractionation and therapeutic gain. In: G. G. Steel, G. E. Adams, and A. Horwich (eds.), The Biological Bases of Radiotherapy, pp. 181-207. Amsterdam: Elsevier, 1989.
30. Thames, H. D., Jr., Bentzen, S. M., Turreson, I., Overgaard, M., and van den Bogaert, W. Time-dose factors in radiotherapy: a review of the human data. Radiother. Oncol., 19: 219-235, 1990.
31. Withers, H. R., and McBride, W. H. Biologic basis of radiation therapy. In: C. A. Perez and L. W. Brady (eds.), Principles and Practice of Radiation Oncology, Ed. 3, pp. 79-118. New York: J. P. Lippincott-Raven, 1997.
32. Withers, H. R., Peters, L. J., Taylor, J. M. G., Owen, J. B., Morrison, W. H., Schultheiss, T. E., Keane, T., O'Sullivan, B., van Dyk, J., Gupta, N., Wang, C. C., Jones, C. U., Doppke, K. P., Myint S., Thompson, M., Parsons, J. T., Mendenhall, W. M., Dische, S., Aird, E. G. A., Henk, J. M., Bidmean, M. A. M., Svoboda, V., Chon, Y., Hanlon, A. L., Peters, T. L., and Hanks, G. E. Local control of carcinoma of the tonsil by radiation therapy: an analysis of patterns of fractionation in nine institutions. Int. J. Radiat. Oncol. Biol. Phys., 33: 549-562, 1995.
33. Taylor, J. M. G., Withers, H. R., and Hu, Z. A comparison of mathematical models for regeneration in acutely responding tissues. Int. J. Radiat. Oncol. Biol. Phys., 15: 1389-1400, 1988.
34. Tucker, S. L., Thames, H. D., Brown, B. W., Mason, K. A., Hunter, N. R., and Withers, H. R. Direct analysis of in vivo colony survival after single and fractionated doses of radiation. Int. J. Radiat. Biol., 59: 777-795, 1991.
35. Field, S. B., Morris, C., Denekamp, J., and Fowler, J. F. The response of mouse skin to fractionation X-rays. Eur. J. Cancer, 11: 291-299, 1975.
36. Withers, H. R., Thames, H. D., Jr., and Peters, L. J. Biological bases for high RBE values for late effects of neutron irradiation. Int. J. Radiat. Oncol. Biol. Phys., 8: 2071-2076, 1982.
37. Meistrich, M. L., Hunter, N., Suzuki, N., Trostle, P. K., and Withers, H. R. Gradual regeneration of mouse testicular stem cells after exposure to ionizing radiation. Radiat. Res., 74: 349-362, 1978.
38. Withers, H. R., Hunter, N., Barkley, H. T., Jr., and Reid, B. O. Radiation survival and regeneration characteristics of spermatogenic stem cells of mouse testis. Radiat. Res., 57: 88-103, 1974.
39. Littbrand, B., and Revesz, L. The effect of oxygen on cellular survival and recovery after radiation. Br. J. Radiol., 42: 914-920, 1969.
40. Stuschke, M., and Thames, H. D. Hyperfractionated radiotherapy and human tumors: overview of the randomized clinical trials. Int. J. Radiat. Oncol. Biol. Phys., 37: 259-267, 1997.
41. Horiot, J. C., LeFur, R., Nguyen, T., Chenal, C., Schraub, S., Alfonsi, S., Gardani, G., van den Bogaert, W., Danczak, S., Bolla, M., van Glabbeke, M., and dePauw, M. Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy. Radiother, Oncol., 25: 231-241, 1992.
42. Withers, H. R., Peters, L. J., Taylor, J. M. G., Owen, J. B., Morrison, W. H., Schultheiss, T. E., Keane, T., O'Sullivan, B., van Dyk, J., Gupta, N., Wang, C. C., Jones, C. U., Doppke, K. P., Myint S., Thompson, M., Parsons, J. T., Mendenhall, W. M., Dische, S., Aird, E. G. A., Henk, J. M., Bidmean, M. A. M., Svoboda, V., Chon, Y., Hanlon, A. L., Peters, T. L., and Hanks, G. E. Late normal tissue sequelae from radiation therapy for carcinoma of the tonsil: patterns of fractionation study of radiobiology. Int. J. Radiat. Oncol. Biol. Phys., 33: 563-568, 1995.
43. Thames, H. D., and Suit, H. D. Tumor radioresponsiveness versus fractionation sensitivity. Int. J. Radiat. Oncol. Biol. Phys., 12: 687-693, 1986.
44. Saunders, M., Dische, S., and Grosch, E. J. Experience with CHART. Int. J. Radiat. Oncol. Biol. Phys., 21: 871-877, 1991.
45. Steel, G. G. Growth Kinetics of Tumors. Oxford: Oxford University Press, 1977.
46. Tubiana, M. L. H. Gray Medal Lecture. Cell kinetics and radiation oncology. Int. J. Radiat. Oncol. Biol. Phys., 8: 1471-1489, 1982.
47. Dische, S., Saunders, M. C., Barrett, A., Harvey, A., Gibson, D., and Parmar, M. A randomized multicentre trial of CHART versus conventional radiotherapy in head and neck cancer. Radiother. Oncol., 44: 123-136, 1997.
48. Maciejewski, B., Preuss-Bayer, G., and Trott, K. R. The influence of the number of fractions and of overall treatment time on local control and late complications rate in squamous cell carcinoma of the larynx. Int. J. Radiat. Oncol. Biol. Phys., 9: 321-328, 1983.
49. Maciejewski, B., Withers, H. R., Taylor, J. M. G., and Hliniak, A. Dose fractionation and regeneration in radiotherapy for cancer of the oral cavity and oropharynx. Part 1. Tumor dose response and regeneration. Int. J. Radiat. Oncol. Biol. Phys., 16: 831-843, 1989.
50. Overgaard, J., Hjelm-Hansen, M., Johanssen, L. V., and Andersen, A. P. Comparison of conventional and split-course radiotherapy as primary treatment in carcinoma of the larynx. Acta Oncol., 27: 147-152, 1988.
51. Peters, L. J., Ang, K. K., and Thames, H. D. Accelerated fractionation in the treatment of head and neck cancer: a critical comparison of different strategies. Acta Oncol., 27: 185-194, 1988.
52. Roberts, S. A., Hendry, J. H., Brewster, A. E., and Slevin, N. J. The influence of radiotherapy treatment time on the control of laryngeal cancer: a direct analysis of data from two British Institute of Radiotherapy trials to calculate the lag period and the time factor. Br. J. Radiol., 67: 790-794, 1994.
53. Slevin, N. J., Hendry, J. H., Roberts, S. A., and Agren-Cronqvist, A. The effect of increasing the treatment time beyond three weeks on the control of T2 and T3 laryngeal cancer using radiotherapy. Radiother. Oncol., 24: 215-220, 1992.
54. Withers, H. R., Taylor, J. M. G., and Maciejewski, B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol., 27: 131-146, 1988.
55. Withers, H. R. Treatment-induced accelerated human tumor growth. Semin. Radiat. Oncol. 3: 135-143, 1993.
56. Keane, T. J., Fyles, A., O'Sullivan, B., Barton, M., Maki, E., and Simm, J. The effect of treatment duration on local control of squamous carcinoma of the tonsil and carcinoma of the cervix. Semin. Radiat. Oncol., 2: 26-28, 1992.
57. Robertson, C., Robertson, A. G., Hendry, J. H., Roberts, S. A., Slevin, N. J., Duncan, W. B., MacDougall, R. H., Kerr, G. R., O'Sullivan, B., and Keane, T. J. Similar decreases in local tumor control are calculated for treatment protraction and for interruptions in the radiotherapy of carcinoma of the larynx in four center. Int. J. Radiat. Oncol. Biol. Phys., 40: 319-329, 1998.
58. Barton, M. B., Keane, T. J., Gadalla, T., and Maki, E. The effect of treatment time and treatment interruption on tumor control following radical radiotherapy of laryngeal cancer. Radiother. Oncol., 23: 137-143, 1992.
59. Duncan, W., MacDougall, R. H., Kerr, G., and Downing, D. The adverse effects of treatment gaps in the outcome of radiotherapy for laryngeal cancer. Radiother. Oncol., 41: 203-207, 1996.
60. Fowler, J. F. The linear quadratic formula and progress in fractionated radiotherapy. Br. J. Radiol., 62: 679-685, 1989.
61. Fowler, J. F., and Lindstrom, M. J. Loss of local control with prolongation in radiotherapy. Int. J. Radiat. Oncol. Biol. Phys., 23: 457-467, 1992.
62. Fyles, A. W., Keane, T. J., Barton, M., and Simm, J. The effect of treatment duration in local control of cervix cancer. Radiother. Oncol., 25: 273-279, 1992.
63. Maciejewski, B., and Majewski, S. Dose fractionation and tumour repopulation in radiotherapy for bladder cancer. Radiother. Oncol., 21: 163-170, 1991.
64. Saunders, M., Dische, S., Barrett, A., Harvey, A., Gibson, D., and Parmar, M. Continuous hyperfractionated accelerated radiotherapy (CHART) in non-small cell lung cancer: a randomized multicentre trial. Lancet, 350: 161-165, 1997.
65. Lai, P. P., Pilepich, M. V., and Krall, J. M, Asbell, S. O., Hanks, G. E., Perez, C. A., Rubin, P., Sause, W. T., and Cox, J. D. The effect of overall treatment time on the outcome of definitive radiotherapy for localized prostate carcinoma: the Radiation Therapy Oncology Group 75-06 and 77-06 experience. Int. J. Radiat. Oncol. Biol. Phys., 21: 925-933, 1991.
66. Amdur, R. J., Parsons, J. T., Fitzgerald, L. T., and Million, R. R. The effect of overall treatment time on local control in patients with adenocarcinoma of the prostate treated with radiation therapy. Int. J. Radiat. Oncol. Biol. Phys., 19: 1377-1382, 1990.
67. Roberts, S. A., and Hendry, J. H. The delay before onset of accelerated tumor cell repopulation during radiotherapy: a direct maximum likelihood analysis of a collection of world-wide tumour control data. Radiother. Oncol., 29: 69-74, 1993.
68. Peters, L. J., and Withers, H. R. Applying radiobiological principles to combined modality treatment of head and neck cancer: the time factor. Int. J. Radiat. Oncol. Biol. Phys., 39: 831-836, 1997.
69. Jain, R. Barriers to drug delivery in solid tumors. Sci. Am., 271: 58-65, 1994.
70. El-Sayed, S., and Nelson, N. Adjuvant and adjunctive chemotherapy in the management of squamous cell carcinoma of the head and neck region. A meta-analysis of prospective and randomised trials. J. Clin. Oncol., 14: 838-847, 1996.