메뉴 건너뛰기




Volumn 130, Issue 4, 1997, Pages 521-528

Highly substituted cyclams: Stereoselective synthesis and coordination properties

Author keywords

Cyclam, binding constant; Hydrog nation; Macrocycles; N ligands

Indexed keywords


EID: 0004574998     PISSN: 00092940     EISSN: None     Source Type: Journal    
DOI: 10.1002/cber.19971300412     Document Type: Article
Times cited : (7)

References (51)
  • 19
    • 0000974850 scopus 로고
    • The design of receptor units for carboxylates and phosphates is of much interest since they serve as anchoring sites for numerous biological substrates.
    • [9al M. W. Hosseini, A. J. Blacker, J.-M. Lehn, J. Am. Chem. Soc. 1990, 772, 3896-3904. The design of receptor units for carboxylates and phosphates is of much interest since they serve as anchoring sites for numerous biological substrates.
    • (1990) J. Am. Chem. Soc. , vol.772 , pp. 3896-3904
    • Hosseini, M.W.1    Blacker, A.J.2    Lehn, J.-M.3
  • 23
    • 0006414594 scopus 로고
    • For reviews and procedures, see: [11a] B. E. Douglas (Ed.), Inorganic Synthesen 1978, 75, 1-52.
    • (1978) Inorganic Synthesen , vol.75 , pp. 1-52
    • Douglas, B.E.1
  • 24
    • 33745338294 scopus 로고
    • Thieme, Stuttgart
    • [11b] J L. F. Tietze, Th. Eicher, Reaktionen und Synthese, 2nd. Ed., Thieme, Stuttgart, 1991, p. 375.
    • (1991) Reaktionen Und Synthese, 2nd. Ed. , pp. 375
  • 27
    • 33745413150 scopus 로고    scopus 로고
    • [12a] B König pelka H Zieg p Q JoneSj J Dix Chem Commun. 1996, 471-472.
    • (1996) Chem Commun. , pp. 471-472
  • 29
    • 33745402527 scopus 로고    scopus 로고
    • note
    • Small amounts of mono- and of trisubstituted products were detected in the reaction mixtures by HPLC. The isomeric disubstituted products could not be separated by column chromatography. The use of more than 2 equiv. of BuLi and electrophile still yields a reaction mixture with isomeric disubstituted compounds as the major producs. However, substantial amounts of trisubstituted and small amounts of mono- and tetrasubstituted products were also detected.
  • 31
    • 33745364451 scopus 로고    scopus 로고
    • The less clean Raney nickel hydrogénations of disubstituted compounds require longer reaction times and higher temperatures.
    • [15) The less clean Raney nickel hydrogénations of disubstituted compounds require longer reaction times and higher temperatures.
  • 34
    • 33745392063 scopus 로고    scopus 로고
    • Deprotonation with MeLi and treatment with Mel gave an N,N,N,N-tetramethylated derivative (2a-Me) of 2a.
    • [16d] Deprotonation with MeLi and treatment with Mel gave an N,N,N,N-tetramethylated derivative (2a-Me) of 2a.
  • 35
    • 85088241877 scopus 로고    scopus 로고
    • 2 see réf. [12]
    • 2 see réf. [12]
  • 36
    • 33745401105 scopus 로고    scopus 로고
    • note
    • [17b] Crystallographic data (excluding structure factors) for the structures reported in this paper have been deposited with the Cambridge Crystallographic Data Centre. Copies of the data can be obtained free of charge on application to The Director, CCDC, 12 Union Road, Cambridge CB2 1EZ, UK (fax: int. code +(1223) 336-033, e-mail: deposit@chemcrys.cam.ac.uk), on quoting the depository number CCDC-100090.
  • 37
    • 33745332323 scopus 로고    scopus 로고
    • For cyclam metal complexes with square-planar coordination geometry, see
    • For cyclam metal complexes with square-planar coordination geometry, see:
  • 39
    • 33845550087 scopus 로고
    • 2: A. \V. Addison, E. Sinn, Inorg. Chem. 1983, 22, 1225-1228.
    • (1983) Inorg. Chem. , vol.22 , pp. 1225-1228
    • Sinn, E.1
  • 41
    • 33745392064 scopus 로고    scopus 로고
    • Cyclam and cyclam complexes give well-resolved NMR spectra at room temperature.
    • Cyclam and cyclam complexes give well-resolved NMR spectra at room temperature.
  • 44
    • 33745398217 scopus 로고    scopus 로고
    • Ag/AgCl in LiCl-saturated ethanol was used as reference electrode. Potential vs. NHE: 143 mV.
    • Ag/AgCl in LiCl-saturated ethanol was used as reference electrode. Potential vs. NHE: 143 mV.
  • 45
    • 33745409039 scopus 로고
    • - I23bl K. A. Connors, Binding Constants, Wiiey, New York, 1987.
    • [23a] A E Marten, R. j. Motekaitis, Stability Constants, 2nd. Ed., VCH, New York, 1992. - I23bl K. A. Connors, Binding Constants, Wiiey, New York, 1987.
    • (1992) Stability Constants, 2nd. Ed., VCH, New York
  • 46
    • 33745367915 scopus 로고    scopus 로고
    • The kinetics of complex formation are currently under investigation.
    • [24) The kinetics of complex formation are currently under investigation.
  • 50
    • 85088252519 scopus 로고    scopus 로고
    • a value of the imido proton of uridine under these conditions was determined as 11.91(3).
    • a value of the imido proton of uridine under these conditions was determined as 11.91(3).
  • 51
    • 0000497576 scopus 로고
    • 4) with Zn-OCIO3 of 238 pm. T. A. Tyson, K. O. Hodgson, B. Hedman, G. R. Clark, Acta Cryst. (C) 1990, 46, 1638.
    • (1990) Acta Cryst. (C) , vol.46 , pp. 1638


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.