Complexity and performance of on-chip biochemical assays

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 2978, Issue , 1997, Pages 172-179

  Kopf Sill, Anne R ^a   Nikiforov, Theo ^a   Bousse, Luc J ^a   Nagle, Rob ^a   Parce, J W ^a  

^a Caliper Life Sciences   (United States)

Author keywords

Biochemical assay; Competitive binding assay; Dilution series; Fraction collection; Microchip

Indexed keywords

ASSAYS; BINDING SITES; MECHANICAL ENGINEERING; MECHANICS; MECHATRONICS; MICROPROCESSOR CHIPS;

BIOCHEMICAL ASSAY; COMPETITIVE BINDING ASSAY; DILUTION SERIES; FRACTION COLLECTION; MICROCHIP;

INTEGRATED CIRCUITS;

EID: 0003686794     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.269974     Document Type: Conference Paper

References (11)

1. D.J. Harrison, A. Manz, Z. Fan, H. Ludi, H. M. Widmer, "Capillary electrophoresis and sample injection systems integrated on a planar glass chip," Anal. Chem., 64 (1992) 1926-1932.
2. D.J. Harrison, K.Fluri, K. Seiler, Z. Fan, C. S. Effenhauser, A. Manz, "Micromachining a miniaturized capillary electrophoresis-based chemical analysis system on a chip," Science, 261, pp. 895-897, 1993.
3. S.C. Jacobson et al., "Effects of injection schemes and column geometry on the performance of microchip electrophoresis devices," Anal. Chem., 66 , pp. 1107-1113, 1994.
4. S.C. Jacobson, R. Hergenröder, L. B. Koutny, J.M. Ramsey, "High-speed separations on a microchip," Anal. Chem., 66 , pp. 1114-1118, 1994.
5. S.C. Jacobson and J.M. Ramsey, "Integrated microdevice for DNA restiction fragment analysis," Anal. Chem., 68 , pp. 720-723, 1996.
6. L.B. Koutny, D. Schmalzing, T.A. Taylor, M. Fuchs, "Microchip electrophoretic immunoassay for serum cortisol," Anal. Chem. , 68, pp. 18-22, 1996.
7. A.T. Woolley and R.A. Matthies, "Ultra-high-speed DNA fragment separations using microfabricated capillary array electrophoresis chips," Proc. Natl. Acad. Sci. USA, 91, pp. 11348-11352, 1994.
8. A.T. Woolley and R.A. Matthies, "Ultra-high-speed DNA sequencing using capillary electrophoresis chips," Anal. Chem., 67 , pp. 3676-3680, 1995.
9. S.C. Jacobson, R. Hergenröder, A. W. Moore, Jr., J.M. Ramsey, "Precolumn reactions with electrophoretic analysis integrated on a microchip," Anal. Chem., 66 , pp. 4127-4123, 1994.
10. J. M. Ramsey, S. C. Jacobson, M.R. Knapp, "Microfabricated chemical measurement systems," Nature Med., 1 (10), pp. 1093-1096, 1995.
11. S. Hjerten, "High-performance electrophoresis: elimination of electroendoosmosis and solute adsorption," J.Chromatogr., 347, pp. 191-198, 1985.