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Volumn 2, Issue 4, 1996, Pages 258-267

Preclinical and clinical pharmacology of efegatran (LY294468): A novel antithrombin for the treatment of acute coronary syndromes

Author keywords

Efegatran; Myocardial infarction; Thrombin inhibitor; Thrombosis; Unstable angina

Indexed keywords


EID: 0003308863     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/107602969600200406     Document Type: Article
Times cited : (16)

References (30)
  • 1
    • 0018932163 scopus 로고
    • Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction
    • DeWood MA, Spores J, Notske R, et al. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med 1980;65:897.
    • (1980) N Engl J Med , vol.65 , pp. 897
    • DeWood, M.A.1    Spores, J.2    Notske, R.3
  • 2
    • 0027123107 scopus 로고
    • Molecular and cellular biology of blood coagulation
    • Furie B, Furie BC. Molecular and cellular biology of blood coagulation. N Engl J Med 1992;326:800.
    • (1992) N Engl J Med , vol.326 , pp. 800
    • Furie, B.1    Furie, B.C.2
  • 3
    • 0023754429 scopus 로고
    • Aspirin, heparin, or both to treat acute unstable angina
    • Théroux P, Ouimet H, McCans J, et al. Aspirin, heparin, or both to treat acute unstable angina. N Engl J Med 1988;319: 1105.
    • (1988) N Engl J Med , vol.319 , pp. 1105
    • Théroux, P.1    Ouimet, H.2    McCans, J.3
  • 4
    • 0026584571 scopus 로고
    • Thrombolytic therapy: Reocclusion rates with adjunctive aspirin and its relation to heparin therapy
    • Sherry S, Marder VJ. Thrombolytic therapy: reocclusion rates with adjunctive aspirin and its relation to heparin therapy. J Am Coll Cardiol 1992;19:678.
    • (1992) J Am Coll Cardiol , vol.19 , pp. 678
    • Sherry, S.1    Marder, V.J.2
  • 5
    • 0026017841 scopus 로고
    • Antiplatelet and antithrombotic therapy in unstable angina
    • Théroux P. Antiplatelet and antithrombotic therapy in unstable angina. Am J Cardiol 1991;68:92B.
    • (1991) Am J Cardiol , vol.68
    • Théroux, P.1
  • 6
    • 0026541425 scopus 로고
    • Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: A meta-analysis
    • Roux S, Christeller S, Lüdin E. Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: a meta-analysis. J Am Coll Cardiol 1992;19:671.
    • (1992) J Am Coll Cardiol , vol.19 , pp. 671
    • Roux, S.1    Christeller, S.2    Lüdin, E.3
  • 7
    • 0025875792 scopus 로고
    • Anticoagulant and antithrombotic actions of recombinant hirudin
    • Kaiser B. Anticoagulant and antithrombotic actions of recombinant hirudin. Thromb Haemost 1991;17:130.
    • (1991) Thromb Haemost , vol.17 , pp. 130
    • Kaiser, B.1
  • 8
    • 0025563384 scopus 로고
    • Hirudin, heparin, and placebo during deep arterial injury in the pig
    • Heras M, Chesebro JH, Webster MWI, et al. Hirudin, heparin, and placebo during deep arterial injury in the pig. Circulation 1990;82:1476.
    • (1990) Circulation , vol.82 , pp. 1476
    • Heras, M.1    Chesebro, J.H.2    Webster, M.W.I.3
  • 9
    • 0026558347 scopus 로고
    • Conjunctive enhancement of enzymatic thrombolysis and prevention of thrombotic reocclusion with selective factor Xa inhibitor, tick anticoagulant peptide: Comparison to hirudin and heparin in a canine model of acute coronary artery thrombosis
    • Sitko GR, Ramjit DR, Stabilito II, et al. Conjunctive enhancement of enzymatic thrombolysis and prevention of thrombotic reocclusion with selective factor Xa inhibitor, tick anticoagulant peptide: comparison to hirudin and heparin in a canine model of acute coronary artery thrombosis. Circulation 1992;85:805.
    • (1992) Circulation , vol.85 , pp. 805
    • Sitko, G.R.1    Ramjit, D.R.2    Stabilito, I.I.3
  • 11
    • 0028037517 scopus 로고
    • Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes
    • Topol EJ. Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. Circulation 1994;90:1631.
    • (1994) Circulation , vol.90 , pp. 1631
    • Topol, E.J.1
  • 12
    • 0028092111 scopus 로고
    • Hirudin in acute myocardial infarction: Safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A trial
    • Antman ET. Hirudin in acute myocardial infarction: safety report from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction (TIMI) 9A trial. Circulation 1994;90: 1624.
    • (1994) Circulation , vol.90 , pp. 1624
    • Antman, E.T.1
  • 13
    • 0028117846 scopus 로고
    • Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT III) study
    • Neuhaus K-L, Essen RV, Tebbe U, et al. Safety observations from the pilot phase of the randomized r-Hirudin for Improvement of Thrombolysis (HIT III) study. Circulation 1994;90:1638.
    • (1994) Circulation , vol.90 , pp. 1638
    • Neuhaus, K.-L.1    Essen, R.V.2    Tebbe, U.3
  • 14
    • 24044541071 scopus 로고
    • Hirulog™ vs. heparin during percutaneous transluminal coronary angioplasty in patients with post-infarction angina: Results of the myocardial infarction arm of the hirulog angioplasty trial
    • Strony J, Bittl JA, Deutsch E, et al. Hirulog™ vs. heparin during percutaneous transluminal coronary angioplasty in patients with post-infarction angina: results of the myocardial infarction arm of the hirulog angioplasty trial [Abstract]. J Am Coll Cardiol 1995;25:357A.
    • (1995) J Am Coll Cardiol , vol.25
    • Strony, J.1    Bittl, J.A.2    Deutsch, E.3
  • 15
    • 0006133114 scopus 로고
    • Anticoagulant properties of efegatran, a direct thrombin inhibitor in patients with unstable angina
    • Simoons ML, van Mittenburg A, Scheffer MG, et al. Anticoagulant properties of efegatran, a direct thrombin inhibitor in patients with unstable angina. Eur Heart J 1994;15:120.
    • (1994) Eur Heart J , vol.15 , pp. 120
    • Simoons, M.L.1    Van Mittenburg, A.2    Scheffer, M.G.3
  • 16
    • 0026651846 scopus 로고
    • Pharmacological assessment of the antithrombotic activity of the peptide thrombin inhibitor, D-methyl-phenylalanyl-prolyl-arginal (GYKI-14766), in a canine model of coronary artery thrombosis
    • Jackson CV, Crowe VG, Frank JD, et al. Pharmacological assessment of the antithrombotic activity of the peptide thrombin inhibitor, D-methyl-phenylalanyl-prolyl-arginal (GYKI-14766), in a canine model of coronary artery thrombosis. J Pharmacol Exp Ther 1992;261:546.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 546
    • Jackson, C.V.1    Crowe, V.G.2    Frank, J.D.3
  • 17
    • 0021164010 scopus 로고
    • International committee communications: Measurement of the bleeding time
    • Mielke CH. International committee communications: measurement of the bleeding time. Thromb Haemost 1984;52: 210.
    • (1984) Thromb Haemost , vol.52 , pp. 210
    • Mielke, C.H.1
  • 18
    • 0025328906 scopus 로고
    • Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H
    • Bajusz S, Szell E, Badgy D, et al. Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H. J Med Chem 1990;33:1729.
    • (1990) J Med Chem , vol.33 , pp. 1729
    • Bajusz, S.1    Szell, E.2    Badgy, D.3
  • 20
    • 8944231643 scopus 로고    scopus 로고
    • A family of arginal thrombin inhibitors related to efegatran
    • Smith GF, Shuman RT, Craft TJ, et al. A family of arginal thrombin inhibitors related to efegatran. Thromb Haemost 1996;22:173-83.
    • (1996) Thromb Haemost , vol.22 , pp. 173-183
    • Smith, G.F.1    Shuman, R.T.2    Craft, T.J.3
  • 21
    • 0027409404 scopus 로고
    • A player of many parts: The spotlight falls on thrombin's structure
    • Stubbs MT, Bodde W. A player of many parts: the spotlight falls on thrombin's structure. Thromb Res 1993;69:1.
    • (1993) Thromb Res , vol.69 , pp. 1
    • Stubbs, M.T.1    Bodde, W.2
  • 23
    • 0027407160 scopus 로고
    • Reversible tripeptide thrombin inhibitors as adjunctive agents to coronary thrombolysis: A comparison with heparin in a canine model of coronary artery thrombosis
    • Jackson CV, Wilson HC, Crowe VG, et al. Reversible tripeptide thrombin inhibitors as adjunctive agents to coronary thrombolysis: a comparison with heparin in a canine model of coronary artery thrombosis. J Cardiovasc Pharmacol 1993;21:587.
    • (1993) J Cardiovasc Pharmacol , vol.21 , pp. 587
    • Jackson, C.V.1    Wilson, H.C.2    Crowe, V.G.3
  • 24
    • 0028296374 scopus 로고
    • A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) 5 trial
    • Cannon CP, McCabe CH, Henry TD, et al. A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 5 trial. J Am Coll Cardiol 1994;23:993.
    • (1994) J Am Coll Cardiol , vol.23 , pp. 993
    • Cannon, C.P.1    McCabe, C.H.2    Henry, T.D.3
  • 25
    • 0028795568 scopus 로고
    • Initial experience with hirudin and streptokinase in acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) 6 trial
    • Lee L, and the TIMI 6 Investigators. Initial experience with hirudin and streptokinase in acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 6 trial. Am J Cardiol 1995;75:7.
    • (1995) Am J Cardiol , vol.75 , pp. 7
    • Lee, L.1
  • 26
    • 0028936602 scopus 로고
    • Randomized double-blind comparison of two doses of hirulog with heparin as adjunctive therapy to streptokinase to promote early patency of the infarct-related artery in acute myocardial infarction
    • Théroux P, Pérez-Villa F, Waters D, et al. Randomized double-blind comparison of two doses of hirulog with heparin as adjunctive therapy to streptokinase to promote early patency of the infarct-related artery in acute myocardial infarction. Circulation 1995;91:2132.
    • (1995) Circulation , vol.91 , pp. 2132
    • Théroux, P.1    Pérez-Villa, F.2    Waters, D.3
  • 27
    • 0027207766 scopus 로고
    • Maintenance of patency after thrombolysis in stenotic coronary arteries requires combined inhibition of thrombin and platelets
    • Prager NA, Torr-Brown SR, Sobel BE, et al. Maintenance of patency after thrombolysis in stenotic coronary arteries requires combined inhibition of thrombin and platelets. J Am Coll Cardiol 1993;22:296.
    • (1993) J Am Coll Cardiol , vol.22 , pp. 296
    • Prager, N.A.1    Torr-Brown, S.R.2    Sobel, B.E.3
  • 28
    • 0025143892 scopus 로고
    • Comparative effects of aspirin, a synthetic thrombin inhibitor and a monoclonal antiplatelet glycoprotein IIb/IIIa antibody on coronary artery reperfusion, reocclusion and bleeding with recombinant tissue-type plasminogen activator in a canine preparation
    • Yasuda T, Gold HK, Yaoita H, et al. Comparative effects of aspirin, a synthetic thrombin inhibitor and a monoclonal antiplatelet glycoprotein IIb/IIIa antibody on coronary artery reperfusion, reocclusion and bleeding with recombinant tissue-type plasminogen activator in a canine preparation. J Am Coll Cardiol 1990;16:714.
    • (1990) J Am Coll Cardiol , vol.16 , pp. 714
    • Yasuda, T.1    Gold, H.K.2    Yaoita, H.3
  • 29
    • 0027953552 scopus 로고
    • Prevention of rethrombosis after coronary thrombolysis in a chronic canine model. II. Adjunctive therapy with r-hirudin
    • Rote W, Mu D-X, Bates E, et al. Prevention of rethrombosis after coronary thrombolysis in a chronic canine model. II. Adjunctive therapy with r-hirudin. J Cardiovasc Pharmacol 1994;23:203.
    • (1994) J Cardiovasc Pharmacol , vol.23 , pp. 203
    • Rote, W.1    Mu, D.-X.2    Bates, E.3
  • 30
    • 0027361488 scopus 로고
    • Recombinant hirudin in patients with chronic, stable coronary artery disease: Safety, half-life, and effect on coagulation parameters
    • Zoldhelyi P, Webster MWI, Fuster V, et al. Recombinant hirudin in patients with chronic, stable coronary artery disease: safety, half-life, and effect on coagulation parameters. Circulation 1993;88:2015.
    • (1993) Circulation , vol.88 , pp. 2015
    • Zoldhelyi, P.1    Webster, M.W.I.2    Fuster, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.