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Volumn 133, Issue 1-3, 2001, Pages 130-132

Approaches to random mutagenesis with cytochrome P450 and glutathione transferase enzymes

Author keywords

Cytochrome P450; Diaholalkane activation; Glutathione transferase; Random mutagenesis

Indexed keywords


EID: 0003290545     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (1)

References (9)
  • 1
    • 0030220851 scopus 로고    scopus 로고
    • Engineering new functions and altering existing functions
    • Z. Shao, F.H. Arnold, Engineering new functions and altering existing functions, Curr. Opin. Struct. Biol. 6 (1996) 513-518.
    • (1996) Curr. Opin. Struct. Biol. , vol.6 , pp. 513-518
    • Shao, Z.1    Arnold, F.H.2
  • 2
    • 0033608962 scopus 로고    scopus 로고
    • Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties
    • A. Parikh, P.D. Josephy, F.P. Guengerich, Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties, Biochemistry 38 (1999) 5283-5289.
    • (1999) Biochemistry , vol.38 , pp. 5283-5289
    • Parikh, A.1    Josephy, P.D.2    Guengerich, F.P.3
  • 3
    • 0029159746 scopus 로고
    • Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme
    • A.M. Gulick, W.E. Fahl, Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme, Proc. Natl. Acad. Sci. USA 92 (1995) 8140-8144.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8140-8144
    • Gulick, A.M.1    Fahl, W.E.2
  • 4
    • 0029008514 scopus 로고
    • Glutathione transferases with novel active sites isolated by phage display from a library of random mutants
    • M. Widersten, B. Mannervik, Glutathione transferases with novel active sites isolated by phage display from a library of random mutants, J. Mol. Biol. 250 (1995) 115-122.
    • (1995) J. Mol. Biol. , vol.250 , pp. 115-122
    • Widersten, M.1    Mannervik, B.2
  • 5
    • 0008252723 scopus 로고
    • 7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of 1,2-dibromoethane to DNA
    • 7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of 1,2-dibromoethane to DNA, Proc. Natl. Acad. Sci. USA 80 (1983) 5266-5270.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 5266-5270
    • Ozawa, N.1    Guengerich, F.P.2
  • 6
    • 0027321555 scopus 로고
    • Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes
    • R. Thier, S.E. Pemble, J.B. Taylor, W.G. Humphreys, M. Persmark, B. Ketterer, P.P. Guengerich, Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes, Proc. Natl. Acad. Sci. USA 90 (1993) 8576-8580.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8576-8580
    • Thier, R.1    Pemble, S.E.2    Taylor, J.B.3    Humphreys, W.G.4    Persmark, M.5    Ketterer, B.6    Guengerich, P.P.7
  • 7
    • 0030070661 scopus 로고    scopus 로고
    • Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004
    • T. Shimada, H. Yamazaki, Y. Oda, A. Hiratsuka, T. Watabe, F.P. Guengerich, Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004, Chem. Res. Toxicol. 9 (1996) 333-340.
    • (1996) Chem. Res. Toxicol. , vol.9 , pp. 333-340
    • Shimada, T.1    Yamazaki, H.2    Oda, Y.3    Hiratsuka, A.4    Watabe, T.5    Guengerich, F.P.6
  • 8
    • 0025268190 scopus 로고
    • Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes
    • J.L. Cmarik, P.B. Inskeep, D.J. Meyer, M.J. Meredith, B. Ketterer, P.P. Guengerich, Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes, Cancer Res. 50 (1990) 2747-2752.
    • (1990) Cancer Res. , vol.50 , pp. 2747-2752
    • Cmarik, J.L.1    Inskeep, P.B.2    Meyer, D.J.3    Meredith, M.J.4    Ketterer, B.5    Guengerich, P.P.6
  • 9
    • 0029003807 scopus 로고
    • Crystal structure of a θ-class glutathione transferase
    • M.C.J. Wilce, P.G. Board, S.C. Feil, M.W. Parker, Crystal structure of a θ-class glutathione transferase, EMBO J. 14 (1995) 2133-2143.
    • (1995) EMBO J. , vol.14 , pp. 2133-2143
    • Wilce, M.C.J.1    Board, P.G.2    Feil, S.C.3    Parker, M.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.