Evaluation of possible active site residues in GSTZ 1-1

Chemico-Biological Interactions

Volumn 133, Issue 1-3, 2001, Pages 185-187

  Coggan, M ^a   Liu, D ^a   Chelvanayagam, G ^a   Anderson, W B ^b   Anders, M W ^b   Board, P G ^a  

^a Australian National University   (Australia)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Dichloroacetic acid; Glutathione transferase zeta; Mutagenesis

Indexed keywords

EID: 0003206680     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. P.G. Board, R.T. Baker, G. Chelvanayagam, L.S. Jermiin, Zeta, a novel class of glutathione transferases in a range of species from plants to humans, Biochem. J. 328 (1997) 929-935.
2. J.M. Fernandez-Canon, M.A. Penalva, Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue, J. Biol. Chem. 273 (1998) 329-337.
3. Z. Tong, P.G. Board, M.W. Anders, Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids, Chem. Res. Toxicol. 11 (1998) 1332-1338.
4. A.B. DeAngelo, F.B. Daniel, B.M. Most, G.R. Olson, The carcinogenicity of dichloroacetic acid in the male Fischer 344 rat, Toxicology 114 (1996) 207-221.
5. P.W. Stacpoole, The pharmacology of dichloroacetate, Metabolism 38 (1989) 1124-1144.
6. A.C. Blackburn, H.F. Tzeng, M.W. Anders, P.G. Board, Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis, Pharmacogenetics 10 (2000) 49-57.
7. H.-F. Tzeng, A.C. Blackburn, P.G. Board, M.W. Anders, Polymorphism-and species-dependent inactivation of glutathione transferase zeta by dichloroacetate. Chem. Res. Toxicol. (2000), in press.