Analysis of the effects of chitosan on inflammation, angiogenesis, fibroplasia, and collagen deposition in polyvinyl alcohol sponge implants in rat wounds

Wound Repair and Regeneration

Volumn 4, Issue 1, 1996, Pages 48-52

  Diegelmann, Robert F ^a,c   Dunn, James D ^a   Lindblad, William J ^b   Cohen, I Kelman ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c MCV Box 980117   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0003189526     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-475X.1996.40109.x     Document Type: Article

References (12)

1. Diegelmann RF, Cohen IK, McCoy B J. Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro. J Cell Physiol 1979;98:341-5.
2. Lazarus GS, Cooper DM, Knighton DR, Margolis DJ, Percoraro RE, Rodeheaver G, Robson MC. Definitions and guidelines for assessment of wounds and evaluation of healing. WOUND REP REG 1994;2:165-70.
3. Toole BP. Glycosaminoglycans in morphogenesis. In: Hay ED, editor. Cell biology of extracellular matrix. New York: Plenum Press, 1981:259-93.
4. Weitzhandler M, Bernfield MR. Proteoglycan glycoconjugates. In: Cohen IK, Diegelmann RF, Lindblad WJ, editors. Wound healing: biochemical and clinical aspects. Philadelphia: Saunders, 1992:195-208.
5. Diegelmann RF, Lindblad WJ, Cohen IK. Measurement of collagen deposition following a standardized subcutaneous injury. Ann NY Acad Sci 1985;460:419-21.
6. Diegelmann RF, Lindblad WJ, Cohen IK. A subcutaneous implant for wound healing studies in humans. J Surg Res 1986;40:229-37.
7. Malette WG, Quigley HJ, Gaines RD, Johnson ND, Rainer WG. Chitosan: a new hemostatic. Ann Thorac Surg 1983;36:55-8.
8. Brandenburg G, Leibrock LG, Shuman R, Malette WG, Quigley H. Chitosan: a new topical hemostatic agent for diffuse capillary bleeding in brain tissue. Neurosurgery 1984;15:9-13.
9. Arand AG, Sawaya R. Intraoperative chemical hemostasis in neurosurgery. Neurosurgery 1986;18:223-33.
10. Klokkevold PR, Lew DS, Ellis DG, Bertolami CN. Effect of Chitosan on lingual hemostasis in rabbits. J Oral Maxillofacial Surg 1991;49:858-63.
11. Bartone FF, Adickers ED. Chitosan: effects on wound healing in urogenital tissue: preliminary report. J Urol 1988;140:1134-7.
12. Chung LY, Schmidt RJ, Hamlyn PF, Sagar BF, Andrews AM, Turner TD. Biocompatibility of potential wound management products: fungal mycelia as a source of chitin/Chitosan and the effect on the proliferation of human F1000 fibroblasts in culture. J Biomed Mater Res 1994;28:463-9.