Use of the N-in-1 approach for rapid pharmacokinetic screening of drug candidates using LC-MS-MS

American Laboratory

Volumn 30, Issue 24, 1998, Pages 11-14

  Liang, Li ^a   Chi, Cecilia ^a   Wright, Matthew ^b   Timby, Dani ^a   Unger, Steve ^a  

^a DUPONT COMPANY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0003042380     PISSN: 00447749     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (9)

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3. Olah TV, McLoughlin DA, Gilbert JD. The simultaneous determination of mixtures of drug candidates by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry as an in vivo drug screening procedure. Rap Commun Mass Spectrom 1997; 11:17-23.
4. Havel C, Cass R, Der K, et al. Rapid screening of protease inhibitors for potential oral bioavailability. American Society for Mass Spectrometry. Proc 45th Annual Conference on Mass Spectrometry and Allied Topics, 1997:695.
5. Korfmacher WA, Bryant MS, Veals J, Cox KA, Ng K, Lin C-C. Strategies for high throughput assays using HPLC-atmospheric pressure ionization-MS/MS in new drug discovery applications. American Society for Mass Spectrometry. Proc 45th Annual Conference on Mass Spectrometry and Allied Topics. 1997:698.
6. Dobson RLM, Quijano M, Coombs MA, Neubecker TA, Dowty ME, Dietsch CR. Bioavailability estimates for multiple polar compounds: N-in-1 dosing and HPLC/MS/MS analysis of rat urine. American Society for Mass Spectrometry. Proc 45th Annual Conference on Mass Spectrometry and Allied Topics, 1997:703.
7. Wolf FE, Bader TR, Bomes DM, et al. Preclinical pharmacokinetic screening using N-in-1 dosing and LC/ISP/MS/MS analysis. American Society for Mass Spectrometry. Proc 45th Annual Conference on Mass Spectrometry and Allied Topics, 1997:1300.
8. Richards D, Cussans N, Henry B, Nuttal J. Simultaneous MRM analysis of multiple drug mixtures in high electrolyte buffers by LC/MS/MS for cell transport studies. American Society for Mass Spectrometry. Proc 45th Annual Conference on Mass Spectrometry and Allied Topics, 1997:1314.
9. Allen MC, Shah TS, Day WW. Rapid determination of oral pharmacokinetics and plasma free fraction using cocktail approaches: methods and application. Pharm Res 1998; 15(1):93-7.