Disposition of propofol after medetomidine premedication in beagle dogs

Veterinary Anaesthesia and Analgesia

Volumn 24, Issue 1, 1997, Pages 23-29

  Hall, L W ^a   Lagerweij, E ^b   Nolan, A M ^c   Sear, J W ^d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0003026583     PISSN: 14672987     EISSN: 14672995     Source Type: Journal    
DOI: 10.1111/j.1467-2995.1997.tb00264.x     Document Type: Article

References (28)

1. Barash, P.G., Kay, H., Tinker, J. and Geha, A.S. (1981) Rate pressure product: A reliable index of myocardial oxygen consumption. Anesthesiol. 55, A37.
2. Benet, L.Z. and Galeazzi, RX. (1979) Non-compartmentai determination of the steady state volume of distribution. J. Pharm. Sci. 68: 1071–1078.
3. Bloor, B.C., Frankland, M., Alper, G., Raybould, D., Weitz & Shurtliff, M. (1992) Hemodynamic and and sedative effects of dexmedetomidine in dogs. J. Pharmacol. Exp. Therap. 263, 610–697.
4. Campbell, G.A., Morgan, D.J. and Kumar, K. (1988) Extended blood collection period required to define distribution and elimination kinetics of propofol. Brit. J. Clin. Pharmacol. 26, 187–190.
5. Cullen, L.K. and Reynoldson, J.A. (1993) Xylazine or medetomidine premedication before propofol anaesthesia. Vet. Rec. 132, 378–383.
6. Fonda, D. (1991) Continuous infusion anaesthesia with propofol in dogs: Clinically optimized dosages. Proc. 4th Int. Congr. Vet. Anaesth. Utrecht, pp. 159–161.
7. Hall, L.W. and Chambers, J.P. (1987) A clinical trial of propofol infusion anaesthesia in dogs. J. small Anim. Pract. 28, 623–637.
8. Hall, L.W., Lagerweij, E., Nolan, A.M. and Sear, J.W. (1994) The effect of medetomidine on the pharmacokinetics of propofol in dogs. Am. J. vet. Res. 55, 116–120.
9. Hamlin, R.L. and Bednarski, L.S. (1989) Studies to determine the optimal dose of medetomidine for the dog. Acta vet. scand. 85, 89–95.
10. Kanto, J. and Gepts, E. (1989) Pharmacokinetic implications for the clinical use of propofol. Clin. Pharmac. 17, 308–326.
11. Keegan, R.D. and Greene, S.A. (1993) Cardiovascular effect of a continuous two hour propofol infusion in dogs. Comparison with isoflurane anaesthesia. Vet. Surg. 22, 537–543.
12. Lagerweij, E., Hall, L.W. and Nolan, A.M. (1993) Effects of medetomidine premedication on propofol infusion anaesthesia in dogs. J. vet. Anaesth. 20, 78–81.
13. Naeije, R., Lejune, P., Leeman, M., Melot, C. and Deloof, T. (1989) Effects of propofol on pulmonary and systemic arterial pressure-flow relationships in hyperoxic and hypoxic dogs. Brit. J. Anaesth. 62, 532–539.
14. Nolan, A.M. and Reid, J. (1993) Pharmacokinetics of propofol administered by infusion in dogs undergoing surgery. Br. J. Anaesth. 70, 546–551.
15. Park, W.K., Lynch, C. and Johns, R.A. (1992) Effects of propofol and thiopental in isolated rat aorta and pulmonary artery. Anesthesiol. 77, 956–963.
16. Plummer, G.F. (1987) Improved method for the determination of propofol in blood by high performance liquid chromatography with fluorescence detection. J. Chromatog. 421, 171–176.
17. Reens, N., Hellebrekers, L.J. and Sap, R. (1993) Medetomidine as a premedicant for ketamine or propofol anaesthesaia in dogs. Tijdschrift voor diergeneeskunde, 118, Suppl. 1 668.
18. Robertson, S.A., Johnson, S. and Beemsterboer, J. (1992) Cardiopulmonary, anesthetic, and postanesthetic effects of intravenous infusions of propofol in Greyhounds and non-Greyhounds. Am. J. vet. Res. 53, 1027–1032.
19. Rouby, J.J., Andreev, A., Leger, P., Arthuad, M., Landault, C., Vicaut, E., Maistre, G., Eurin, J., Gandjbakch, I. and Viars, P. (1991) Peripheral vascular effects of thiopental and propofol in humans with artificial hearts. Anesthesiol. 75, 32–42.
20. Ruffolo, R.R. (1985) Distribution and function of peripheral a-adrenoceptors in the cardiovascular system. Pharmacology, Biochemistry and Behaviour 22, 827–832.
21. 2—adrenoceptors. J. Autonom. Pharmacol. 5, 275–284.
22. Savola, J.M. (1989) Cardiovascular actions of medetomidine and their reversal by atipamezole. Acta vet. scand. 85 Suppl, 39–47.
23. Sear, J.W., Diedericks, J. and Foex, P. (1994) Continuous infusions of propofol administered to dogs: Effects on ICG and propofol disposition. Br. J. Anaesth. 72, 451–455.
24. Sykes, M.K., Adams, A.P., Economedes, A., McCormick, P.W. and Munroe, J. (1970) The effect of variations in end-expiratory inflation pressure on cardio-respiratory function in normo-hypo-and hypervolaemic dogs. Br. J. Anaesth. 42, 669–677.
25. Uezono, S. and Clark, W.R. (1995) The effect of propofol on normal and increased pulmonary vascular resistance in isolated perfused rabbit lung. Anesthes. Analg. 80, 577–582.
26. Vainio, O. and Palmu, L. (1989) Cardiovascular and respiratory effects of medetomidine in dogs and influence of anticholinergics. Acta vet. scand. 30, 401–408.
27. Vainio, O. (1991) Propofol infusion anaesthesia in dogs premedicated with medetomidine. J. vet. Anaesth. 18, 35–37.
28. Zoran, D.L. and Riedesel, D.H. (1993) Pharmacokinetics of propofol in mixed breed dogs and greyhounds. Am. J. vet. Res, 54, 755–760.