Can we diagnose growth hormone deficiency?

Current Opinion in Endocrinology and Diabetes

Volumn 3, Issue 2, 1996, Pages 83-87

  Hunter, Maya K ^a   Rosenfeld, Ron G ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0002987677     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/00060793-199604000-00002     Document Type: Article

References (48)

1. Frasier D, Lippe B: Clinical review 11: the rational use of growth hormone during childhood. J Clin Endocrinol Metab 1990, 71:269-273.
2. Moran A, Brown D, Doherty L, Ainslie M, Sane K, Saxena K, Sheridan K, Spencer M, Sockalosky J, Ternand C: Diagnosis, monitoring, and treatment of short stature in children: Twin Cities community standards. Endocrinologist 1995, 5:272-277. This nice review provides guidelines, primarily for the general practitioner, for approaching the child with short stature.
3. Cooney K, Pathak U, Watson A: Infant growth charts. Arch Dis Child 1995, 71:159-160.
4. Lanes R: Diagnostic limitations of spontaneous growth hormone measurements in normally growing prepubertal children. Am J Dis Child 1989, 143:1284-1286.
5. Rose S, Ross J, Uriarte M, Barnes K, Cassorla F, Cutler G: The advantage of measuring stimulated as compared with spontaneous growth hormone levels in the diagnosis of growth hormone deficiency. N Engl J Med 1988, 319:201-207.
6. Rose S, Municchi G, Barnes K, Kamp G, Uriarte M, Ross J, Cassorla F, Cutler G: Spontaneous growth hormone secretion increases during puberty in normal girls and boys. J Clin Endocrinol Metab 1991, 73:428-435.
7. Ho K, Evans W, Blizzard R, Veldhuis J, Merriam G, Samojlik E, Furlanetto R, Rogol A, Kaise D, Thorner M: Effects of sex and age on the 24-hour profile of growth hormone secretion in man: Importance of endogenous estradiol concentrations. J Clin Endocrinol Metab 1987, 64:51-58.
8. Shah A, Stanhope R, Matthew D: Hazards of pharmacological test of growth hormone secretion in childhood. BMJ 1992, 304:173-174.
9. Reiter E, Morris A, MacGillivray M, Weber D: Variable estimates of serum growth hormone concentrations by different radioassay systems. J Clin Endocrinol Metab 1988, 66:68-71.
10. Rosenfeld R, Albertsson-Wikland K, Cassorla F, Frasier S, Hasegawa Y, Hintz R, LaFranchi S, Lippe B, Loriaux L, Melmed S, Preece M, Ranke M, Reiter E, Rogol A, Underwood L, Werther G: Diagnostic controversy: the diagnosis of childhood growth hormone deficiency revisited. J Clin Endocrinol Metab 1995, 80:1532-1540. A comprehensive review of the current tests and procedures available to diagnose growth hormone deficiency. Limitations of these methods are addressed, with an emphasis on the assessment of the growth hormone-IGF axis as an alternative approach to diagnosing growth hormone deficiency.
11. Hindmarsh P, Swift P: An assessment of growth hormone provocation tests. Arch Dis Child 1995, 72:362-368. A nice review, including background and theory, of the more commonly used methods for assessing growth hormone release.
12. Mauras N, Blizzard R, Link K, Johnson M, Rogol A, Veldhuis J: Augmentation of growth hormone secretion during puberty: evidence for a pulse amplitude-modulated phenomenon. J Clin Endocrinol Metab 1987, 64:596-601.
13. Delter J, Boulis M, Harriss W, Hutsell T, Garcia J, Linfoot J: Growth hormone response patterns to sex hormone administration in growth retardation. Am J Med Sci 1970, 259:292-296.
14. Cacciari E, Tassoni P, Parisi G, Pirazzoli P, Zucchini S, Mandini M, Cicognani A, Balsamo A: Pitfalls in diagnosing impaired growth hormone (GH) secretion: retesting after replacement therapy of 63 patients defined as GH deficient. J Clin Endocrinol Metab 1992, 74:1284-1289.
15. Cacciari E, Tassoni P, Cicognani A, Pirazzoli P, Salardi S, Balsamo A, Cassio A, Zucchini S, Colli C, Tassinari D, Tani G, Gualandi S: Value and limits of pharmacological and physiological test to diagnose growth hormone (GH) deficiency and predict therapy response: first and second retesting during replacement therapy of patients defined as GH deficient. J Clin Endocrinol Metab 1994, 79:1663-1669.
16. Marin G, Domene H, Barnes K, Blackwell B, Cassorla F, Cutler G: The effects of estrogen priming and puberty on the growth hormone response to standardized treadmill exercise and arginine-insulin in normal girls and boys. J Clin Endocrinol Metab 1994, 79:537-541. The percentage of normal children who did not attain a growth hormone value greater than 7 μg/L declined from 61% at pubertal stage 1 to 0% at pubertal stages 4 and 5. Estrogen administration to prepubertal children significantly raised the peak growth hormone response. The false-positive tests for growth hormone deficiency in prepubertal subjects may reflect a prepubertal deficiency of sex steroids, rather than a disorder of growth hormone secretion.
17. Zadik Z, Chalew S, Gilula Z, Kowarski A: Reproducibility of growth hormone testing procedures: a comparison between 24-hour integrated concentration and pharmacological stimulation. J Clin Endocrinol Metab 1990, 71:1127-1130.
18. Hourd P, Edwards R: Current methods for the measurement of growth hormone in urine. Clin Endocrinol (Oxf) 1994, 40:155-170. A review of the current methods for measuring urinary growth hormone levels. Advantages and limitations are discussed, with the diagnostic value of urinary growth hormone in the assessment for growth hormone deficiency remaining unclear.
19. Baumann G, Abramson G: Urinary growth hormone in man: evidence for multiple molecular forms. J Clin Endocrinol Metab 1983, 56:305-311.
20. Ekins R: An overview of present and future ultrasensitive non-isotopic immunoassay development. Clin Biochem Rev 1987, 8:12-23.
21. Main K, Jarden M, Angelo L, Dinesen B, Hertel N, Juul A, Muller J, Skakkebaek N: The impact of gender and puberty on reference values for urinary growth hormone excretion: a study of 3 morning urine samples in 517 healthy children and adults. J Clin Endocrinol Metab 1994, 79:865-871. Reference values for urinary growth hormone are provided, after evaluating 517 healthy children and adults. Factors influencing urinary growth hormone excretion included sex, pubertal stage, urine volume, and collection period.
22. Pinnell S, Fox R, Krane S: Human collagens: differences in glycosylated hydroxylysines in skin and bone. Biochem Biophys Acta 1971, 229:119-122.
23. Rauch F, Schnabel D, Seibel M, Remer T, Stabrey A, Michalk D, Schonau E: Urinary excretion of galactosyl-hydroxylysine is a marker of growth in children. J Clin Endocrinol Metab 1995, 80:1295-1300.
24. Daughaday W, Rotwein P: Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid, and gene structures, serum and tissue concentrations. Endocr Rev 1989, 10:68-91.
25. Luna A, Wilson D, Wibbelsman C, Brown R, Nagashima R, Hintz R, Rosenfeld R: Somatomedins in adolescence: a cross-sectional study of the effect of puberty on plasma insulin-like growth factor I and II levels. J Clin Endocrinol Metab 1983, 57:268-271.
26. Rosenfield R, Furlanetto R, Bock D: Relationship of somatomedin-C concentrations to pubertal changes. J Pediatr 1983, 103:723-728.
27. Hesse V, Jahreis G, Schambach H, Vogel H, Vilser C, Seewald H, Borner A, Deichl A: Insulin-like growth factor I correlations to changes of the hormonal status in puberty and age. Exp Clin Endocrinol 1994, 102:289-298. Insulin-like growth factor-I values were correlated to multiple hormones during puberty and beyond. Increasing dehydroepiandrosterone sulfate levels were seen in pubertal boys, suggesting this as a positive stimulant of IGF-I synthesis.
28. Underwood L, D'Ercole A, Van Wyk JJ: Somatomedin-C and the assessment of growth. Pediatr Clin North Am 1980, 27:771-782.
29. Reiter E, Lovinger R: The use of commercially available somatomedin-C radioimmunoassay in patients with disorders of growth. J Pediatr 1981, 99:720-724.
30. Moore D, Ruvalcaba R, Smith E, Kelley V: Plasma somatomedin-C as a screening test for growth hormone deficiency in children and adolescents. Horm Res 1982, 16:49-55.
31. Juul A, Dalgaard P, Blum W, Bang P, Hall K, Michaelsen K, Muller J, Skakkebaek N: Serum levels of insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation. J Clin Endocrinol Metab 1995, 80:2534-2542. Normative data for IGFBP-3 concentrations and the various factors affecting those values are presented.
32. Blum W, Ranke M, Kietzmann K, Gauggel E, Zeisel H, Bierich J: A specific radioimmunoassay for the growth hormone (GH)-dependent somatomedin-binding protein: its use for diagnosis of GH deficiency. J Clin Endocrinol Metab 1990, 70:1292-1298.
33. Hasegawa Y, Hasegawa T, Aso T, Kotol S, Tsuchiya Y, Nose O, Ohyama Y, Araki K, Tanaka T, Saisyo S: Usefulness and limitation of measurement of insulin-like growth factor binding protein-3 (IGFBP-3) for diagnosis of growth hormone deficiency. Endocrinol Jpn 1992, 39:585-591.
34. Hasegawa Y, Hasegawa T, Aso T, Kotoh S, Nose O, Ohyama Y, Araki K, Tanaka T, Saisyo S, Yokoya S, Nishi Y, Miyamoto S, Sasaki N, Kurimoto F, Stene M, Tsuchiya Y: Clinical utility of insulin-like growth factor binding protein-3 in the evaluation and treatment of short children with suspected growth hormone deficiency. Eur J Endocrinol 1994, 131:27-32. Insulin-like growth factor-I and IGFBP-3 are shown to be useful for screening for complete growth hormone deficiency, but less so for partial growth hormone deficiency and normal short children. A pretreatment IGFBP-3 SD score of less than -1 suggested a favorable short-term response to growth hormone therapy.
35. Smith W, Nam T, Underwood L, Busby W, Celnicker A, Clemmons D: Use of insulin-like growth factor binding protein-2 (IGFBP-2), IGFBP-3, and IGF-I for assessing growth hormone status in short children. J Clin Endocrinol Metab 1993, 77:1294-1299.
36. Cianfarani S, Boemi S, Spagnoli A, Cappa M, Argiro G, Vaccaro F, Bitti M, Boscherini B: Is IGF binding protein-3 assessment helpful for the diagnosis of GH deficiency? Clin Endocrinol (Oxf) 1995, 43:43-47.
37. Hibi I, Tanaka T: Final height of patients with idlopathic growth hormone deficiency after long-term growth hormone treatment Acta Endocrinol (Copenh) 1989, 120:409-415.
38. Severi F: Final height in children with growth hormone deficiency. Horm Res 1995, 43:138-140.
39. Frisch H, Birnbacher R: Final height and pubertal development in children with growth hormone deficiency after long-term treatment. Horm Res 1995, 43:132-134.
40. Chipman J, Hicks J, Holcombe J, Draper M: Approaching final height in children treated for growth hormone deficiency. Horm Res 1995, 43:129-131.
41. Hochberg Z, Leiberman E, Landau H, Koren R, Zadik Z: Age as a determinant of the impact of growth hormone therapy on predicted adult height. Clin Endocrinol (Oxf) 1994, 41:331-335.
42. Bramswig J, Schlosser H, Kiese K: Final height in children with growth hormone deficiency. Horm Res 1995, 43:126-128.
43. Allen D, Brook C, Bridges N, Hindmarsh P, Guyda H, Frazier D: Therapeutic controversies: growth hormone (GH) treatment of non-GH deficient subjects. J Clin Endocrinol Metab 1994, 79:1239-1248. Several different views are offered in this article on the controversial subject of treating the non-growth-hormone-deficient child with growth hormone. Ethical and economic issues, clinical effectiveness, and safety are addressed.
44. McCaughey E, Mulligan J, Voss L, Betts P: Growth and metabolic consequences of growth hormone treatment in prepubertal short normal children. Arch Dis Child 1994, 71:201-206.
45. Loche S, Cambiaso P, Setzu S, Carta D, Marini R, Borrelli P, Cappa M: Final height after growth hormone therapy in non-growth hormone deficient children with short stature. J Pediatr 1994, 125:196-200.
46. Spagnoli A, Spadoni G, Cianfarani S, Pasquino A, Trolani S, Boscherini B: Prediction of the outcome of growth hormone therapy in children with idiopathic short stature. J Pediatr 1995, 126:905-909.
47. Goddard A, Covello R, Luoh S, Clackson T, Attie K, Gesundheit N, Rundle A, Wells J, Carlsson L: Mutations in the growth hormone receptor in children with Idiopathic short stature. N Engl J Med 1995, 333:1093-1098. Mutations in the region of the growth hormone receptor gene that codes for the extracellular domain of the receptor were found in four of 14 patients with idiopathic short stature. These children had normal growth hormone secretion, which suggests partial growth hormone insensitivity due to mutations in the growth hormone-receptor gene.
48. Binder G, Ranke M: Screening for growth hormone (GH) gene splice-site mutations in sporadic cases with severe isolated GH deficiency using ectopic transcript analysis. J Clin Endocrinol Metab 1995, 80:1247-1252.