Antagonism of paraoxon intoxication by recombinant phosphotriesterase encapsulated within sterically stabilized liposames

Toxicology and Applied Pharmacology

Volumn 156, Issue 1, 1999, Pages 56-63

  Petrikovics, I ^c   Hong, K ^a   Omburo, G ^c   Hu, Q Z ^c   Pei, L ^c   McGuinn, W D ^c   Sylvester, D ^c   Tamulinas, C ^c   Papahadjopoulos, D ^a   Jaszberenyi, J C ^b   Way, J L ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^c NONE

Author keywords

Long circulating liposomes; OPA anhydrase; Paraoxon antagonist; Paraoxon hydrolysis; Paraoxonase; Phosphotriesterase; Stealth liposomes; Sterically stabilized liposomes

Indexed keywords

4 NITROPHENOL; ANTIDOTE; ATROPINE; DYFLOS; LIPOSOME; PARAOXON; PARATHION; PRALIDOXIME; RECOMBINANT PHOSPHOTRIESTERASE; SARIN; SOMAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SPECIFICITY; ENZYME ISOLATION; ENZYME PURIFICATION; HYDROLYSIS; INTOXICATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; METABOLITE; MOUSE; NONHUMAN; TOXICOKINETICS;

ANIMALIA; ESCHERICHIA COLI; FLAVOBACTERIUM SP.;

EID: 0002978547     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8620     Document Type: Article

References (36)

1. Aldridge W. N. Serum esterase, an enzyme hydrolyzing diethylpA. Biochem. J. 53:1953;117-124.
2. Aldridge W. N., Hoskin F. C. G., Reiner E., Walker C. H. Suggestions for a nomenclature classification of enzymes hydrolysing organophosphorus compounds. Enzymes Hydrolysing Organophosphorus Compounds. 1989;Ellis Horwood, Chichester. p. 246-253.
3. Allen T. M. Long circulating (sterically stabilized) liposomes for targeted drug delivery. Adv. Drug Delivery Rev. 13:1994;285-309.
4. Ashani Y., Rothshild N., Segall Y., Levanon D., Raveh L. Prophylaxis against organophosphate poisoning by an enzyme hydrolyzing organophosphorous compound in mice. Life Sci. 49:1991;367-374.
5. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
6. Broomfield C. A. A purified recombinant phosphotriesterase protects mice against soman. Physiol. Toxicol. 70:1992;65-66.
7. Bruce D. R. An up-and-down method procedure for acute toxicity testing. Fundam. Appl. Toxicol. 5:1985;151-157.
8. Cannon E. P., Zitzer A. H., McGuinn W. D., Petrikovics I., Leung P., Way J. L. Antagonism of lethal effects of cyanide with rhodanese containing murine carrier erythrocytes. Proc. West. Pharmacol. Soc. 35:1992;187-190.
9. Cohen J. M., Warringa M. G. P. J. Purification and properties of dialkylfluorophosphatase. Biochem. Biophys. Acta. 26:1957;29-39.
10. DeLoach J. R., Harris R. L., Ihler G. M. An erythrocyte encapsulation dialyzer used in preparing large quantities of erythrocyte ghosts and encapsulation of pesticide in erythrocyte ghosts. Anal. Biochem. 102:1980;220-227.
11. Dixon W. J. The up-and-down method for small animal samples. Am. Stat. Assoc. J. 12:1965;967-978.
12. Dumas, D. P. 1989, The purification and characterization of the phosphotriesterase fromPseudomonas diminuta.
13. Dumas D. P., Durst H. D., Landis W. G., Raushel F. M., Wild J. R. Inactivation of the organophosphorus nerve agents by the phosphotriesterase fromPseudomonas diminuta. Arch. Biochem. Biophys. 277:1990;155-159.
14. Ihler G. M., Glew R. H., Schnure F. W. Enzyme loading erythrocytes. Proc. Natl. Acad. Sci. USA. 70:1973;2663-2666.
15. Kiss L., Gal S., Toth-Martinez B. L., Petrikovics I. Use of chromatofocusing for separation of beta-lactamases. J. Chromatogr. 262:1983;379-384.
16. Leung P., David W. D., Yao C. C., Cannon E. P., Way J. L. Rhodanese and sodium thiosulfate encapsulated in mouse carrier erythrocytes. Fundam. Appl. Toxicol. 16:1991;559-661.
17. Leung P., Ray L. E., Sander C., Way J. L. Encapsulation of thiosulfate cyanide sulfurtransferase by mouse erythrocytes. Toxicol. Appl. Pharmacol. 83:1986;101-102.
18. McDaniel C. S., Hopper L. L., Wild J. R. Cloning and sequencing of a plasmid-borne gene (opd) encoding a phosphotriesterase. J. Bacteriol. 170:1988;2306-2311.
19. McGuinn W. D., Baxter L., Pei L., Petrikovics I., Deloach J., Way J. L. Antagonism of the lethal effects of cyanide by a synthetic water soluble cobalt (III) porphyrin compound. Fundam. Appl. Toxicol. 23:1994;76-80.
20. Mounter L. A. Some studies of enzymatic effects of rabbit serum. J. Biochem. 209:1954;813-817.
21. Mulbry W. W., Karn J. S., Kearney C., Nelson J. O., McDaniel C. S., Wild J. R. Identification of a plasmid-borne parathion hydrolyze gene fromFlavobacterium sp.opdPseudomonas diminuta. Appl. Environ. Microbiol. 51:1986;926-930.
22. New R. R. C. Liposomes: A Practical Approach. 1990;Oxford University Press, New York.
23. Omburo G. A., Kuo J. M., Mullins L. S., Raushel F. M. Characterization of the zinc binding site of bacterial phosphotriesterase. J. Biol. Chem. 267:1992;13278-13283.
24. Papahadjopoulos D., Allen T. M., Gabizon A., Mayhew K., Matthay K., Huang S. K., Lee K. D., Woodle M. C., Lasic D. D., Redemann C., Martin F. J. Sterically stabilized liposomes: Improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc. Natl. Acad. Sci. USA. 88:1991;11460-11464.
25. Pei L., McGuinn W. D., Petrikovics I., Pu L., Cannon E. P., Way J. L. Determination of phosphotriesterase in blood. Toxicol. Methods. 4:1993;261-267.
26. Pei L., McGuinn W. D., Omburo G., Hawkins-Zitzer A., Petrikovics I., Cannon E. P., Way J. L. Spectrophotometric determination of paraoxonase within mouse carrier erythrocytes. Biochem. Appl. Biotechnol. 20:1994b;35-41.
27. Pei L., Omburo G., McGuinn W. D., Petrikovics I., Dave K., Raushel J. L., Wild J. R., DeLoach J. L., Way J. L. Encapsulation of phosphotriesterase within murine erythrocytes. Toxicol. Appl. Pharmacol. 124:1994a;296-301.
28. Pei L., Petrikovics I., Way J. L. Antagonism of the lethal effect of paraoxon by carrier erythrocytes containing organophosphorous acid anhydrase. Fundam. Appl. Toxicol. 28:1995;209-214.
29. Petrikovics I., Cannon E. P., McGuinn W. D., Way J. L. Cyanide antagonism with organic thiosulfonates and carrier red blood cells containing rhodanese. Fundam. Appl. Toxicol. 24:1995;1-8.
30. Petrikovics I., McGuinn W. D., Cannon E. P., Pei L., Way J. L. Encapsulation of rhodanese and organic thiosulfonates by mouse erythrocytes. Fundam. Appl. Toxicol. 23:1994;70-75.
31. Serdar C. M., Gibson D. T. Enzymatic hydrolysis of organophosphates: Cloning and expression of a parathion hydrolase gene fromPseudomonas diminuta. BioTechnology. 3:1985;567-571.
32. Serdar C. M., Gibson D. T., Munnecke D. M., Lancasrter J. H. Plasmid involvement in parathion hydrolysis byPseudomonas diminuta. Appl. Environ. Microbiol. 44:1982;246-249.
33. Serdar C. M., Murdock D. C., Rhode M. F. Parathion hydrolyse gene fromPseudomonas diminutaEscherichia coli. BioTechnology. 7:1989;1151-1155.
34. Way J. L., Leung P., Ray L., Sander C. Erythrocyte encapsulated thiosulfate sulfurtransferase. Bibl. Haematol. 51:1985;75-81.
35. Webb E. C. Recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology on the Nomenclature and Classification of Enzymes. 1992;Academic Press, San Diego.
36. Zech R., Zurcher K. Organophosphate splitting serum enzymes in different mammals. Comp. Biochem. Physiol. 48B:1974;427-433.