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0000309019
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Various polymer-supported heterogeneous catalysts have been used in dialkylzinc additions to aldehydes. For an overview see chapter II B in ref. 10 and Itsuno, S.; Sakurai, Y.; Ito, K.; Maruyama, T.; Nakahama, S.; Fréchet, J. M. J. J. Org. Chem. 1990, 55, 304.
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85033751852
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note
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3, THF (88%).
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42
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43
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85033749810
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note
-
The catalysis was performed as described in ref. 7 with a slight modification. Pure diethylzinc was used instead of a 1 M solution of the reagent in hexane. The ee was determined by HPLC using a chiral column. For retention times and conditions see ref. 7.
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44
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6044266630
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2 had to be used as column eluent after the standard product isolation with ether mixtures. This observation is in accord with reports of others describing unusual phenomena during the chromatography of large dendrimers. For example see ref. 5a and Xu, Z.; Kahr, M.; Walker, K. L.; Wilkins, C. L.; Moore, J. S. J. Am . Chem. Soc. 1994, 116, 4537.
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Oguni, N.; Matsuda, Y.; Kaneko, T. J. Am. Chem. Soc. 1988, 110, 7877. Bolm, C. In Advanced Asymmetric Synthesis: Stephenson, G. R., Ed.; Chapman & Hill: London, 1996.
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Stephenson, G. R., Ed.; Chapman & Hill: London
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Oguni, N.; Matsuda, Y.; Kaneko, T. J. Am. Chem. Soc. 1988, 110, 7877. Bolm, C. In Advanced Asymmetric Synthesis: Stephenson, G. R., Ed.; Chapman & Hill: London, 1996.
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Bolm, C.1
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47
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85033746301
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note
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The ee was determined by HPLC using a chiral column (Chiralcel OD).
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48
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85033737453
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in press. Dreisbach, C. PhD-thesis, University of Bonn
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49
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85033747345
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note
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3 Applications in two-phase and membrane reactors were proposed.
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