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All the aldehydes used in this study were made from the appropriate 6-deoxy-6-iodo carbohydrate derivative by treatment with activated zinc dust in ethanol. The original method as described by Vasella (ref. 12a) used the corresponding 6-bromo-6-deoxy compounds
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All the aldehydes used in this study were made from the appropriate 6-deoxy-6-iodo carbohydrate derivative by treatment with activated zinc dust in ethanol. The original method as described by Vasella (ref. 12a) used the corresponding 6-bromo-6-deoxy compounds.
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NOEs of similar magnitude were observed between such trans hydrogens in some of the other cycloadducts. For example, for bicycle 8, small NOEs were measured between H-6 and H-6a (H-6→ H-6a {3.9%}; H-6a→ H-6 {3.7%})
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NOEs of similar magnitude were observed between such trans hydrogens in some of the other cycloadducts. For example, for bicycle 8, small NOEs were measured between H-6 and H-6a (H-6→ H-6a {3.9%}; H-6a→ H-6 {3.7%}).
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29
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33747003038
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For a discussion and leading reference, see ref. 10a
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For a discussion and leading reference, see ref. 10a.
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