A Facile Preparation of Highly Substituted B-Ketoamides

Synthetic Communications

Volumn 19, Issue 1-2, 1989, Pages 59-62

  Lasley, Linda C ^a   Wright, Bradford B ^a  

^a 3M Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0002694903     PISSN: 00397911     EISSN: 15322432     Source Type: Journal    
DOI: 10.1080/00397918908050952     Document Type: Article

References (9)

1. For example, see Gates, P. A.; Dawson, E. A., Eur. Pat. 24,872, 11 Mar 1981.
2. For example, see DeShong, P., Lowmaster, N., E. Baralt, O. J. Org. Chma. 1983, AA, 1149; or Hishmat, O. H.; Gohar, A.-K.; Wassef, M. E.; Shalash, M. R.; Ismail, I. Pharm. Acta Helv. 1977, £2, 252.;
3. Reisch, J. Niemeyer, D. Tetrahedron Lett. 1968, 22, 3247.
4. Reisch, J.; Niemeyer, D. Tetrahedron 1971, 27, 4637.
5. Tirpak, R. E.; Olsen, R. S.; Rathke, M., W. J. Org. Chem. 1985, 50, 4877; Olsen, R. S.; Fataftah, Z. A.; Rathke, M. W. Svnth. Commun. 1986, lfi, 1133.
6. Based on representative yields of 50-75% for each alkylation an overall yield of 25-56% for two steps is calculated.
7. Zook, H. D.; Russo, T. J.; Ferrand, E. F.; Stotz, D. S., J. Ora. Chem. 1968, 22, 2222.
8. These products may result from a further reaction of an initially formed B-ketoamide.
9. Chadwich, D. H. and Cleveland, T. H. Kirk-Othmer Encyclopedia of Chemical Technology, Vol. 13, 3rd edn., Wiley, New York, 1981, 794.