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Volumn , Issue 22, 1999, Pages 3327-3331

Aryl H-phosphonates. Part 11. Synthetic and 31P NMR studies on the formation of aryl nucleoside H-phosphonates

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EID: 0002682724     PISSN: 0300922X     EISSN: None     Source Type: Journal    
DOI: 10.1039/a907150d     Document Type: Article
Times cited : (14)

References (28)
  • 14
    • 33746968973 scopus 로고    scopus 로고
    • note
    • Some less reactive aryl nucleoside H-phosphonates were isolated and characterized. See the Experimental section.
  • 19
    • 33747016058 scopus 로고    scopus 로고
    • note
    • In the reactions of 1 with 2c and 2d, no bispivaloyl phosphite 9 was present in the reaction mixtures and the major side products were those corresponding to diaryl phosphites 7 and aryl pivaloyl phosphites 8. For more acidic phenols, 2e-g, the amount of 9 increased along the series, and for a highly acidic pentachlorophenyl, it was the major reaction product (no formation of nucleoside pentachlorophenyl H-phosphonate was observed in this instance).
  • 20
    • 33747019350 scopus 로고    scopus 로고
    • note
    • In these reactions, the unreacted starting material 1 and the side products 7 + 8 + 9 amounted to 19% and 21% (for 2e), 40% and 34% (for 2f), 41% and 38% (for 2g), respectively (the composition of the reaction mixtures after ca. 5 min).
  • 26
    • 33747026512 scopus 로고    scopus 로고
    • note
    • The coupling promoted by rather unreactive chlorophosphate 5 (2.5 molar equiv.) was significantly slower, and was complete after ca. 5 h.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.