In vitro and in vivo activities of Melia azedarach L. aqueous leaf extracts on murine lymphocytes

Phytomedicine

Volumn 5, Issue 1, 1998, Pages 47-53

  Courreges M C ^a   Benencia, F ^a   Coulombie F C ^a   Coto, C E ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Immume system; Immunodulation; Leaf extracts; Melia azedarach L; Mouse

Indexed keywords

MELIA AZEDARACH; MURINAE;

EID: 0002664146     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0944-7113(98)80059-7     Document Type: Article

References (23)

1. Andrei, G. M., Coto, C. E. and de Torres, R. A.: Ensayos de actividad antiviral de extractos crudos y semipurificados de hojas verdes de Melia azedarach L. Rev. Arg. Microbiología 17: 187-194, 1985.
2. Andrei, G. M., Lampuri, J. S., Coto, C. E. and de Torres, R. A.: An antiviral factor from Melia azedarach prevents Tacaribe virus encephalitis in mice. Experientia 42: 843-845, 1986.
3. Andrei, G. M., Coulombié, F. C., Courrèges, M. C., de Torres, R. A. and Coto, C. E.: Meliacine, an antiviral compound from Melia azedarach L., inhibits interferon production. J. Interferon Res. 10: 469-475, 1990.
4. Benencia, F., Courrèges, M. C., Massouh, E. J. and Coulombié, F. C.: Effect of Melia azedarach L. leaf extracts on human complement and polymorphonuclear leukocytes. J. Ethnopharmacol. 41: 53-57, 1994.
5. Benencia, F., Courrèges, M. C., Nores, M. M. and Coulombié, F. C.: Immunomodulatory activities of Cedrela tubiflora leaf aqueous extracts. J. of Ethnopharmacol. 49: 133-139, 1995.
6. Benencia, F., Courrèges, M. C. and Coulombié, F. C.: In vitro activities of Cedrela tubiflora aqueous leaf extracts on murine macrophages, polymorphonuclear leukocytes and complement. Phytother. Res. 10: 37-41, 1996.
7. Benencia, F., Courrèges, M. C., Coulombié, F. C. and Coto, C. E.: Immunomodulatory activities of Melia azedarach leaf extracts on human monocytes. J. Herbs, Spices Med. Pl., 1997 (in press).
8. Bhakuni, D. S., Dhar, M. L., Dhar, M. M., Dhawan, B. W. and Mehrotra, B. N.: Screening of plants for biological activity. Part II. Indian J. Exp. I. Biol. 7: 250-262, 1969.
9. Bray, D. H., Warhurst, D. C., Connolly, J. D., O'Neill, M. J. and Phillipson, J. D.: Plants as sources of antimalarial drugs. Part 7. Activity of some species of Meliaceae plants and their constituent limonoids. Phytother. Res. 4: 29-34, 1990.
10. Claus, J. D., Coto, C. E. and de Torres, R. A.: Natural resistance of BALB/C mice to Herpes Simplex virus type 1 intraperitoneal infection is abrogated by a plant extract with in vitro and herpes activity. Phytother. Res., 1998 (in press).
11. Coulombié, F. C., Andrei, G. M., Laguens, R. P., de Torres, R. A. and Coto, C. E.: Partially purified leaf extracts of Melia azedarach L. inhibit Tacaribe virus growth in neonatal mice. Phytother. Res. 6: 15-19, 1992.
12. Courrèges, M. C., Benencia, F., Coto, C. E., Massouh, E. J. and Coulombié, F. C.: In vitro antiphagocytic effect of Melia azedarach leaf extracts on mouse peritoneal exudate cells. J. Ethnopharmacol. 43: 135-140, 1994.
13. Cunninghan, A. J. and Szenberg, A.: Further improvements in the plaque technique for detecting single antibody forming cells. Immunology 14: 599-603, 1968.
14. Ford, W. L., Burr, W. and Simonsen, M.: A lymph node weight assay for the graft versus host activity of rat lymphoid cells. Transplantation 10: 258-260, 1970.
15. Fujiwara, T., Takeda, T., Ogihara, Y., Shimizu, M., Nomura, T. and Tomita, T.: Studies of the structure of polysaccharides from the bark of Melia azadirachta. Chem. Pharm. Bull. 30: 4025-4030, 1982.
16. Labadie, R. P., Van der Nat, J. M., Simons, J. M., Kroes, B. H., Kosasi, S., Van der Berg, A. J. J., t'Hart, L. A., Van der Sluis, S., Abeysekera, A., Bamunuarachi, A. and de Silva, K. T. D.: An ethnopharmacognostic approach to the search of immunomodulators of plant origin. Planta Med. 55: 339 -348, 1989.
17. Nores, M. M., Courrèges, M. C., Benencia, F. and Coulombié, F. C.: Immunomodulatory activities of Cedrela lilloi and Trichilia elegans aqueous leaf extracts. J. Ethnopharmacol. 55: 99-106, 1997.
18. Patel, N.G.: Indians traditional medicine: Ayurveda. In: R. P. Steiner (Ed.), Folk Medicine: the Art and Science. American Chemical Society, Washington D.C., USA, p. 57, 1986.
19. Smith, K.: T cell growth factor. Immunol. Rev. 51: 337-357, 1980.
20. Van der Nat, J. M., Klerx, J. P. A. M., Van Dijk, H., de Silva, K. T. D. and Labadie, R.P.: Immunomodulatory activity of an aqueous extract of Azadirachta indica stem bark. J. Ethnopharmacol. 19: 125-131, 1987.
21. Wachsman, M. S., Andrei, G. M., Daelli, M. G., Coto, C. E. and de Torres, R. A.: Actividad antiviral asociada a una fracción polipeptídica obtenida de extractos de Melia azedarach L. Acta Farmacol. Bonaerense 3: 27-31, 1984.
22. Wachsman, M. S., Damonte, E. B., Coto, C. E. and de Torres, R. A.: Antiviral effects of Melia azedarach L. leaves extracts on Sindbis virus infected cells. Antiviral Res. 8: 1-12, 1987.
23. Yoshikai, Y., Miake, S., Matsumoto, T., Nomoto, K. and Takeya, K.: Effect of stimulation and blockade of mononuclear phagocyte system on the delayed footpad reaction SRBC in mice. Immunology 38: 571-583, 1979.