Asymmetric hydrogenation vs. resolution in the synthesis of POSICOR®, a new type of calcium antagonist

Chimia

Volumn 51, Issue 6, 1997, Pages 303-305

  Crameri, Yvo ^b   Foricher, Joseph ^b   Hengartner, Urs ^b   Jenny, Christian Johannes ^b   Kienzle, Frank ^b   Ramuz, Henri ^b   Scalone, Michelangelo ^b   Schlageter, Markus ^b   Schmid, Rudolf ^a   Wang, Shaoning ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0002588666     PISSN: 00094293     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

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3. S.K. Mishra, K. Hermsmeyer, Circ. Res. 1994, 75, 144.
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11. The Ru(BINAP)-catalyzed asymmetric hydrogenation of 2,3-dimethyl-2-butenoic acid has been reported to afford 70% ee; see T. Ohta, H. Takaya, M. Kitamura, K. Nagai, R. Noyori, J. Org. Chem. 1987, 52, 3176. Very recently, after completion of our work, a higher ee of 88% has been achieved using a Ru(Octahydro-BINAP)-catalyst; see T. Uemura, X. Zhang, K. Matsumura, N. Sayo, H. Kumobayashi, T. Ohta, K. Nozaki, H. Takaya, J. Org. Chem. 1996, 61, 5510.
12. The Ru(BINAP)-catalyzed asymmetric hydrogenation of 2,3-dimethyl-2-butenoic acid has been reported to afford 70% ee; see T. Ohta, H. Takaya, M. Kitamura, K. Nagai, R. Noyori, J. Org. Chem. 1987, 52, 3176. Very recently, after completion of our work, a higher ee of 88% has been achieved using a Ru(Octahydro-BINAP)-catalyst; see T. Uemura, X. Zhang, K. Matsumura, N. Sayo, H. Kumobayashi, T. Ohta, K. Nozaki, H. Takaya, J. Org. Chem. 1996, 61, 5510.
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