Treatment of Chronic Hepatitis D with Interferon Alfa-2a

New England Journal of Medicine

Volumn 330, Issue 2, 1994, Pages 88-94

  Farci, Patrizia ^a   Mandas, Antonella ^a   Coiana, Alessandra ^a   Lai, Maria Eliana ^a   Desmet, Valeer ^b   Van Eyken, Peter ^b   Gibo, Yukio ^b   Caruso, Luciano ^c   Scaccabarozzi, Sergio ^d   Criscuolo, Domenico ^d   Ryff, Jean Charles ^e   Balestrieri, Angelo ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF CATANIA   (Italy)

^d ROCHE MILANO RICERCHE   (Italy)

^e F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2A INTERFERON; VIRUS RNA;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALOPECIA; ARTICLE; ASTHENIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELTA AGENT HEPATITIS; DOSE RESPONSE; DRUG EFFICACY; FEMALE; HEPATITIS DELTA VIRUS; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RELAPSE; STATISTICAL ANALYSIS; VIRUS ISOLATION; VIRUS REPLICATION;

ADOLESCENT; ADULT; ALANINE TRANSAMINASE; CHRONIC DISEASE; FEMALE; FOLLOW-UP STUDIES; HEPATITIS D; HUMANS; INTERFERON ALFA-2A; LIVER; MALE; MIDDLE AGED; NECROSIS;

EID: 0002193196     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199401133300202     Document Type: Article

References (33)

1. Rizzetto M, Verme G Delta hepatitis -- present status. J Hepatol 1985; 1: 187-193
2. Taylor J Structure and replication of hepatitis delta virus. Semin Virol 1990; 1: 135-141
3. Purcell RH, Gerin JL. Hepatitis delta virus. In: Fields BN, Knipe DM, eds. Fields virology. 2nd ed. Vol. 2. New York: Raven Press, 1990:2275-87.
4. Rizzetto M, Verme G, Gerin JL, Purcell RH. Hepatitis delta virus disease. In: Popper H, Schaffner F, eds. Progress in liver disease. Vol. VIII. Orlando, Fla.: Grune & Stratton, 1986:417-31.
5. Hoofnagle JH Type D δ hepatitis. JAMA 1989; 261: 1321-1325 [Erratum, JAMA 1989;261:3552.]
6. Bonino F, Negro F, Baldi M, et al. The natural history of chronic delta hepatitis. In: Rizzetto M, Gerin JL, Purcell RH, eds. The hepatitis delta virus and its infection. Vol. 234 of Progress in clinical and biological research. New York: Alan R. Liss, 1987:145-52.
7. Smedile A, Farci P, Verme G, Influence of delta infection on severity of hepatitis B. Lancet 1982; 2: 945-947
8. Rizzetto M, Verme G, Recchia S, Chronic hepatitis in carriers of hepatitis B surface antigen, with intrahepatic expression of delta antigen: an active and progressive disease unresponsive to immunosuppressive treatment. Ann Intern Med 1983; 98: 437-441
9. Peters M Mechanisms of action of interferons. Semin Liver Dis 1989; 9: 235-239
10. Thomas HC, Farci P, Shein R, et al. Inhibition of hepatitis delta virus (HDV) replication by lymphoblastoid human alpha interferon. In: Rizzetto M, Gerin JL, Purcell RH, eds. The hepatitis delta virus and its infection. Vol. 234 of Progress in clinical and biological research. New York: Alan R. Liss, 1987:277-90.
11. Hoofnagle J, Mullen K, Peters M, et al. Treatment of chronic delta hepatitis with recombinant human alpha interferon. In: Rizzetto M, Gerin JL, Purcell RH, eds. The hepatitis delta virus and its infection. Vol. 234 of Progress in clinical and biological research. New York: Alan R. Liss, 1987:291-8.
12. Rosina F, Saracco G, Lattore V, et al. Alpha 2 recombinant interferon in the treatment of chronic hepatitis delta virus (HDV) hepatitis. In: Rizzetto M, Gerin JL, Purcell RH, eds. The hepatitis delta virus and its infection. Vol. 234 of Progress in clinical and biological research. New York: Alan R. Liss, 1987:299-303.
13. Hoofnagle JH, Di Bisceglie AM. Therapy of chronic viral hepatitis: chronic hepatitis D and non-A, non-B hepatitis. In: Zuckerman AJ, ed. Viral hepatitis and liver disease. New York: Alan R. Liss, 1988:823-30.
14. Farci P, Karayiannis P, Brook MG, Treatment of chronic hepatitis delta virus (HDV) infection with human lymphoblastoid alpha interferon. Q J Med 1989; 73: 1045-1054
15. Di Bisceglie AM, Martin P, Lisker-Melman M, Therapy of chronic delta hepatitis with interferon alfa-2b. J Hepatol 1990; 11: Suppl 1: S151-S154
16. Porres JC, Carreno V, Bartolome J, Moreno A, Galiana F, Quiroga JA Treatment of chronic delta infection with recombinant human interferon alpha 2c at high doses. J Hepatol 1989; 9: 338-344
17. Marinucci G, Hassan G, Di Giacomo C, et al. Long term treatment of chronic delta hepatitis with alpha recombinant interferon. In: Gerin JL, Purcell RH, Rizzetto M, eds. The hepatitis delta virus. Vol. 364 of Progress in clinical and biological research. New York: Wiley-Liss, 1991:405-10.
18. Rosina F, Pintus C, Meschievitz C, Rizzetto M A randomized controlled trial of a 12-month course of recombinant human interferon-alpha in chronic delta (type D) hepatitis: a multicenter Italian study. Hepatology 1991; 13: 1052-1056
19. Hadziyannis SJ Use of alpha-interferon in the treatment of chronic delta hepatitis. J Hepatol 1991; 13: Suppl 1: S21-S26
20. Farci P, Orgiana G, Coiana A, et al. Epidemiology of HDV infection in Sardinia, an island with a high endemicity for HBV: a multicenter study. In: Gerin JL, Purcell RH, Rizzetto M, eds. The hepatitis delta virus. Vol. 364 of Progress in clinical and biological research. New York: Wiley-Liss, 1991:41-50.
21. Knodell RG, Ishak KG, Black WC, Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1: 431-435
22. van den Oord JJ, de Vos R, Desmet VJ In situ distribution of major histocompatibility complex products and viral antigens in chronic hepatitis B virus infection: evidence that HBc-containing hepatocytes may express HLA-DR antigens. Hepatology 1986; 6: 981-989
23. Farci P, Gerin JL, Aragona M, Diagnostic and prognostic significance of the IgM antibody to the hepatitis delta virus. JAMA 1986; 255: 1443-1446
24. Lai ME, Farci P, Figus A, Balestrieri A, Arnone M, Vyas GN Hepatitis B virus DNA in the serum of Sardinian blood donors negative for the hepatitis B surface antigen. Blood 1989; 73: 17-19
25. Cheley S, Anderson R A reproducible microanalytical method for the detection of specific RNA sequences by dot-blot hybridization. Anal Biochem 1984; 137: 15-19
26. Hennes U, Jucker W, Fischer EA, The detection of antibodies to recombinant interferon alfa-2a in human serum. J Biol Stand 1987; 15: 231-244
27. Dorr RT Interferon-alpha in malignant and viral diseases: a review. Drugs 1993; 45: 177-211
28. Saracco G, Rosina F, Brunetto MR, Rapidly progressive HBsAg-positive hepatitis in Italy: the role of hepatitis delta virus infection. J Hepatol 1987; 5: 274-281
29. Baron S, Tyring SK, Fleischmann WR Jr, The interferons: mechanisms of action and clinical applications. JAMA 1991; 266: 1375-1383
30. Katkov WN, Dienstag JL Prevention and therapy of viral hepatitis. Semin Liver Dis 1991; 11: 165-174
31. Perrillo RP, Schiff ER, Davis GL, A randomized, controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. N Engl J Med 1990; 323: 295-301
32. Davis GL, Balart LA, Schiff ER, Treatment of chronic hepatitis C with recombinant interferon alfa: a multicenter randomized, controlled trial. N Engl J Med 1989; 321: 1501-1506
33. Thomas HC, Montano L, Goodall A, de Koning R, Oladapo J, Wiedman KH Immunological mechanisms in chronic hepatitis B virus infection. Hepatology 1982; 2: 116S-121S