Direct Labeling of Monoclonal Antibodies and Antibody Fragments with 188Re Using a Weak Competing Ligand

Radiochimica Acta

Volumn 79, Issue 1, 1997, Pages 63-70

  Ferro Fiores, Guillermina ^a   Hashimoto, Kazuyuki ^b  

^a INSTITUTO NACIONAL DE INVESTIGACIONES NUCLEARES   (Mexico)

^b JAPAN ATOMIC ENERGY AGENCY   (Japan)

Author keywords

Direct labeling; EHDP; F(ab')2 fragments; Monoclonal antibodies; Rhenium 188

Indexed keywords

EID: 0002137633     PISSN: 00338230     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. 99mTc. Cancer Res. 50, 909 (1990).
2. Benz, P., Oberhausen, E., Berberich, R.: Monoclonal antibody BW431/26 labelled with Technetium-99m and indium-111: an investigation of the biodistribution and the dosimetry in patients. Eur. J. Nucl. Med. 18, 813 (1991).
3. Callahan, A. P., Rice, D. E., Knapp, F. F. Jr.: Rhenium-188 for therapeutic applications from an alumina-based tungsten-188/rhenium-188 radionuclide generator. NucCompact 20, 3 (1989).
4. 188Re generators. Appl. Radiat. Isot. 45, 123 (1994).
5. 188Re. Appl. Radiat. Isot. 47, 195 (1996).
6. Fritzberg, A. R., Vanderheyden J-L, A. C., Schroff, R. W., Abrams, P. G.: Rhenium-186/-188 labelled antibodies for radioimmunotherapy. In Technetium and Rhenium in Chemistry and Nuclear Medicine (M. Nicolini, G. Brandoli, U. Mazzi, eds.). Raven Press, New York 1990.
7. Griffith, G. L., Knapp, F. F., Callahan, A. P., Chang, C. H., Goldenberg, D. M., Hansen, H. J.: Direct radiolabeling of monoclonal antibodies with generator produced rhenium- 188 for radioimmunotherapy: labeling and animal biodistribution studies. Cancer Res. 51, 4594 (1991).
8. Schmidt, F., Smith, S. V., Bundesen, P.: Re-188 labelling of DD-3B6/22 Fab' antibody for radioimmunotherapy. J. Labell. Comp. Radiopharm. 36, 533 (1995).
9. Rhodes, B. A., Lambert, C. R., Marek, M. J., Knapp, F. F., Harvey, E. B.: Re-188 labeled antibodies. Appl. Radiat. Isot. 47, 7 (1996).
10. Fand, I., Sharkey, R. M., Grundy, J. P., Goldenberg, D. M.: Localization of whole-body autoradiography of intact and fragmented radiolabeled antibodies in a metastasic human colonic cancer model. Nucl. Med. Biol. 19, 87 (1992).
11. Goldenberg, D. M., Wlodkowski, T. J., Sharkey, R. M., Silberstein, E. B., Serafmi, A. N., Garty, I., Van-Heertum, R. L., Higginbotham-Ford, E. A., Kotler, J. A., Balasubramanian, N., Swayne, L. C., Hansen, H. J., Pinsky, C. M.: Colorectal cancer imaging with iodine-123-labeled CEA monoclonal antibody fragments. J. Nucl. Med. 34, 61 (1993).
12. 2 radioimmunoconjugate by direct labeling methods. Nucl. Med. Biol. 21, 649 (1994).
13. 2 fragments of an anti-CEA murine monoclonal antibody (Immu-14). Nucl Med. Biol. 22, 425 (1995).
14. 99mTc-EHDP-MoAb-IOR CEA1 Complex. Nucl. Med. Biol. 21, 1013 (1994).
15. Deutsch, E., Libson, K., Vanderheyden J-L, A. C., Ketring, A. R., Maxon, H. R.: The chemistry of rhenium and technetium as related to the use of isotopes of these elements in therapeutic and diagnostic nuclear medicine. Nucl. Med. Biol. 13, 465 (1986).
16. 186, 188Re for Nuclear Medicine. In Topics in Current Chemistry (J. D. Dunitz, K. Hafner, S. Ito, J. M. Lehnk, eds), Springer-Verlag, Berlin Heidelberg (1996).
17. John, E., Thakur, M. L., DeFulvio, J., McDevitt, M. R., Damjanov, I.: Rhenium-186-labeled monoclonal antibodies for radioimmunotherapy: preparation and evaluation. J. Nucl. Med. 34, 260 (1993).
18. Hnatowich, D. J., Mardirossian, G., Rusckowski, M., Fogarasi, M., Virzi, F., Winnard, P., Directly and indirectly technetium-99m-labeled antibodies - A comparison of in vitro and animal in vivo properties. J. Nucl. Med. 34, 109 (1993).