The Role of the dpp-Group Genes in Dorsoventral Patterning of the Drosophila Embryo

Advances in Developmental Biology (1992)

Volumn 4, Issue C, 1996, Pages 27-82

  Rushlow, Christine ^a   Roth, Siegfried ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0002136106     PISSN: 15663116     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1566-3116(08)60016-X     Document Type: Article

References (149)

1. Abrams J.M., White K., Fessler L.I., and Steller H. Programmed cell death during Drosophila embryogenesis. Development 117 (1993) 29-43
2. Affolter M., Nellen D., Nussbaumer U., and Basler K. Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGFβ homologs during Drosophila embryogenesis. Development 120 (1994) 3105-3117
3. Anderson K.V., Jürgens G., and Nüsslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product. Cell 42 (1985) 779-789
4. Anderson K.V., Bokla L., and Nüsslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: The induction of polarity by the Toll gene product. Cell 42 (1985) 791-798
5. Anderson, K. V., Schneider, D. S., Morisato, D., Jin, Y., & Ferguson, E.L. (1992). Extracellular morphogens in Drosophila embryonic dorsal-ventral patterning. Cold Spring Harbor Symp. Quant. Biol. 57, 409-417.
6. Arendt D., and Nübler-Jung K. Inversion of the dorsoventral axis. Nature 371 (1994) 26
7. Arora K., and Nüsslein-Volhard C. Altered mitotic domains reveal fate map changes in Drosophila embryos mutant for zygotic dorsoventral patterning genes. Development 114 (1992) 1003-1024
8. Arora K., Levine M., and O'Connor M.B. The screw gene encodes a ubiquitously expressed member of the TGF-β family required for specification of dorsal cell fates in the Drosophila embryo. Genes & Dev. 8 (1994) 2588-2601
9. Attisano L., Wrana J.L., Lopez-Casillas F., and Massagué J. TGF-β receptors and actions. Biochem. Biophys. Acta 1222 (1994) 71-80
10. Barr P.J. Mammalian subtilisins: The long-sought dibasic processing endoproteases. Cell 66 (1991) 1-3
11. Basler K., and Struhl G. Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature 368 (1994) 208-214
12. Bier E., Jan L.Y., and Jan Y.N. rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster. Genes & Dev. 4 (1990) 190-203
13. Boulay J.-L., Dennefeld C., and Alberga A. The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers. Nature 330 (1987) 395-398
14. Bradham D.M., Igarashi A., Potter R.L., and Grotendorst G. Connective tissue growth factor: A cysteine-rich secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J. Cell Biol. 114 (1991) 1285-1294
15. Brummel T.J., Twombly V., Marqués G., Wrana J.L., Newfeld S.J., Attisano L., Massagué J., O'Connor M.B., and Gelbart W.M. Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila. Cell 78 (1994) 251-261
16. Campbell G., Weaver T., and Tomlinson A. Axis specification in the developing Drosophila appendage: The role of wingless, decapentaplegic and the homeobox gene aristaless. Cell 74 (1993) 1113-1123
17. Campos-Ortega J.A., and Hartenstein V. The Embryonic Development of Drosophila melanogaster (1985), Springer Verlag, Berlin
18. Childs S.R., and O'Connor M.B. Two domains of the tolloid protein contribute to its unusual genetic interaction with decapentaplegic. Dev. Biol. 162 (1993) 209-220
19. Childs S.R., Wrana J.L., Arora K., Attisano L., O'Connor M.B., and Massagué J. Identification of a Drosophila activin receptor. Proc. Natl. Acad. Sci. USA 90 (1993) 9475-9479
20. Crews S.T., Thomas J.B., and Goodman C.S. The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product. Cell 52 (1988) 143-151
21. Dale L., Howes G., Price B.M.J., and Smith J.C. Bone morphogenetic protein 4: A ventralizing factor in Xenopus development. Development 115 (1992) 573-585
22. Dale L., Matthews G., and Colman A. Secretion and mesoderm-inducing activity of the TGF-beta-related domain of Xenopus Vgl. EMBO J. 12 (1993) 4471-4480
23. Doyle H.J., Harding K., Hoey T., and Levine M. Transcripts encoded by a homeobox gene are restricted to dorsal tissues of Drosophila embryos. Nature 323 (1986) 76-79
24. Doyle H.J., Kraut R., and Levine M. Spatial regulation of zerknüllt. A dorsal-ventral patterning gene in Drosophila. Genes & Dev. 3 (1989) 1518-1533
25. Fainsod A., Steinbeisser H., and de Robertis E.M. On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo. EMBO J. 13 (1994) 5015-5025
26. Ferguson E.L., and Anderson K.V. Dorsal-ventral pattern formation in the Drosophila embryo: The role of zygotically active genes. Current Topics Dev. Biol. 25 (1991) 17-43
27. Ferguson E.L., and Anderson K.V. Localized enhancement and repression of the activity of the TGF-β family member, decapentaplegic is necessary for dorsal-ventral pattern formation in the Drosophila embryo. Development 114 (1992) 583-597
28. Ferguson E.L., and Anderson K.V. Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo. Cell 71 (1992) 451-461
29. Foe V. Mitotic domains reveal early commitment of cells in Drosophila embryos. Development 107 (1989) 1-22
30. François V., and Bier E. Xenopus chordin and Drosophila short gastrulation genes encode homologous proteins functioning in dorsal-ventral axis formation. Cell 80 (1995) 19-20
31. François V., Solloway M., O'Neill J.W., Emery J., and Bier E. Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene. Genes & Dev. 8 (1994) 2602-2616
32. Geisler R., Bergmann A., Hiromi Y., and Nüsslein-Volhard C. cactus, a gene involved in dorsoventral pattern formation of Drosophila is related to the I kappa B gene family of vertebrates. Cell 71 (1992) 613-621
33. González-Crespo S., and Levine M. Interactions between dorsal and helix-loop-helix proteins initiate the differentiation of the embryonic mesoderm and neuroectoderm in Drosophila. Genes & Dev. 7 (1993) 1703-1713
34. Graff J.M., Thies R.S., Song J.J., Celeste A.J., and Melton D.A. Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo. Cell 79 (1994) 169-179
35. Green J.B.A., and Smith J.C. Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate. Nature 347 (1990) 391-394
36. Green J.B.A., New H.V., and Smith J.C. Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 71 (1992) 731-739
37. Gurdon J.B., Harger P., Mitchell A., and Lemaire P. Activin signalling and response to a morphogen gradient. Nature 371 (1994) 487-492
38. Green J.B.A., New H.V., and Smith J.C. Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm. Cell 71 (1992) 731-739
39. Hammerschmidt M., and Nusslein-Volhard C. The expression of a zebrafish gene homologous to Drosophila snail suggests a conserved function in invertebrate and vertebrate gastrulation. Development 119 (1993) 1107-1118
40. Han K., Levine M.S., and Manley J.L. Synergistic activation and repression of transcription by Drosophila homeobox proteins. Cell 56 (1989) 573-583
41. Hashimoto C., Hudson K.L., and Anderson K.V. The Toll gene of Drosophila required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 52 (1988) 269-279
42. Heberlein U., Wolff T., and Rubin G.M. The TGF beta homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina. Cell 75 (1993) 913-926
43. Hoch M., Schröder C., Seifert E., and Jäckle H. Cis-acting control elements for Krüppel expression in the Drosophila embryo. EMBO J. 9 (1990) 2587-2595
44. Hoey T., and Levine M. Divergent homeobox proteins recognize similar DNA sequences in Drosophila. Nature 332 (1988) 858-861
45. Hopwood N.D., Pluck A., and Gurdon J.B. A Xenopus mRNA related to Drosophila twist is expressed in response to induction in the mesoderm and the neural crest. Cell 59 (1989) 893-903
46. Huang J.D., Schwyter D.H., Shirokawa J.M., and Courey A.J. The interplay between multiple enhancer and silencer elements defines the pattern of decapentaplegic expression. Genes Dev. 7 (1993) 694-704
47. Ip Y.T., Kraut R., Levine M., and Rushlow C.A. The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in Drosophila. Cell 64 (1991) 439-446
48. Ip Y.T., and Levine M. The role of the dorsal morphogen gradient in Drosophila embryogenesis. Sem. Dev. Biol. 3 (1992) 15-23
49. Ip Y.T., Park R.E., Kosman D., Bier E., and Levine M. The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo. Genes & Dev. 6 (1992) 1728-1739
50. Ip Y.T., Park R.E., Kosman D., Yazdanbakhsh K., and Levine M. Dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo. Genes & Dev. 6 (1992) 1518-1530
51. Irish V.F., and Gelbart W.M. The decapentaplegic gene is required for dorsal-ventral patterning of the Drosophila embryo. Genes & Dev. 1 (1987) 868-879
52. Jackson P.D., and Hoffmann F.M. Embryonic expression patterns of the Drosophila decapentaplegic gene: Separate regulatory elements control blastoderm expression and lateral ectodermal expression. Dev. Dyn. 199 (1994) 28-44
53. Jacob Y., Sather S., Martin J.R., and Ollo R. Analysis of Krüppel control elements reveals that localized expression results from the interaction of multiple subelements. Proc. Natl. Acad. Sci. USA 88 (1991) 5912-5916
54. Jiang J., and Levine M. Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen. Cell 72 (1993) 741-752
55. Jiang J., Kosman D., Ip Y.T., and Levine M. The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos. Genes & Dev. 5 (1991) 1881-1891
56. Jiang J., Rushlow C.A., Zhou Q., Small S., and Levine M. Individual dorsal binding sites mediate activation and repression in the Drosophila embryo. EMBO J. 11 (1992) 3147-3154
57. Jiang J., Cai H., Zhou Q., and Levine M. Conversion of a dorsal-dependent silencer into an enhancer: Evidence for dorsal corepressors. EMBO J. 12 (1993) 3201-3209
58. Jones C.M., Lyons K.M., Lapan P.M., Wright C.V.E., and Hogan B.J.M. DVR-4 (bone morphogenetic protein-4) as a postero-ventralizing factor in Xenopus mesoderm induction. Development 115 (1992) 639-647
59. Jürgens G., Wieschaus E., and Nüsslein-Volhard C. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster II: Zygotic loci on the third chromosome. Roux's Archives of Developmental Biology 193 (1984) 283-295
60. Kaphingst K., and Kunes S. Pattern formation in the visual centers of the Drosophila brain: wingless acts via decapentaglegic to specify the dorsoventral axis. Cell 78 (1994) 437-448
61. Kessler D.S., and Melton D.A. Vertebrate embryonic induction: Mesodermal and neural patterning. Science 266 (1994) 596-604
62. Kidd S. Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins. Cell 71 (1992) 623-635
63. Kim S.H., and Crews S.T. Influence of Drosophila ventral epidermal development by the CNS midline cells and spitz class genes. Development 118 (1993) 893-901
64. Kingsley D.M. The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms. Genes & Dev. 8 (1994) 133-146
65. Kingsley D.M. What do BMPs do in mammals? Clues from the mouse short ear mutation. Trends Genet. 10 (1994) 16-21
66. Kirov N., Zhelnin L., Shah J., and Rushlow C. Conversion of a silencer into an enhancer: Evidence for a co-repressor in dorsal-mediated repression in Drosophila. EMBO J. 12 (1993) 3193-3199
67. Kirov N., Childs S., O'Connor M., and Rushlow C. The Drosophila dorsal morphogen represses the tolloid gene by interacting with a silencer element. Mol. Cell. Biol. 14 (1994) 713-722
68. Konrad K.D., Goralski T.J., and Mahowald A.P. Developmental genetics of the gastrulation defective locus in Drosophila melanogaster. Developmental Biology 127 (1988) 133-142
69. Kosman D., Ip Y.T., Levine M., and Arora K. Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryo. Science 254 (1991) 118-122
70. Lacalli T.C. Dorsoventral axis inversion. Nature 373 (1995) 110-111
71. Lehming N., Thanos D., Brickman J.M., Ma J., Maniatis T., and Ptashne M. An HMG-like protein that can switch a transcriptional activator to a repressor. Nature 371 (1994) 175-179
72. Leptin M. twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes & Dev. 5 (1991) 1568-1576
73. Leptin M., and Grunewald B. Cell shape changes during gastrulation in Drosophila. Development 110 (1990) 73-84
74. Lyons, K. M., Jones, C. M., & Hogan, B.L. (1992). The TGF-beta-related DVR gene family in mammalian development. Ciba Found. Symp. 165, 219-230; 230-234.
75. Maeno M., Ong C.R., Suzuki A., Ueno N., and Kung H.-F. A truncated bone morphogenetic protein 4 receptor alters the fate of ventral mesoderm to dorsal mesoderm: Roles of animal pole tissue in the development of the ventral mesoderm. Proc. Natl. Acad. Sci. USA 91 (1994) 10260-10264
76. Mason E.D., Konrad K.D., Webb C.D., and Marsh L.J. Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein related to human connective tissue growth factor. Genes & Dev. 8 (1994) 1489-1501
77. Massagué J., Attisano L., and Wrana J.L. The TGF-β family and its composite receptors. Trends Cell Biol. 4 (1994) 172-178
78. Mayer U., and Nüsslein-Volhard C. A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo. Genes and Development 2 (1988) 1496-1511
79. Meinhardt H. Models of Biological Pattern Formation (1982), Academic Press, London
80. Morisato D., and Anderson K.V. The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo. Cell 76 (1994) 677-688
81. Murphy-Ullrich J.E., Schultz-Cherry S., and Hook M. Transforming growth factor-β complexes with thrombospondin. Mol. Biol. Cell. 3 (1992) 181-188
82. Nambu J.R., Frank R.G., Hu S., and Crews S.T. The single-minded gene of Drosophila is required for the expression of genes important for the development of CNS midline cells. Cell 63 (1990) 63-75
83. Nellen D., Affolter M., and Basler K. Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. Cell 78 (1994) 225-237
84. Nguyen T., Jamal J., Shimell M.J., Arora K., and O'Connor M.B. Characterization of tolloid related-1: A BMP-1-like product that is required during larval and pupal states of Drosophila development. Dev. Biol. 166 (1994) 569-586
85. Nubler K., and Arendt D. Is ventral in insects dorsal in vertebrates. Roux's Arch. Dev. Biol. 203 (1994) 357-366
86. Nüsslein-Volhard C. Maternal effect mutations that alter the spatial coordinates of the embryo of Drosophila melanogaster. In: Subtelny S., and Koenigsberg I.R. (Eds). Determinants of Spatial Organization (1979), Academic Press, New York 185-211
87. Nüsslein-Volhard C., Wieschaus E., and Kluding J. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster I: Zygotic loci on the second chromosome. Roux's Archives of Developmental Biology 193 (1984) 267-282
88. Ozkaynak E., Ruegér D.C., Drier E.A., Corbett C., Ridge R.J., Sampath T.K., and Oppermann H. Op-1 cDNA encodes an osteogenic protein in the TGF-β family. EMBO J. 9 (1990) 2085-2093
89. Padgett R.W., Johnson R.D.S., and Gelbart W.M. A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family. Nature 325 (1987) 81-84
90. Padgett R.W., Wozney J.M., and Gelbart W.M. Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo. Proc. Natl. Acad. Sci. USA 90 (1993) 2905-2909
91. Pan D., Huang J.-D., and Courey A.J. Functional analysis of the Drosophila twist promoter reveals a dorsal-binding ventral activator region. Genes & Dev. 5 (1991) 1892-1901
92. Panganiban G.E., Rashka K.E., Neitzel M.D., and Hoffmann F.M. Biochemical characterization of the Drosophila DPP protein, a member of the transforming growth factor β family of growth factors. Molecular and Cellular Biology 10 (1990) 2669-2677
93. Paralkar V.M., Hammonds R.G., and Reddi A.H. Transforming growth factor beta type 1 binds to collagen IV of basement membrane matrix: Implications for development. Dev. Biol. 143 (1991) 303-308
94. Penton A., Chen Y., Staehling-Hampton K., Wrana J.L., Attisano L., Szidonya J., Cassill J.A., Massagué J., and Hoffmann F.M. Identification of two bone morphogenetic protein Type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor. Cell 78 (1994) 239-250
95. Peterson K.J. Dorsoventral axis inversion. Nature 373 (1995) 111-112
96. Posakony L.G., Raftery L.A., and Gelbart W.M. Wing formation in Drosophila melanogaster requires decapentaplegic gene function along the anterior-posterior compartment boundary. Mech. Dev. 33 (1990) 69-82
97. Raftery L.A., Twombly V., Wharton K., and Gelbart W.M. Genetics screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139 (1995) 241-254
98. Rao Y., Vaessin H., Jan L.Y., and Jan Y.-N. Neuroectoderm in Drosophila embryos is dependent on the mesoderm for positioning but not for formation. Genes and Development 5 (1991) 1577-1588
99. Ray, R.B. (1993). Dorsal-ventral patterning in the Drosophila embryo. Ph.D. thesis, Harvard University.
100. Ray R.P., Arora K., Nüsslein-Volhard C., and Gelbart W.M. The control of cell fate along the dorsal-ventral axis of the Drosophila embryo. Development 113 (1991) 35-54
101. Roth S. Mechanisms of dorsal-ventral axis determination in Drosophila embryos revealed by cytoplasmic transplantations. Development 117 (1993) 1385-1396
102. Roth S., Stein D., and Nüsslein-Volhard C. A gradient of nuclear localization of the Dorsal protein determines dorsoventral pattern in the Drosophila embryo. Cell 59 (1989) 1189-1202
103. Roth S., Hiromi Y., Godt D., and Nüsslein-Volhard C. Cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos. Development 112 (1991) 371-388
104. Rushlow C.A., and Arora K. Dorsal-ventral polarity and pattern formation in Drosophila. Pattern formation in Drosophila. Sem. Cell Biol. 1 (1990) 173-184
105. Rushlow C., and Levine M. Role of the zerknüllt gene in dorsal-ventral pattern formation in Drosophila. Adv. Genet. 27 (1990) 277-307
106. Rushlow C., and Warrior R. The rel family of proteins. BioEssays 14 (1992) 89-95
107. Rushlow C.A., Frasch M., Doyle H., and Levine M. Maternal regulation of zerknüllt: A homeobox gene controlling differentiation of dorsal tissues in Drosophila. Nature 330 (1987) 583-586
108. Rushlow C.A., Han K., Manley J.L., and Levine M. The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila. Cell 59 (1989) 1165-1177
109. Rutledge B.J., Zhang K., Bier E., Jan Y.N., and Perrimon N. The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes & Dev. 6 (1992) 1503-1517
110. Sampath T.K., Rashka K.E., Doctor J.S., Tucker R.F., and Hoffman F.M. Drosophila transforming growth factor β superfamily proteins induce endochondral bone formation in mammals. Proc. Natl. Acad. Sci. USA 90 (1993) 6004-6008
111. Sargent M.G., and Bennett M.F. Identification in Xenopus of a structural homologue of the Drosophila gene snail. Development 109 (1990) 967-973
112. Sasai Y., Lu B., Steinbeisser H., Geissert D., Gont L.K., and de Robertis E.M. Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes. Cell 79 (1994) 779-790
113. Schneider D.S., Hudson K.L., Lin T.Y., and Anderson K.V. Dominant and recessive mutations define functional domains of Toll a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo. Genes & Dev. 5 (1991) 797-807
114. Schneider D.S., Jin Y., Morisato D., and Anderson K.V. A processed form of the Spatzle protein defines dorsal-ventral polarity in the Drosophila embryo. Development 120 (1994) 1243-1250
115. Schüpbach T., and Wieschaus E. Female sterile mutations on the second chromosome of Drosophila melanogaster I. Maternal effect mutations. Genetics 121 (1989) 101-117
116. Schüpbach T., and Wieschaus E. Maternal-effect mutations altering the anterior-posterior pattern of the Drosophila embryo. Roux's Archives of Developmental Biology 195 (1986) 302-317
117. Scott M.P. Intimations of a creature. Cell 79 (1994) 1121-1124
118. Sekelsky J.J., Newfeld S.J., Raftery L.A., Chartoff E.H., and Gelbart W.M. Genetic characterization and cloning of Mothers against dpp a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139 (1995) 1347-1358
119. Shimell M.J., Ferguson E.L., Childs S.R., and O'Connor M.B. The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein 1. Cell 67 (1991) 469-481
120. Simpson P. Maternal-zygotic gene interactions during formation of the dorsoventral pattern in Drosophila embryos. Genetics 105 (1983) 615-632
121. Smith D.E., Franco del Amo F., and Gridley T. Isolation of Sna a mouse gene homologous to the Drosophila genes snail and escargot: Its expression pattern suggests multiple roles during postimplantation development. Development 116 (1992) 1033-1039
122. Spencer F.A., Hoffmann F.M., and Gelbart W.M. Decapentaplegic: A gene complex affecting morphogenesis in Drosophila melanogaster. Cell 28 (1982) 451-461
123. St. Johnston R.D., and Gelbart W.M. Decapentaplegic transcripts are localized along the dorsal-ventral axis of the Drosophila embryo. EMBO J. 6 (1987) 2785-2791
124. St. Johnston R.D., and Nüsslein-Volhard C. The origin of pattern and polarity in the Drosophila embryo. Cell 68 (1992) 201-219
125. Staehling-Hampton K., Jackson P.D., Clark M.J., Brand A.H., and Hoffmann F.M. Specificity of bone morphogenetic protein-related factors: Cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A. Cell Growth & Diff. 5 (1994) 585-593
126. Stein D., and Nüsslein-Volhard C. Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity. Cell 68 (1992) 429-440
127. Stein D., Roth S., Vogelsang E., and Nüsslein-Volhard C. The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal. Cell 65 (1991) 725-735
128. Steward R. dorsal an embryonic polarity gene in Drosophila is homologous to the vertebrate proto-oncogene, c-rel. Science 238 (1987) 692-694
129. Steward R. Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function. Cell 59 (1989) 1179-1188
130. Technau G.M., and Campos-Ortega J.A. Cell autonomy of expression of neurogenic genes of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 84 (1987) 4500-4504
131. Terracol R., and Lengyel J.A. The thick veins gene of Drosophila is required for dorsoventral polarity of the embryo. Genetics 138 (1994) 165-178
132. Thisse B., Stoetzel C., Gorostiza-Thisse C., and Perrin-Schmitt F. Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos. EMBO J. 7 (1988) 2175-2183
133. Thisse C., Perrin-Schmitt F., Stoetzel C., and Thisse B. Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product. Cell 65 (1991) 1191-1201
134. Thomsen G.H., and Melton D.A. Processed Vgl protein is an axial mesoderm inducer in Xenopus. Cell 74 (1993) 433-441
135. Wakimoto B.T., Turner F.R., and Kaufman T.C. Defects in embryogenesis in mutants associated with the Antennapedia gene complex of Drosophila melanogaster. Dev. Biol. 102 (1984) 147-172
136. Wang E.A., Rosen V., Cordes P., Hewick R.M., Kriz M.J., Luxenberg D.P., Sibley B.S., and Wozney J.M. Purification and characterization of other distinct bone-inducing factors. Proc. Natl. Acad. Sci. USA 85 (1988) 9484-9488
137. Wang T., Donahoe P.K., and Zervos A.S. Specific interaction of type I receptors of the TGF-β family with the immunophilin FKBP-12. Science 265 (1994) 674-676
138. Weeks D.L., and Melton D.A. A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-β. Cell 51 (1987) 861-867
139. Wharton K.A., Thomsen G.H., and Gelbart W.M. Drosophila 60A gene, a new TGF-β family member is closely related to human bone morphogenetic proteins. Proc. Natl. Acad. Sci. USA 88 (1991) 9214-9218
140. Wharton K.A., Ray R.P., and Gelbart W.M. An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo. Development 117 (1993) 807-822
141. Wieschaus E., and Nüsslein-Volhard C. Looking at embryos. In: Roberts D.B. (Ed). Drosophila: A Practical Approach (1986), IRL Press, Washington DC 199-227
142. Wieschaus E., Nüsslein-Volhard C., and Jürgens G. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. II. Zygotic loci on the X-chromosome and fourth chromosome. Wilhelm Roux's Arch. Dev. Biol. 193 (1984) 296-307
143. Wolf C., Thisse C., Stoetzel C., Thisse B., Gerlinger P., and Perrin-Schmitt F. The M-twist of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genes. Dev. Biol. 143 (1991) 363-373
144. Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., and Wang E.A. Novel regulators of bone formation: Molecular clones and activities. Science 242 (1988) 1528-1534
145. Wrana J.L., Attisano L., Wieser R., Ventura F., and Massagué J. Mechanisms of activation of the TGF-β receptor. Nature 370 (1994) 341-347
146. Wrana J.L., Tran H., Attisano L., Arora K., Childs S.R., Massagué J., and O'Connor M.B. Two distinct transmembrane serine/threonine kinases from Drosophila melanogaster form an activin receptor complex. Mol. Cell. Biol. 14 (1994) 944-950
147. Xie T., Finelli A.L., and Padgett R.W. The Drosophila saxophone gene: A serine threonine kinase receptor of the TGF-beta superfamily. Science 263 (1994) 1756-1759
148. Zusman S.B., and Weischaus E. Requirement for zygotic gene activity during gastrulation in Drosophila melanogaster. Dev. Biol. 111 (1985) 359-371
149. Zusman S.B., Sweeton D., and Wieschaus E.F. Short gastrulation a mutation causing delays in stage specific cell shape changes during gastrulation in Drosophila melanogaster. Dev. Biol. 129 (1988) 417-427