Effects of beta-amyloid on cholinergic, cholinoceptive and GABAergic neurons

Acta Biologica Hungarica

Volumn 49, Issue 1, 1998, Pages 43-54

  Pákáski, Magdolna ^a   Papp, Henrietta ^a   Forgon, Mónika ^a   Kasa Jr P ^a   Penke, B ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Acetyl cholinesterase; Alzheimer's disease; Amyloid; GABA immunocytochemistry; Neuronal culture; Vesicular acetylcholine transporter

Indexed keywords

EID: 0002120241     PISSN: 02365383     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03542976     Document Type: Article

References (27)

1. 2+-dependent late phase. J. Neurochem. 67, 2074-2078.
2. Bartus, R. T., Dean, R. L. III, Beer, B., Lippa, S. (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217, 408-414.
3. Busciglio, J., Lorenzo, A., Yankner, B. A. (1992) Methodological variables in the assesssment of beta amyloid neurotoxicity. Neurobiol. Aging. 13, 609-612.
4. Coyle, J. T., Price, D. L., DeLong, M. R. (1983) Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 219, 1184-1190.
5. Emre, M., Geula, C., Ransil, B. J., Mesulam, M.-M. (1992) The acute neurotoxicity and effects upon cholinergic axons of intracerebrally injected β-amyloid in the rat brain. Neurobiol. Aging 13, 553-559.
6. (1-42) peptide on cortical projections of the rat nucleus basalis magnocellularis. Brain Res. 695, 71-75.
7. Kása, P., Pákáski, M., Penke, B. (1992) Synthetic human beta amyloid has selective vulnerable effects on different types of neurons and glial cells in in vitro cultures derived from embryonic rat brain cortex. Neurobiol. Aging 13, Suppl. 1, S104.
8. Kása, P., Pákáski, M., Penke, B. (1993) Synthetic human beta amyloid has selective vulnerable effects on different types of neurons. In: Nicolini, M., Zatta, P. F., Corain, B. (eds) Alzheimer's Disease and Related Disorders. Advances in the Biosciences 12, Pergamon Press, Oxford, pp. 311-312.
9. Kása, P., Pákáski, M., Zarándi, M., Forgon, M., Papp, H., Rakonczay, Z. (1998) Alterations in the distribution of acetylcholinesterase within the cholinergic and cholinoceptive neurons in in vitro tissue cultures in response to human amyloid β peptide and some of its fragments. Neurobiol. Aging 19, 549.
10. Kowall, N. W., Beal, M. F., Busciglio, J., Duffy, L. K., Yankner B. A. (1991) An in vivo model for neurodegenerative effects of β amyloid and protection by substance P. Proc. Natl. Acad. Sci. USA 88, 7247-7251.
11. Kowall, N. W., McKee, A. C., Yankner, B. A., Beal, M. F. (1992) In vivo neurotoxicity of beta amyloid [β(1-40)] and the [β(25-35)] fragment. Neurobiol. Aging 13, 537-542.
12. i in rat astrocytes. Biochem. Biophys. Res. Commun. 235, 479-481.
13. Manelli, A. M., Puttfarcken, P. S. (1995) β-Amyloid-induced toxicity in rat hippocampal cells: in vitro evidence for the involvement of free radicals. Brain Res. Bull. 38, 569-576.
14. Mesulam, M. M., Geula, C. (1992) Overlap between acetyl-cholinesterase-rich and choline acetyl-transferase-positive (cholinergic) axons in human cerebral cortex. Brain Res. 577, 112-120.
15. Mountjoy, C. Q., Rossor, M. N., Iversen, L. L, Roth, M. (1984) Correlation of cortical cholinergic and GABA deficits with quantitative neuropathological findings in senile dementia. Brain 107, 507-518.
16. Pákáski, M., Farkas, Z., Kása, P. Jr., Forgon, M., Papp, H., Zarándi, M., Penke, B., Kása, P. (1998) Vulnerability of small GABAergic neurons to human β-amyloid pentapeptide. Brain Res. 796, 239-246.
17. Papp, H., Pákáski, M., Penke, B, Kása, P. (1996) Effects of β-amyloid and its fragments on cholinergic and cholinoceptive neurons in vitro. Clin. Neurosci. 49, 49-50.
18. Pike, C. J., Walencewicz, A. J., Glabe, C. G, Cotman, C. W. (1991) In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 563, 311-314.
19. Pike, C. J., Cotman, C. W. (1993) Cultured GABA-immunoreactive neurons are resistant to toxicity induced by β-amyloid. Neuroscience 56, 269-274.
20. Pike, C. J., Burdick, D., Walencewicz, A. J., Glabe, C. G, Cotman, C. W. (1993) Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state. J. Neurosci. 13, 1676-1687.
21. Pike, C. J., Cotman, C. W. (1995) Calretinin-immunoreactive neurons are resistant to β-amyloid toxicity in vitro. Brain Res. 671, 293-298.
22. Rossor, M. N., Garret, N. J., Johnson, A. L., Mountjoy, C. Q., Roth, M., Iversen, L. L. (1982) A post-mortem study of the cholinergic and GABA systems in senile dementia. Brain 105, 313-330.
23. Shearman, M. S., Ragan, C. I., Iversen, L. L. (1994) Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of β-amyloid-mediated cell death. Proc. Natl. Acad. Sci. USA 91, 1470-1474.
24. Tago, H., Kimura, H., Maeda, T. (1986) Visualization of detailed acetylcholinesterase fiber and neuron staining in rat brain by a sensitive histochemical procedure. J. Histochem. Cytochem. 34, 1431-1438.
25. Walker, L. C., Kitt, C. A., Struble, R. G., Schmechel, D. E., Oertel, W. H., Cork, L. C., Price, D. L. (1985) Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques. Neurosci. Lett. 59, 165-169.
26. Wróblewski, F., LaDue, J. S. (1955) Lactic dehydrogenase activity in blood. Proc. Soc. Exp. Biol. Med. 90, 210-213.
27. Yankner, B. A., Duffy, L. K., Kirschner, D. A. (1990) Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 250, 279-282.