Tibolone: Vaginal bleeding and the specific endometrial response in postmenopausal women

Gynecological Endocrinology

Volumn 11, Issue SUPPL. 2, 1997, Pages 25-30

  Johannes, E J ^a  

^a NV ORGANON   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0002079101     PISSN: 09513590     EISSN: None     Source Type: Journal    
DOI: 10.3109/09513599709152592     Document Type: Article

References (11)

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2. Ginsburg, J., Prelevic, G., Butler, D. and Okolo, S. (1995). Clinical experience with tibolone (Livial®) over 8 years. Maturitas, 21, 71-6
3. Siseles, N. O., Halperin, H., Benencia, H. J., Berg, G., Pilnik, S., Mesch, V., Arrighi, B. and Wikinski, R. W. W. (1995). A comparative study of two hormone replacement therapy regimens on safety and efficacy variables. Maturitas, 21, 201-10
4. Punnonen, R., Luikko, P., Cortes-Prieto, J., Eydam, F., Milojevic, S., Trevoux, R., Chryssikopoulos, E., Franchi, F., Luis, M. and Kicovic, P. M. (1984). Multicentre study of the effects of Org OD14 on endometrium, vaginal cytology and cervical mucus in post-menopausal and oophorectomized women. Maturitas, 5, 281-6
5. Genazzani, A. R., Benedek-Jaszmann, L. J., Hart, D. M., Andolsek, L., Kicovic, P. M. and Tax, L. (1991). Org OD14 and the endometrium. Maturitas, 13, 243-51
6. Rymer, J., Fogelman, I. and Chapman, M. G. (1994). The incidence of vaginal bleeding with tibolone treatment. Br. J. Obstet. Gynaceol., 101, 53-66
7. Ginsburg, J. and Prelevic, G. M. (1996). Cause of vaginal bleeding in postmenopausal women taking tibolone. Maturitas, 24, 107-10
8. Bergeron, C. (1997). Microscopic evaluation of the effect of hormone replacement therapy on the endometrium in women who bleed. Gynecol. Endocrinol., 11 (Suppl. 2), 11-16
9. Hammar, M., Christau, S., Nathorst-Böös, J., Rud, T. and Garre, K. (1996). A double-blind, randomized study comparing the effects of Livial and Kliogest in postmenopausal women with climacteric complaints. Acta Obstet. Gynecol. Scand., 75, 52-3
10. Tang, B., Markiewicz, L., Kloosterboer, H. J. and Gurpide, E. (1993). Human endometrial 3β-hydroxysteroid dehydrogenase/isomerase can locally reduce intrinsic estrogenic/progestagenic activity ratios of a steroidal drug (Org OD14). J. Steroid Biochem. Mol. Biol., 45, 345-51
11. Markiewicz, L. and Gurpide, E. (1990). In vivo evaluation of estrogenic, estrogen antagonistic and progestogenic effects of a steroidal drug (Org OD14) and its metabolites on human endometrium. J. Steroid Biochem., 35, 535-42