Bioreactors designed for animal cells

Mammalian Cell Biotechnology in Protein Production

Volumn , Issue , 2011, Pages 279-318

  Tokashiki, Michiyuki ^a   Yokoyama, Seiichi ^a  

^a TEIJIN LTD   (Japan)

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EID: 0001973760     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (107)

1. Almgren, J., Nilsson, C., Petersson, A.C. and Nilsson, K. (1991) In: Production of Biologicals from Animal Cells in Culture (Spier, R. E., Griffiths, J. B. and Meignier, B., eds.), pp. 434-438, Butterworth-Heinemann, Oxford
2. Apelman, S. (1992) In: Animal Cell Technology: Basic & Applied Aspects (Murakami, H., Shirahata, S. and Tachibana, H., eds.) pp. 149-154, Kluwer Academic Publishers, Dordrecht
3. Berg, G.J. and Bödeker, B.G.D. (1988) In: Animal Cell Biotechnology, Vol. 3 (Spier, R.E. and Griffiths, J.B., eds.), pp. 321-335, Academic Press Ltd., London
4. Beyeler, W., Thaler, T. and Clements, R. (1990) In: Trends in Animal Cell Culture Technology (Murakami, H., ed.), pp. 225-230, Kodansha Ltd., Tokyo
5. Birch, J.R., Thompson, P.W., Lambert, K. and Boraston, R. (1985) In: Large-Scale Mammalian Cell Culture (Feder, J. and Tolbert, W.R., eds), pp. 1-18, Academic Press, Inc., Orlando
6. Brown, P.C., Costello, M. A.C., Oakley, R. and Lewis, J. L. (1985) In: Large-Scale Mammalian Cell Culture (Feder, J. and Tolbert, W.R., eds.), pp. 59-78, Academic Press, Inc., Orlando
7. Brown, P.C., Figueroa, C., Costello, M.A.C., Oakley, R. and Maciukas, S.M. (1988) In: Animal Cell Biotechnology, Vol. 3 (Spier, R.E. and Griffiths, J.B., eds.), pp. 251-262, Academic Press Ltd., London
8. Bugarski, B., King, G.A., Jovanovic, G., Daugulis, A.J. and Goosen, M.F.A. (1989) Perfomance of an external loop air-lift bioreactor for the production of monoclonal antibodies by immobilized hybridoma cells. Appl. Microbiol. Biotechnol. 30, 264-269
9. Butler, M. (1988) In: Animal Cell Biotechnology, Vol. 3 (Spier, R.E. and Griffiths, J.B., eds.), pp. 283-303, Academic Press Ltd., London
10. Cherry, R.S. and Papoutsakis, E.T. (1990) In: Animal Cell Biotechnology, Vol. 4 (Spier, R.E. and Griffiths, J.B., eds.), pp. 71-121, Academic Press Ltd., London
11. Croughan, M.S. and Wang, D.I.C. (1991) In: Animal Cell Bioreactors (Ho, C.S. and Wang, D.I.C., eds.), pp. 213-249, Butterworth-Heinemann, Stoneham
12. de Bruyne, N.A. (1988) In: Animal Cell Biotechnology, Vol. 3 (Spier, R.E. and Griffiths, J.B., eds.), pp. 141-176, Academic Press Ltd., London
13. Dean, Jr. R.C., Karkare, S.B., Phillips, P.G., Ray, N.G. and Runstadler, Jr., P.W. (1987) In: Large Scale Cell Culture Technology (Lydersen, B.K., ed.), pp. 145-167, Hanser Publishers, Munich, Vienna, New York
14. Duff, R.G. (1985) Microencapsulation technology: a novel method for monoclonal antibody production. Trends Biotechnol. 3, 167-170
15. Familletti, P.C. and Fredericks, J.E. (1988) Techniques for mammalian cell immobilization. Bio/Technology 6, 41-44
16. Fleischaker, R.J. and Sinskey, A.J. (1981) Oxygen demand and supply in cell culture. Eur. J. Appl. Microbiol. Biotechnol. 12, 193-197
17. Glacken, M.W., Fleischaker, R.J. and Sinskey, A.J. (1983) Mammalian cell culture: engineering principles and scale-up. Trends Biotechnol. 1, 102-108
18. Griffiths, J.B. (1985) In: Animal Cell Biotechnology, Vol. 1 (Spier, R.E. and Griffiths, J.B., eds.), pp. 49-83, Academic Press Inc. (London) Ltd
19. Griffiths, J.B. (1988) In: Animal Cell Biotechnology, Vol. 3 (Spier, R. E. and Griffiths, J. B., eds.), pp.179-220, Academic Press Ltd., London
20. Griffiths, B. (1990) In: Animal Cell Biotechnology, Vol. 4 (Spier, R. E. and Griffiths, J. B., eds.), pp. 149-166, Academic Press Ltd., London
21. Griffiths, B. (1990) Animal Cells-the breakthrough to a dominant technology. Cytotechnology 3, 109-116
22. Griffiths, B. and Looby, D. (1991) In: Animal Cell Bioreactors (Ho, C. S. and Wang, D. I. C., eds.), pp. 165-190, Butterworth-Heinemann, Stoneham
23. Griffiths, J.B., Cameron, D.R. and Looby, D. (1987) A comparison of unit process systems for anchorage dependent cells. Dev. Biol. Stand. 66, 331-338
24. Hamamoto, K., Ishimaru, K. and Tokashiki, M. (1989) Perfusion culture of hybridoma cells using a centrifuge to separate cells from culture mixture. J. Ferment. Bioeng. 67, 190-194
25. Hamamoto, K., Tokashiki, M. and Ichikawa, Y. (1985) Japanese patent Application, 60-224486
26. Hamamoto, K., Tokashiki, M., Ichikawa, Y. and Murakami, H. (1987) High cell density culture of a hybridoma using perfluorocarbon to supply oxygen. Agric. Biol. Chem. 51, 3415-3416
27. Handa-Corrigan, A. (1990) In: Animal Cell Biotechnology, Vol. 4 (Spier, R.E. and Griffiths, J.B., eds.), pp.123-132, Academic Press Ltd., London
28. Hayman, E.G., Ray, N.G. and Runstadler, Jr., P.W. (1987) In: Bioreactors and Biotransformations (Moody, G.W. and Baker, P. B., eds.), pp. 132-140, Elsevier, London, New York
29. Himmelfarb, P., Thayer, P.S. and Martin, H.E. (1969) Spin filter culture: The propagation of mammalian cells in suspension. Science 164, 555-557
30. Hopkinson, J. (1985) Hollow fiber cell culture systems for economical cell-product manufacturing. Bio/Technology 3, 225-230
31. Hosoi, S., Miyaji, H., Satoh, M., Kurimoto, T., Mihara, A., Fujiyoshi, N., Itoh, S. and Sato, S. (1991a) Optimization of cell culture conditions for production of biologically active proteins. Cytotechnology 5, SI7-34
32. Hosoi, S., Murosumi, K., Sasaki, K., Satoh, M., Miyaji, H., Hasegawa, M., Itoh, S., Tamaoki, T. and Sato, S. (1991b) Optimization of cell culture conditions for G-CSF (granulocytocolony stimulating factor) production by genetically engineered Namalwa KJM-1 cells. Cytotechnology 7, 25-32
33. Jacobs, M., Gummich, G., Keller, I. and Schwengers, D. (1991) In: Produdion of Biologicals from Animal Cells in Culture (Spier, R.E., Griffiths, J.B. and Meignier, B., eds.), pp. 439-442, Butterworth-Heinemann, Oxford
34. Jäger, V. (1992) In: Animal Cell Technology: Basic & Applied Aspects (Murakami, H., Shirahata, S. and Tachibana, H., eds.), pp. 209-216, Kluwer Academic Publishers, Dordrecht
35. Junker, B.H., Wu, F., Wang, S., Waterbury, J., Hunt, G., Hennessey, J., Aunins, J., Lewis, J., Silberklang, A. and Buckland, B.C. (1992) Evaluation of a microcarrier process for large-scale cultivation of attenuated hepatitis A. Cytotechnology 9, 173-187
36. Karkare, S.B., Phillips, P.G., Burke, D.H. and Dean, Jr., R.C. (1985) In: Large-Scale Mammalian Cell Culture (Feder, J. and Tolbert, W. R., eds.), pp. 127-149, Academic Press, Inc., Orlando
37. Katinger, A. and Scheirer, W. (1985) In: Animal Cell Biotechnology, Vol. 1 (Spier, R.E. and Griffiths, J.B., eds.), pp.167-193, Academic Press Inc. (London) Ltd
38. Kitano, K. (1991) In: Animal Cell Bioreactors (Ho, C.S. and Wang, D. I. C., eds.), pp. 73-106, Butterworth-Heinemann, Stoneham
39. Kitano, K., Ichimori, Y., Sawada, H., Iwasa, S., Sasai, S. and Tsukamoto, K. (1991) Effective production of anti-tetanus toxoid and anti-HBsAg human monoclonal antibodies by serum-free culture of hybridomas. Cytotechnology 5, S53-74
40. Kitano, K., Shintani, Y., Ichimori, Y., Tsukamoto, K., Sasai, S. and Kida, M. (1986) Production of human monoclonal antibodies by heterohybridomas. Appl. Microbiol. Biotechnol. 24, 282-286
41. Klement, G., Scheirer, W. and Katinger, H.W. D. (1987) Construction of a large-scale membrane reactor system with different compartments for cells, medium and product. Dev. Biol. Stand. 66, 221-226
42. Knazek, R. A., Gullino, P. M., Kohler, P. O. and Dedrick, R. L. (1972) Cell culture on artificial capillaries: An approach to tissue growth in vitro. Science 178, 65-67
43. Ku, K., Kuo, M. J., Delente, J., Wildi, B.S. and Feder, J. (1981) Development of a hollow-fiber system for large-scale culture of mammalian cells. Biotechnol. Bioeng. 23, 79-95
44. Lambert, K.J., Boraston, R., Thompson, P.W. and Birch, J.R. (1987) Production of monoclonal antibodies using large scale cell culture. Dev. Ind. Microbiol. 27, 101-106
45. Lazar, A., Reuveny, S., Muzrahi, A., Avtalion, M., Whiteside, J. P. and Spier, R.E. (1987) In: Modern Approaches to Animal Cell Technology (Spier, R.E. and Griffiths, J.B., eds.), pp. 437-448, Butterworth, Guildford
46. Lazar, A., Silberstein, L., Mizrahi, A. and Reuveny, S. (1988) An immobilized hybridoma culture perfusion system for production of monoclonal antibodies. Cytotechnology 1, 331-337
47. Lehmann, J., Vorlop, J. and Büntemeyer, H. (1988) In: Animal Cell Biotechnology, Vol. 3 (Spier, R.E. and Griffiths, J. B., eds.), pp. 221-237, Academic Press Ltd., London
48. Lim, F. and Sun, A.M. (1980) Microencapsulated islets as bioartificial endocrine pancreas. Science 21, 908-910
49. Looby, D. and Griffiths, J.B. (1987) In: Modern Approaches to Animal Cell Technology (Spier, R.E. and Griffiths, J.B., eds.), pp. 342-352, Butterworth, Guildford
50. Looby, D. and Griffiths, J.B. (1988) Fixed bed porous glass sphere (porosphere) bioreactors for animal cells. Cytotechnology 1, 339-346
51. Looby, D. and Griffiths, J.B. (1989) In: Advances in Animal Cell Biology and Technology for Bioprocesses (Spier, R.E., Griffiths, J.B., Stephenne, J. and Crooy, P. J., eds.), pp. 336-344, Butterworth, Guildford
52. Looby, D., Racher, A. J., Griffiths, J.B. and Dowsett, A.B. (1990) In: Physiology of Immobilized Cells (de Bont, J. A. M., Visser, J., Mattiason, B. and Tramper, J., eds.), pp. 255-264, Elsevier, Amsterdam
53. Lydersen, B.K., Pugh, G.G., Paris, M.S., Sharma, B.P. and Noll, L.A. (1985a) Ceramic matrix for large scale animal cell culture. Bio/Technology 3, 63-67
54. Lydersen, B.K., Putnam, J., Bognar, E., Patterson, M., Pugh, G.G. and Noll, L.A. (1985b) In: Large-Scale Mammalian Cell Culture (Feder, J. and Tolbert, W. R., eds.), pp. 39-58, Academic Press, Inc., Orlando
55. Matsushita, T., Ketayama M., Kamihata, K. and Funatsu, K. (1990) Anchorage-dependent mammalian cell culture using polyurethane foam as a new substratum for cell attachment. Appl. Microbiol. Biotechnol 33, 287-290
56. Mizrahi, A., Lazar, A. and Reuveny, S. (1990) In: Animal Cell Biotechnology, Vol. 4 (Spier, R.E. and Griffiths, J.B., eds.), pp. 413-444, Academic Press Ltd., London
57. Montagnon, B., Vincent-Falquet, J. C. and Fanget, Y. (1984) Thousand litre scale microcarrier culture of Vero cells for killed polio virus vaccine; promising results. Dev. Biol. Stand. 55, 37-42
58. Moo-Young, M. and Chisti, Y. (1988) Considerations for designing bioreactors for shearsensitive culture. Bio/Technology 6, 1291-1296
59. Murdin, A.D., Thorpe, J.S. and Spier, R.E. (1987) In: Modern Approaches to Animal Cell Technology (Spier, R.E. and Griffiths, J.B., eds.), pp. 420-436, Butterworth, Guildford
60. Nelson, K.L. (1988) Industrial-scale mammalian cell culture, part 1: Bioreactor design considerations. Biopharm. Manufact. Feb. 42-46
61. Nicholson, M.L., Hampson, B.S., Pugh, G.G. and Ho, C.S. (1991) In: Animal Cell Bioreactors (Ho, C.S. and Wang, D.I.C., eds.), pp. 269-303, Butterworth-Heinemann, Stoneham
62. Nilsson, K. and Mosbach, K. (1987) Immobilized animal cells. Dev. Biol. Stand. 66,183-193
63. Nilsson, K., Buzsaky, F. and Mosbach, K. (1986) Growth of anchorage-dependent cells on macroporous microcarriers. Bio/Technology 4, 989-990
64. Nilsson, K., Nilsson, L., Petterson, A.C. and Almgren, J. (1990) In: Trends in Animal Cell Culture Technology (Murakami, H., ed.), pp. 35-39, Kodansha Ltd., Tokyo
65. Nilsson, K., Scheirer, W., Merten, O.W., Ostberg, L., Liehl, E., Katinger, H.W.D. and Mosbach, K. (1983) Entrapment of animal cells for production of monoclonal antibodies and other biomolecules. Nature 302, 629-630
66. Ogata, M., Arikawa, K., Matsukura, H., Yamazaki, Y. and Suzuki, A. (1992) In: Animal Cell Technology: Basic and Applied Aspects (Murakami, H., Shirahata, S. and Tachibana, H., eds.), pp. 201-207, Kluwer Academic Publishers, Dordrecht
67. Phillips, A.W., Ball, G.D., Fantes, K.H., Finter, N.B. and Johnston, M.D. (1985) In: Large-Scale Mammalian Cell Culture (Feder, J. and Tolbert, W. R., eds.), pp. 87-95, Academic Press, Inc., Orlando
68. Posillico, E.G. (1986) Microencapsulation technology for large-scale antibody production. Bio/Technology 4, 114-117
69. Prokop, A. and Rosenberg, M.Z. (1989) In: Advances in Biochemical Engineering and Biotechnology, Vol. 39 (Fechter, A., ed.), pp. 29-71, Springer-Verlag, Berlin Heidelberg
70. Pugh, G.G., Berg, G.J. and Sear, C.H.J. (1987) In: Bioreactors and Biotransformations (Moody, G.W. and Baker, P.B., eds.), pp. 121-131, Elsevier, London
71. Pullen, A. F., Jonson, M.D., Phillips, A.W., Ball, G.D. and Finter, N.B. (1985) Very large scale suspension cultures of mammalian cells. Dev. Biol. Stand. 60, 175-177
72. Racher, A. J., Looby, D. and Griffiths, J. B. (1990) Studies on monoclonal antibody production by a hybridoma cell line (C1E3) immobilized in a fixed bed, porosphere culture system. J. Biotech. 15, 129-146
73. Ray, N.G., Tung, A.S., Runstadler, P.W. and Vournakis, J.N. (1991) In: Production of Biologicals from Animal Cells in Culture (Spier, R.E., Griffiths, J.B. and Meignier, B., eds.), pp. 502-512, Butterworth-Heinemann, Oxford
74. Rhodes, M. and Birch, J. (1988) Large-scale production of proteins from mammalian cells. Bio/Technology 6, 518-523
75. Rhodes, M., Gardiner, S. and Broad, D. (1991) In: Animal Cell Bioreactors (Ho, C.S. and Wang, D.I.C., eds), pp. 253-268, Butterworth-Heinemann, Stoneham
76. Runstadler, Jr., P.W. and Cernek, S.R. (1988) In: Animal Cell Biotechnology, Vol. 3 (Spier, R.E. and Griffiths, J.B., eds.), pp. 305-320, Academic Press Ltd., London
77. Runstadler, P.W., Ozturk, S.S. and Ray, N.G. (1992) In: Animal Cell Technology Basic & Applied Aspects (Murakami, H., Shirahata, S. and Tachibana, H., eds.), pp. 57-63, Kluwer Academic Publishers, Dordrecht
78. Rupp, R.G. (1985) In: Large-scale Mammalian Cell Culture (Feder, J. and Tolbert, W. R., eds.), pp.19-38, Academic Press, Inc., Orlando
79. Sato, S., Kawamura, K. and Fujiyoshi, N. (1983) Animal cell cultivation for production of biological substances with a novel perfusion culture apparatus. J. Tissue Culture Methods 8, 167-171
80. Sato, S., Kawamura, K., Hanai, N. and Fujiyoshi, N. (1985) In: Growth and Differentiation of Cells in Defined Environment (Murakami, H., Yamane, I., Barnes, D.W., Mather, J. P., Hayashi, I. and Sato, G.H., eds.), pp.123-126, Kodansha Ltd., Tokyo & Springer-Verlag, Hidelberg
81. Scheirer, W. (1988) In: Animal Cell Biotechnology, Vol. 3 (Spier, R.E. and Griffiths, J.B., eds.), pp. 263-281, Academic Press Ltd., London
82. Schönherr, O. T. and van Gelder, P. T. J. A. (1988) In: Animal Cell Biotechnology, Vol. 3 (Spier, R.E. and Griffiths, J.B., eds.), pp. 337-355, Academic Press Ltd., London
83. Shintani, Y., Kohno, Y., Sawada, H. and Kitano, K. (1991) Comparison of culture methods for human-human hybridomas secreting anti-HBsAg human monoclonal antibodies. Cytotechnology 6, 197-208
84. Shiragami, N., Ohira, Y. and Unno, H. (1991) In: Animal Cell Culture and Production of Biologicals (Sasaki, R. and Ikura, K., eds), pp. 121-126, Kluwer Academic Publishers, Dordrecht
85. Sinskey, A. J., Fleischaker, R. J., Tyo, M. A., Giard, D.J. and Wang, D. I. C. (1981) Production of cell-derived products: virus and interferon. Ann. N.Y. Acad. Sei. 369, 47-59
86. Spier, R.E. (1991) In: Animal Cell Culture and Production of Biologicals (Sasaki, R. and Ikura, K., eds.), pp. 41-46, Kluwer Academic Publishers, Dordrecht
87. Spier, R.E. and Griffiths, B. (1984) An examination of the data and concepts germane to the oxygenation of cultured animal cells. Dev. Biol. Stand. 55, 81-92
88. Spier, R.E. and Whiteside, J.P. (1976) The production of foot and mouth disease virus from BHK21C13 cells grown on the surface of glass spheres. Biotechnol. Bioeng. 18, 649-657
89. Spier, R.E. and Whiteside, J.P. (1984) The description of a device which facilitates the oxygenation of microcarrier cultures. Dev. Biol. Stand 55, 151-152
90. Spier, R.E. and Whiteside, J.P. (1990) In: Animal Cell Biotechnology, Vol. 4 (Spier, R.E. and Griffiths, J.B., eds.), pp. 133-148, Academic Press Ltd., London
91. Tharakan, J. P. and Chau, P. C. (1986a) A radial flow hollow fiber bioreactor for the large-scale culture of mammalian cells. Biotechnol. Bioeng. 28, 329-342
92. Tharakan, J. P. and Chau, P.C. (1986b) Operation and pressure distribution of immobilized cell hollow fiber bioreactors. Biotechnol. Bioeng. 28, 1064-1071
93. Tokashiki, M. (1991) In: Animal Cell Bioreactors (Ho, C. S. and Wang, D. I. C., eds.), pp. 327-356, Butterworth-Heinemann, Stoneham
94. Tokashiki, M. and Arai, T. (1989) High density culture of mouse-human hybridoma cells using a perfusion culture apparatus with multi-settling zones to separate cells from the culture medium. Cytotechnology 2, 5-8
95. Tokashiki, M. and Arai, T. (1991) In: Production of Biologicals from Animal Cells in Culture (Spier, R.E., Griffiths, J.B. and Meignier, B., eds.), pp. 467-469, Butterworth-Heinemann, Oxford
96. Tokashiki, M., Arai, T., Hamamoto, K. and Ishimaru, K. (1990) High density culture of hybridoma cells using a perfusion culture vessel with an external centrifuge. Cytotechnology 3, 239-244
97. Tokashiki, M., Hamamoto, K., Takazawa, Y. and Ichikawa, Y. (1988) High-density culture of mouse-human hybridoma cells using a new perfusion culture vessel. Kagakukogaku Ronbun-shu 14, 337-341
98. Tolbert, W. R. and Feder, J. (1983) In: Annual Reports on Fermentation Processes, Vol. 6 (Tsao, G.T., Flickinger, M.C. and Finn, R.K., eds.), pp. 35-74, Academic Press, Inc., New York
99. Tolbert, W.R., Lewis, C., White, P.J. and Feder, J. (1985) In: Large-Scale Mammalian Cell Culture (Feder, J. and Tolbert, W. R., eds.), pp. 97-123, Academic Press, Inc., Orlando
100. Tolbert, W.R., Srigley, W.R. and Prior, C.P. (1988) In: Animal Cell Biotechnology, Vol. 3 (Spier, R.E. and Griffiths, J.B., eds.), pp. 373-393, Academic Press Ltd., London
101. Tyo, M.A., Bulbulian, B.J., Menken, B.Z. and Murphy, T.J. (1988) In: Animal Cell Biotechnology, Vol. 3 (Spier, R.E. and Griffiths, J.B., eds.), pp. 357-371, Academic Press Ltd., London
102. van Wezel, A. L. (1967) Growth of cell-strains and primary cells on micro-carriers in homogeneous culture. Nature 216, 64-65
103. van Wezel, A.L. (1985) In: Animal Cell Biotechnology, Vol. 1 (Spier, R.E. and Griffiths, J.B., eds.), pp. 265-282, Academic Press Inc. (London) Ltd
104. Vournakis, J.N. and Runstadler, Jr., P.W. (1991) In: Animal Cell Bioreactors (Ho, C.S. and Wang, D.I.C., eds.), pp. 305-326, Butterworth-Heinemann, Stoneham
105. Whiteside, J.P. and Spier, R.E. (1981) The scale-up from 0.1 to 100 litres of a unit process system based on 3 mm diameter glass spheres for the production of four strains of FMDV from BHK monolayer cells. Biotechnol. Bioeng. 23, 551-565
106. Yamaji, H. and Fukuda, H. (1991) Long-term cultivation of anchorage-independent animal cells immobilized within reticulated biomass support particles in a circulating bed fermentor. Appl. Microbiol. Biotechnol. 34, 730-734
107. Yoshida, H., Mizutani, S. and Ikenaga, H. (1991) In: Animal Cell Culture and Production of Biologicals (Sasaki, R. and Ikura, K., eds.), pp. 329-334, Kluwer Academic Publishers, Dordrecht