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Volumn 39, Issue 1, 1999, Pages 36-45

Design and diversity analysis of large combinatorial libraries using cell-based methods

Author keywords

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Indexed keywords


EID: 0001923937     PISSN: 00952338     EISSN: None     Source Type: Journal    
DOI: 10.1021/ci980138p     Document Type: Article
Times cited : (52)

References (24)
  • 1
    • 0030815955 scopus 로고    scopus 로고
    • Designing combinatorial library mixtures using a genetic Algorithm
    • Brown, R. D.; Martin, Y. C. Designing Combinatorial Library Mixtures Using a Genetic Algorithm. J. Med. Chem. 1997, 40, 2304-2313.
    • (1997) J. Med. Chem. , vol.40 , pp. 2304-2313
    • Brown, R.D.1    Martin, Y.C.2
  • 2
    • 0030341922 scopus 로고    scopus 로고
    • The measurement of molecular diversity: A three-dimensional approach
    • Chapman, D. The Measurement of Molecular Diversity: A Three-Dimensional Approach. J. Comput.-Aided Mol. Des. 1996, 10, 501-512.
    • (1996) J. Comput.-Aided Mol. Des. , vol.10 , pp. 501-512
    • Chapman, D.1
  • 3
    • 0031152087 scopus 로고    scopus 로고
    • Combinatorial approaches for library design and molecular diversity
    • Blaney, J. M.; Martin, E. J. Combinatorial Approaches for Library Design and Molecular Diversity. Curr. Opin. Chem. Biol. 1997, 7, 54-59.
    • (1997) Curr. Opin. Chem. Biol. , vol.7 , pp. 54-59
    • Blaney, J.M.1    Martin, E.J.2
  • 4
    • 0028953765 scopus 로고
    • Measuring diversity: Experimental design of combinatorial libraries for drug discovery
    • Martin, E. J.; Blaney, J. M.; Siani, M. A.; Spellmeyer, D. C.; Wong. A. K.; Moos, W. H. Measuring Diversity: Experimental Design of Combinatorial Libraries for Drug Discovery. J. Med. Chem. 1995, 38, 1431-1436.
    • (1995) J. Med. Chem. , vol.38 , pp. 1431-1436
    • Martin, E.J.1    Blaney, J.M.2    Siani, M.A.3    Spellmeyer, D.C.4    Wong, A.K.5    Moos, W.H.6
  • 5
    • 0030831365 scopus 로고    scopus 로고
    • New methodology for profiling combinatorial libraries and screening sets: Cleaning up the design process with HARPick
    • Good, A C.; Lewis, R. A. New Methodology for Profiling Combinatorial Libraries and Screening Sets: Cleaning Up the Design Process with HARPick. J. Med. Chem. 1997, 40, 3926-3936.
    • (1997) J. Med. Chem. , vol.40 , pp. 3926-3936
    • Good, A.C.1    Lewis, R.A.2
  • 6
    • 0000465937 scopus 로고    scopus 로고
    • Diversity profiling and design using 3D pharmacophores: Pharmacophore-derived queries (PDQ)
    • Pickett, S. D.; Mason, J. S.; McLay, I. M. Diversity Profiling and Design Using 3D Pharmacophores: Pharmacophore-Derived Queries (PDQ). J. Chem. Inf. Comput. Sci. 1996, 1214-1223.
    • (1996) J. Chem. Inf. Comput. Sci. , pp. 1214-1223
    • Pickett, S.D.1    Mason, J.S.2    McLay, I.M.3
  • 7
    • 0030252451 scopus 로고    scopus 로고
    • Optimization and visualization of molecular diversity of combinatorial libraries
    • Hassan, M.; Bielawski, J. P.; Hempel, J. C.; Waldman, M. Optimization and Visualization of Molecular Diversity of Combinatorial Libraries. AM. Diversity 1996, 2, 64-74.
    • (1996) AM. Diversity , vol.2 , pp. 64-74
    • Hassan, M.1    Bielawski, J.P.2    Hempel, J.C.3    Waldman, M.4
  • 9
    • 0000191614 scopus 로고    scopus 로고
    • Stochastic algorithms for maximizing molecular diversity
    • Agrafiotis, D. M. Stochastic Algorithms for Maximizing Molecular Diversity. J. Chem. Inf. Comput. Sci. 1997, 37, 841-851.
    • (1997) J. Chem. Inf. Comput. Sci. , vol.37 , pp. 841-851
    • Agrafiotis, D.M.1
  • 10
    • 85034536859 scopus 로고    scopus 로고
    • Tripos Associates: Selector; Chemical Design: Chem-Diverse
    • For example, Molecular Simulations: Cerius2 Diversity Manager, Tripos Associates: Selector; Chemical Design: Chem-Diverse.
    • Molecular Simulations: Cerius2 Diversity Manager
  • 11
    • 0031077897 scopus 로고    scopus 로고
    • Drug-motif based diverse monomer selection: Method and application in combinatorial chemistry
    • Lewell, X. Q.; Smith, R. Drug-motif Based Diverse Monomer selection: Method and Application in Combinatorial Chemistry. J. Mol. Graphics Model. 1997, 15, 43-48.
    • (1997) J. Mol. Graphics Model. , vol.15 , pp. 43-48
    • Lewell, X.Q.1    Smith, R.2
  • 12
    • 0031232007 scopus 로고    scopus 로고
    • Optimum utilization of a compound collection or chemical library for drug discovery
    • Young, S. S.; Sheffield, C. F.; Farmen, M. Optimum Utilization of a Compound Collection or Chemical Library for Drug Discovery. J. Chem. Inf. Comput. Sci. 1997, 37, 892-899.
    • (1997) J. Chem. Inf. Comput. Sci. , vol.37 , pp. 892-899
    • Young, S.S.1    Sheffield, C.F.2    Farmen, M.3
  • 13
    • 0031232030 scopus 로고    scopus 로고
    • Experimental designs for selecting molecules form large chemical databases
    • Higgs, R. E.; Bemis, K. G.; Watson, I. A.; Wikel, J. H. Experimental Designs for Selecting Molecules form Large Chemical Databases. J. Chem. Inf. Comput. Sci. 1997, 37, 861-870.
    • (1997) J. Chem. Inf. Comput. Sci. , vol.37 , pp. 861-870
    • Higgs, R.E.1    Bemis, K.G.2    Watson, I.A.3    Wikel, J.H.4
  • 14
    • 0030943408 scopus 로고    scopus 로고
    • Selecting optimally diverse compounds from structure databases: A validation study of two-dimensional and three-dimensional molecular descriptors
    • Matter, H. Selecting Optimally Diverse Compounds from Structure Databases: A Validation Study of Two-Dimensional and Three-Dimensional Molecular Descriptors. J. Med. Chem. 1997, 40, 1219-1229.
    • (1997) J. Med. Chem. , vol.40 , pp. 1219-1229
    • Matter, H.1
  • 16
    • 0000528756 scopus 로고    scopus 로고
    • The effectiveness of reactant pools for generating structurally- Diverse combinatorial libraries
    • Gillet, V. J.; Willett, P.; Bradshaw, J. The Effectiveness of Reactant Pools for Generating Structurally- Diverse Combinatorial Libraries. J. Chem. Inf. Comput. Sci. 1997, 37, 731-740.
    • (1997) J. Chem. Inf. Comput. Sci. , vol.37 , pp. 731-740
    • Gillet, V.J.1    Willett, P.2    Bradshaw, J.3
  • 17
    • 0003230848 scopus 로고    scopus 로고
    • Novel software tools for addressing chemical diversity
    • Pearlman, R. S. Novel Software Tools for Addressing Chemical Diversity. Network Science', 1996; http://www.awod.com/netsci/Science/combichem/feature08.html.
    • (1996) Network Science'
    • Pearlman, R.S.1
  • 18
    • 84954610895 scopus 로고
    • Experimental design in synthesis planning and structure property correlations
    • Austel V. Experimental Design in Synthesis Planning and Structure Property Correlations. Methods Principles Med. Chem. 1995, 2, 49-62.
    • (1995) Methods Principles Med. Chem. , vol.2 , pp. 49-62
    • Austel, V.1
  • 19
    • 0004117253 scopus 로고    scopus 로고
    • Daylight Chemical Information, Inc., 18500 Von Karman #450, Irvine, CA
    • Daylight Chemical Information Software, ver 4.51; Daylight Chemical Information, Inc., 18500 Von Karman #450, Irvine, CA.
    • Daylight Chemical Information Software, Ver 4.51
  • 20
    • 85034534902 scopus 로고    scopus 로고
    • eduSoft, P.O. Box 1811, Ashland VA 23005
    • MOLCONNZ ver3. 10S; eduSoft, P.O. Box 1811, Ashland VA 23005.
    • MOLCONNZ Ver3. 10S
  • 21
    • 85034551003 scopus 로고    scopus 로고
    • Creative Arts Bldg. 181, Indiana University, Bloomington, IN
    • MOPAC93; QCPE, Creative Arts Bldg. 181, Indiana University, Bloomington, IN.
    • MOPAC93; QCPE
  • 22
    • 85034530657 scopus 로고    scopus 로고
    • Tripos Associates, 1699 South Hanley, St. Louis, MO
    • Sybyl6.3; Tripos Associates, 1699 South Hanley, St. Louis, MO.
    • Sybyl6.3
  • 23
    • 85034556349 scopus 로고    scopus 로고
    • Molecular Simulations, Inc., 9685 Scranton Rd., San Diego, CA
    • Cerius2 ver 3.0; Molecular Simulations, Inc., 9685 Scranton Rd., San Diego, CA.
    • Cerius2 Ver 3.0
  • 24
    • 85034558446 scopus 로고    scopus 로고
    • Mathworks, Inc., 24 Prime Park Wat, Natlick, MA
    • MATLAB ver4; Mathworks, Inc., 24 Prime Park Wat, Natlick, MA.
    • MATLAB Ver4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.