Oral Limonene: Combined Prenylation Inhibitor Therapy of Cancer

Journal of Medicinal Food

Volumn 1, Issue 2, 1998, Pages 83-88

  Nagourney, Robert A ^a  

^a Rational Therapeutics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001921354     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.1998.1.83     Document Type: Article

References (18)

1. Chander, S. K., Lansdown, A. G., Luqmani, Y. A., Gomm, J. J., Gould, M. N., and Coombes, R. C. (1994). Effectiveness of combined limonene and 4-hydroxyandrostenedione in the treatment of NMU-induced rat mammary tumours. Br J Cancer 69, 879–882.
2. Crowell, P. L., Cang, R. R., Ren, Z., Elson, C. E., and Gould, M. N. (1991). Selective inhibition of isoprenylation of 21–26-kDa proteins by the anticarcinogen d-limonene and its metabolites. J Biol Chem 266,17679–17685.
3. Crowell, P. L., Lin, S., Vedejes, E., and Gould, M. N. (1992). Identification of metabolites of the antitumor agent d-limonene capable of inhibiting protein isoprenylation and cell growth. Cancer Chemother Pharmacol 31, 205–212.
4. Elegbede, J. A., Elson, C. E., Quereshi, A., Tanner, M. A., and Gould, M. N. (1984). Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene. Carcinogenesis 5, 661–664.
5. Elegbede, J. A., Maltzman, T. H., Elson, C. E., and Gould, M. N. (1993). Effects of anticarcinogenic monoterpenes on Phase II hepatic metabolizing enzymes. Carcinogenesis 14,1221–1223.
6. Haag, J. D., Lindstrom, M. J., and Gould, M. N. (1992). Limonene-induced regression of mammary carcinomas. Cancer Res 52, 4021–4026.
7. Hohl, R. J. (1996). Monoterpenes as regulators of malignant cell proliferation. Adv Experi Med Biol 401,137–146.
8. Hohl, R. J., and Lewis, K. (1995). Differential effects of monoterpenes and lovastatin on ras processing. J Biol Chem 270,17508–17512.
9. Homburger, F., Treger, A., and Boger, E. (1971). Inhibition of murine subcutaneous and intravenous benzo-(rst)pentaphene carcinogenesis by sweet orange oils and d-limonene. Oncology 25,1–10.
10. Karlson, J., Borg-Karlson, A. K., Unelius, R., Shoshan, M. C., Wilking, N., Ringborg, U., and Linder, S. (1996). Inhibitions of tumor cell growth by monoterpenes in vitro: Evidence of a ras-independent mechanism of action. Anti-Cancer Drugs 7, 422–429.
11. Lowy, D. R., and Willumsen, B. M. (1993). Function and regulation of ras. Ann Rev Biochem 62, 851–891.
12. McNamee, D. (1993). Limonene trial in cancer. Lancet 342, 801.
13. Mills, J. J., Chari, R. S., Boyer, I. J., Gould, M. N., and Jirtle, R. L. (1995). Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. Cancer Res 55,979–983.
14. Nagourney, R. A. (1997). Combined prenylation inhibitor therapy in drug refractory cancers. Proc Am Soc Clin Oncol Abs, 16:1863.
15. Poon, G. K., Vigushin, D., Griggs, L. J., Rowlands, M. G., Coombes, R. C., and Jarman, M. (1996). Identification and characterization of limonene metabolites in patients with advanced cancer by liquid chromatography/mass spectrometry. Drug Metabol Disposition 24, 565–571.
16. Schafer, W. R., Kim, R., Sterne, R., Thorner, J., Kim, S. H., and Rine, J. (1989). Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans. Science 245, 379–385.
17. Von Burg, R. (1995). Limonene [Review]. J Appi Toxicol 15, 495–499.
18. Wattenberg, L. W., and Coccia, J. B. (1991). Inhibition of 4-(methylnitrosamino)-1-butanone carcinogenesis in mice by d-limonene and citrus fruit oils. Carcinogenesis 12,115–117.