Marine biodiversity and the medicine cabinet the status of new drugs from marine organisms

Oceanography

Volumn 9, Issue SPL.ISS. 1, 1996, Pages 23-27

  Fenical, William ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001839997     PISSN: 10428275     EISSN: None     Source Type: Journal    
DOI: 10.5670/oceanog.1996.23     Document Type: Article

References (14)

1. de Silva, E.D. and P.J. Scheuer, 1980: Manoalide, an antibiotic sesterterpenoid from the marine sponge Luffariella variabilis. Tetrahedrom Lett., 21, 1611-1614.
2. Gerwick, W.H., P.J. Protean, D.G. Nagle, E. Hamel, A. Blotchin and D.L. Slate, 1994: Structure of curacin A, a novel antimitotic, antiproliferative, and brine shrimp toxic natural product from the marine cyanobacterium Lyngbya majuscula. J. Org. Chem., 59, 1243-1245.
3. Gunasekera, S.P., M. Gunasekera and G.K. Schulte, 1990: Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta. J. Org. Chem., 55, 4912-4915. erratum. 1991. J. Org. Chem., 56, 1346.
4. Hay, M.E. and W. Fenical, 1996: Chemical ecology and marine biodiversity: insights and products from the sea. Oceanography, 9, 10-20.
5. Hirata, Y. and D. Uemura, 1986: Halichondrins-- antitumor polyether macrolides from a marine sponge. Pure Appl. Chem., 58, 701-710.
6. Look, S.A., W. Fenical, R.S. Jacobs and J. Clardy, 1986: The pseudopterosins; antiinflammatory and analgesic natural products from sea whip Pseudopterogorgia elisabethae. Proc. Natl. Acad. Sci. USA, 83, 6238-6240.
7. Penit, G.R., C.L. Herald, D.L. Doubek, D.L. Herald, E. Arnold and J. Clardy, 1982: Isolation and structure of bryostatin 1. J. Am. Chem. Soc., 104, 6846-6848.
8. Penit, G.R., Y. Kamano, C.L. Herald, A.A. Tuinman, F.E. Boettner, H. Kizu, J.M. Schmidt, L. Baczynskyj, K.B. Tomer and R.J. Bontems, 1987: Isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10. J. Am. Chem. Soc., 109, 6883-6885.
9. Potts, B.C.M., D.J. Faulkner, M.S. de Carvalho and R.S. Jacobs, 1992: Chemical mechanism of inactivation of bee venom phospholipase At by the natural products manoalide, luffariellolide and scalaradiol. J. Am. Chem. Soc., 114, 5093-5101.
10. Rinehart, K.L., Jr., J.B. Gloer, J.C. Cook, S.A. Mizsak and T.A. Scahill, 1981: Structures of the didemnins; antiviral and cytotoxic depsipeptides from a Caribbean tunicate. J. Am. Chem. Soc., 103, 1857-1859.
11. Rinehart, K.L., Jr., T.G. Holt, N.L. Fregeau, J.G. Stroh, P.A. Keifer, F. Sun, L.H. Li and D.G. Martin, 1990: Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata. J. Org. Chem., 55, 4512-4515.
12. Suffness, M., D.J. Newmann and K. Shader, 1989: Discovery and development of antineoplastic agents from natural sources. In: Bioorganic Chemisto, vol. 3. P.J. Scheuer, ed. Springer-Verlag, New York, 131-168.
13. ter Haar, E., R.J. Kowalski, E. Hamel, C.M. Lin, R.E. Longley, S. Gunasekera, H.S. Rosenkranz and B.W. Day, 1996: Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. Biochemistry, 35, 243-245.
14. Wright, A.E., D.A. Forleo, G.P. Gunawardana, S.P. Gunasekera, F.E. Koehn and O.J. Mc-Connell, 1990: Antitumor tetrahydroisoquinoline alkaloids from the colonial ascid-Jan Ecteinascidia mrbinata. J. Org. Chem., 55, 4508-4512.