A tandem Horner-Emmons olefination-gonjugate addition approach to the synthesis of 1,5-Disubstituted-6-azabicyclo[3.2.1]octanes based on the AE ring structure of the norditerpenoid alkaloid methyllycaconitine

Journal of Organic Chemistry

Volumn 61, Issue 14, 1996, Pages 4634-4640

  Callis, David J ^a   Thomas, Noel F ^a   Pearson, David P J ^b   Potter, Barry V L ^a  

^a University of Bath   (United Kingdom)

^b JEALOTT S HILL RESEARCH STATION   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001732459     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9519672     Document Type: Article

References (44)

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2. For azabicyclo[3.2.1]octanes, see: (a) Lounasmaa, M. The Alkaloids; Academic Press Inc.: New York, 1988; Vol. 33, pp 1-83. (b) Focor, G.; Dharanipragada, R. Nat. Prod. Rep. 1990, 7, 539. (c) Turconi, M.; Nicola, M.; Quintero, M. G.; Maiocchi, L.; Micheletti, R.; Geraldo, E.; Donetti, A. J. Med. Chem. 1990, 33, 2101. (d) Jung, M. E.; Longmei, Z.; Tangsheng, P.; Huiyan, Z.; Yan, L.; Jingyu, S. J. Org. Chem. 1992, 57, 3528. (e) Petersen, J. S.; Toteberg-Kaulen, S.; Rapoport, H. J. Org. Chem. 1984, 49, 2948. (f) Fevig, J. M.; Marquis, R. W.; Overman, L. E. J. Am. Chem. Soc. 1991, 113, 5085.
3. For azabicyclo[3.2.1]octanes, see: (a) Lounasmaa, M. The Alkaloids; Academic Press Inc.: New York, 1988; Vol. 33, pp 1-83. (b) Focor, G.; Dharanipragada, R. Nat. Prod. Rep. 1990, 7, 539. (c) Turconi, M.; Nicola, M.; Quintero, M. G.; Maiocchi, L.; Micheletti, R.; Geraldo, E.; Donetti, A. J. Med. Chem. 1990, 33, 2101. (d) Jung, M. E.; Longmei, Z.; Tangsheng, P.; Huiyan, Z.; Yan, L.; Jingyu, S. J. Org. Chem. 1992, 57, 3528. (e) Petersen, J. S.; Toteberg-Kaulen, S.; Rapoport, H. J. Org. Chem. 1984, 49, 2948. (f) Fevig, J. M.; Marquis, R. W.; Overman, L. E. J. Am. Chem. Soc. 1991, 113, 5085.
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