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Preliminary trials of coupling reaction using DCC and DCC/ HOBt in the presence of triethylamine as tertiary base were carried out. Nevertheless, yields in the condensation step were very poor and these methods were abandoned.
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25
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4243101019
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note
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Dabco is a tertiary base of known high basicity characteristics and low steric interference on the bridghead nitrogen atom whose systematical application in amino acid derivatives and peptide synthesis has not been reported yet.
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α-acyl-L-arginine residue and one unreacted amino group from the alkyldiamine were formed.
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31
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4243105462
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Characterization of these interesting liquid crystalline phases is in progress in collaboration with other research groups, by means of several techniques, including X-ray diffraction.The results will be reported in the near future.
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