Phototherapy for Neonatal Jaundice. Configurational Isomers of Bilirubin

Journal of the American Chemical Society

Volumn 104, Issue 24, 1982, Pages 6865-6867

  McDonagh, Antony F ^a   Palma, Lucita A ^a   Trull, Francesc R ^b   Lightner, David A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NEVADA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0001614291     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja00388a103     Document Type: Article

References (29)

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16. Rapid configurational photoisomerization of Z,Z-1 occurs in organic and aqueous albumin solutions. In water, disproportionation to IIIα and XIIIα structural isomers occurs (see: McDonagh, A. F., Ann. N.Y. Acad. Sci. 1975, 244, 553–569), and Z → E isomerization is undetectable.
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23. 19 Peak 1 was not identified, peak 2 was attributed to E,E-1, and peak 3 was attributed to a mixture of the two E, Z isomers of 1. On the basis of data described in this and the following communication, it is clear that peak 2 is not E,E-1 and probable that peak 3 is almost exclusively 4Z,15E-1.
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29. 1H NMR spectral analysis of the mixture of 4Z,15Z-1 and 4E,15E-1 obtained by anaerobic irradiation of 4Z,15Z-1 (Falk, H.; Müller, N.; Ratzenhofer, M.; Winsauer, K. Monatsh. Chem.). In this work the authors also converted the mixture of E isomers of 1 to the corresponding, previously characterized, 4Z,15E and 4E,15Z biliverdins IXα, thus providing independent confirmation of the structural assignments made in the present communication.