Olfactory receptors: A large gene family with broad affinities and multiple functions

Neuroscientist

Volumn 2, Issue 5, 1996, Pages 262-271

  Shepherd, Gordon M ^a   Singer, Michael S ^a   Greer, Charles A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Correlated mutation analysis; G protein coupled receptor; Molecular model; Odor transduction; Olfactory bulb; Olfactory epithelium

Indexed keywords

EID: 0001612419     PISSN: 10738584     EISSN: None     Source Type: Journal    
DOI: 10.1177/107385849600200512     Document Type: Review

References (64)

1. Pace U, Hansky E, Salomon Y, Lancet D. Odorant sensitive adenylate cyclase may mediate olfactory reception. Nature 1985; 316:255-258.
2. Shepherd GM. Welcome whiff of biochemistry. Nature 1985;316: 214-215.
3. Nakamura T, Gold GH. A cyclic nucleotide-gated conductance in olfactory receptor cila. Nature 1987;325:442-444.
4. Reed R. Signaling pathways in odorant detection. Neuron 1992; 8:205-209.
5. Lancet D. Vertebrate olfactory reception. Annu Rev Neurosci 1986;9:329-355.
6. Buck L, Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odorant recognition. Cell 1991; 65:175-187.
7. Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M. Olfactory receptors are displayed on dog mature sperm cells. J Cell Biol 1993;123:1441-1452.
8. Drutel G, Arrang J-M, Diaz J, Wisnewsky C, Schwartz K, Schwartz J-C. Cloning of OL1, a putative olfactory receptor and its expression in the developing rat heart. Receptors Channels 1995;3:33-40.
9. Ngai J, Chess A, Dowling MM, Necles N, Macagno ER, Axel R. Coding of Olfactory information: topography of odorant receptor expression in the catfish olfactory epithelium. Cell 1993;72:667-680.
10. Chess A, Simon I, Cedar H, Axel R. Allelic inactivation regulates olfactory receptor gene expression. Cell 1994;78:823-834.
11. Zhao H, Dibello P, Carlson J, Firestein S. PCR amplification of odor receptor cDNA from individual olfactory neurons in salamander. Chem Senses 1994;19:579-580.
12. Rawson NE, Restrepo D. Does a single olfactory neuron express one or more receptor genes? Soc Neurosci Abstr 1995;21:131.
13. Raming K, Krieger J, Strotmann J, et al. Cloning and expression of odorant receptors. Nature 1993;361:353-356.
14. Sklar PB, Anholt RRH, Snyder SH. The odorant-sensitive adenylate cyclase of olfactory receptor cells: differential stimulation by distinct classes of odorants. J Biol Chem 1986;261:15538-15543.
15. Firestein S, Darrow B, Shepherd GM. Activation of the sensory current in salamander olfactory receptor neurons depends on a G protein-mediated cAMP second messenger system. Neuron 1991; 6:825-835.
16. Kurihashi T, Kaneko A. High density cAMP-gated channels at the ciliary membrane in the olfactory receptor cell. Neuroreport 1991; 2:5-8.
17. Ache B. Towards a common strategy for transducing olfactory information. Semin Cell Biol 1994;5:55-64.
18. Weth F, Baier H, Korsching S. Modules for molecules? Topographical organization of the zebrafish olfactory system. Soc Neurosci Abstr 1995;21:1995.
19. Vogt RG, Byrd CA, Sun M. Bilateral asymmetry of odor receptor gene expression in embryonic zebrafish (Danio rerio). Soc Neurosci Abstr 1995;21:130.
20. Nef P, Hermans-Borgmeyer I, Artières-Pin H, Beasley L, Dionne VE, Heinemann SF. Spatial pattern of receptor expression in the olfactory epithelium. Proc Natl Acad Sci U S A 1992;89:8948-8952.
21. Ressler KJ, Sullivan SL, Buck LB. A zonal organization of odorant receptor gene expression in the olfactory epithelium. Cell 1993;73:597-609.
22. Vassar R, Ngai J, Axel R. Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell 1993;74: 309-318.
23. Strotmann J, Wanner I, Helfrich T, et al. Olfactory neurones expressing distinct odorant receptor subtypes are spatially segregated in the nasal neuroepithelium. Cell Tissue Res 1994;276:429-438.
24. Strotmann J, Wanner I, Krieger J, Raming K, Breer H. Expression of odorant receptors in spatially restricted subsets of chemosensory neurones. Neuroreport 1992;3:1053-1056.
25. Vassar R, Chou SK, Sitcheran R, Nuñez JM, Vosshall LB, Axel R. Topographic organization of sensory projections to the olfactory bulb. Cell 1994;79:981-991.
26. Ressler KJ, Sullivan SL, Buck LB. Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell 1994;79:1245-1255.
27. Axel R. The molecular logic of smell. Sci Am 1995;273:154-159.
28. Stewart WB, Kauer JS, Shepherd GM. Functional organization of rat olfactory bulb analysed by the 2-deoxyglucose method. J Comp Neurol 1979;185:715-734.
29. Lancet D, Greer CA, Kauer JS, Shepherd GM. Mapping of odor-related neuronal activity in the olfactory bulb by high-resolution 2-deoxyglucose autoradiography. Proc Natl Acad Sci U S A 1982; 79:670-674.
30. Greer CA, Stewart WB, Teicher MH, Shepherd GM. Functional development of the olfactory bulb and a unique glomerular complex in the neonatal rat. J Neurosci 1982;2:1744-1759.
31. Astic L, Saucier D. Anatomical mapping of the neuroepithelial projection to the olfactory bulb in the rat. Brain Res Bull 1986; 16:445-454.
32. Pedersen PE, Jastreboff PJ, Stewart WB, Shepherd GM. Mapping of an olfactory receptor population that projects to a specific region in the rat olfactory bulb. J Comp Neurol 1986;250:93-108.
33. Schoenfeld TA, Clancy AN, Forbes WB, Macrides F. The spatial organization of the peripheral olfactory system of the hamster. I. Receptor neuron projections to the main olfactory bulb. Brain Res Bull 1994;34:183-210.
34. Hirsch JD, Margolis FL. Isolation, separation, and analysis of cells from olfactory epithelium. In: Cagan RH, Kare MR, editors. Biochemistry of taste and olfaction. New York: Academic Press 1981; 311-332.
35. Hedlund B, Shepherd GM. Biochemical studies on muscarinic receptors in the salamander olfactory epithelium. FEBS Lett 1983; 162:428-31.
36. Shepherd GM, Hedlund B. Muscarinic receptor-olfactory receptor interactions in the salamander olfactory epithelium. Soc Neurosci Abstr 1983;9:463.
37. Firestein S, Shepherd GM. Neurotransmitter antagonists block some odor responses in olfactory receptor neurons. Neuroreport 1992;3:661-664.
38. Boekhoff I, Tareilus E, Strottmann J, Breer H. Rapid activation of alternative second messenger pathways in olfactory cilia from rats by different odorants. EMBO J 1990;9:2453-2458.
39. Breer H, Boekhoff I, Tareilus E. Rapid kinetics of second messenger formation in olfactory transduction. Nature 1990;345:65-68.
40. Strader CD, Sigal IS, Dixon RAF. Structural basis of β-adrenergic receptor function. FASEB J 1989;3:1825-1832.
41. Tota MR, Strader CD. Characterization of the binding domain of the beta-adrenergic receptor with the fluorescent antagonist carazolol. Evidence for a buried ligand binding site. J Biol Chem 1990;265:16891-16897.
42. Hibert MF, Trumpp-Kallmeyer S, Briunvels A, Hoflack J. Three-dimensional models of neurotransmitter G-binding protein-coupled receptors. Mol Pharmacol 1991;40:8-15.
43. Schwartz T. Locating ligand-binding sites in 7-TM receptors by protein engineering. Curr Opinion Biotechnol 1994;5:334-344.
44. Singer MS, Shepherd GM. Molecular modeling of ligand-receptor interactions in the OR5 olfactory receptor. Neuroreport 1994;5: 1297-1300.
45. Henderson R, Baldwin JM, Ceska TA, Zemlin F, Beckmann E, Downing KH. Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy. Mol Biol 1990;213: 899-929.
46. Unger VM, Schertler GF. Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy. Biophys J 1995; 68:1776-1786.
47. Strader CD, Fong TM, Graziano MP, Tota MR. The family of G-protein-coupled receptors. FASEB J 1995;9:745-754.
48. Bajgrowicz J, Broger C. Molecular modeling in design of new odorants: scope and limitations. In: KHC Baser, editor. Flavours, fragrances and essential oils. Proceedings of the 13th International Congress of Flavours, Frangrances and Essential Oils. Istanbul: AREP Publishing 1995.
49. Oliveira L, Paiva ACM, Vriend G. A common motif in G-protein-coupled seven transmembrane helix receptors. J Comput Aided Mol Des 1993;7:649-658.
50. Kuipers W, Oliveira L, Paiva ACM, et al. Analysis of G protein-coupled receptor function. In: Findlay J, editor. Membrane protein models: experiment, theory, and speculation. Oxford: BIOS; in press.
51. Singer MS, Oliveira L, Vriend G, Shepherd GM. Potential ligand-binding residues in rat olfactory receptors identified by correlated mutation analysis. Receptors Channels 1995;3:89-95.
52. Göbel U, Sander C, Schneider R, Valencia A. Correlated mutations and residue contacts in proteins. Proteins 1994;18:309-317.
53. Gregoret LM, Sauer RT. Additivity of mutant effects assessed by binomial mutagenesis. Proc Natl Acad Sci U S A 1993;90:4246-4250.
54. Neher E. How frequent are correlated changes in families of protein sequences? Proc Natl Acad Sci U S A 1994;91:98-102.
55. 3 muscarinic receptor: identification of a series of threonine and tyrosine residues involved in agonist but not antagonist binding. EMBO J 1991;10:3729-3734.
56. Strader CD, Fong TM, Tota MR, Underwood D, Dixon R. Structure and function of G protein-coupled receptors. Annu Rev Biochem 1994;63:101-132.
57. Hughes AL, Nei M. Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection. Nature 1988;335:167-170.
58. Hughes AL, Nei M. Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection. Proc Natl Acad Sci U S A 1989;86:958-962.
59. Ngai J, Dowling MM, Buck L, Axel R, Chess A. The family of genes encoding odorant receptors in the channel catfish. Cell 1993;72:657-666.
60. Lancet D, Sadovsky E, Seidemann E. Probability model for molecular recognition in biological receptor repertoires: significance to the olfactory system. Proc Natl Acad Sci U S A 1993;90:3715-3719.
61. Ben-Arie N, Lancet D, Taylor C, et al. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. Hum Mol Genet 1993;3:229-235.
62. Singer MS, Shepherd GM, Greer CA. Olfactory receptors guide axons. Nature 1995;377:19-20.
63. Hughes AL, Hughes MK. Adaptive evolution in the rat olfactory receptor gene family. J Mol Evol 1993;36:249-254.
64. Prestwich GD, Du G, Laforest S. How is pheromone specificity encoded in proteins? Chem Senses 1995;20:461-469.